CAS 2810137-86-9

XOR/URAT1-IN-1

Fórmula: C₁₈H₁₃ClN₂O₃

InChI: InChI=1S/C18H13ClN2O3/c19-13-2-1-3-14(8-13)21-15-6-12(9-20-10-15)11-4-5-16(18(23)24)17(22)7-11/h1-10,21-22H,(H,23,24)

Chave InChI: KITCGABOPRSTRW-UHFFFAOYSA-N

SMILES: C1=CC(=CC(=C1)Cl)NC2=CN=CC(=C2)C3=CC(=C(C=C3)C(=O)O)O

Sinónimos:

• XOR/URAT1-IN-1

XOR/URAT1-IN-1

CAS: 2810137-86-9

Compound II15, known as XOR/URAT1-IN-1, serves as a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 μM, respectively. This compound effectively reduces uric acid levels in a mouse model of acute hyperuricemia induced by potassium oxonate and hypoxanthine.

Fórmula: C₁₈H₁₃ClN₂O₃

Cor e Forma: Solid

Peso molecular: 340.76

Ref: TM-T88230