CAS 2933935-13-6

Fórmula: C34H31F5N6O2

InChI: InChI=1S/C34H31F5N6O2/c1-2-22-25(36)5-4-18-10-21(46)11-23(26(18)22)28-27(37)29-24(13-40-28)30(44-15-20-6-8-34(16-44,43-20)31(38)39)42-32(41-29)47-17-33-7-3-9-45(33)14-19(35)12-33/h1,4-5,10-11,13,19-20,31,43,46H,3,6-9,12,14-17H2/t19-,20?,33+,34?/m1/s1

Chave InChI: VQTOJJXYQWYSGJ-RJBRWJMYSA-N

SMILES: C#CC1=C(C=CC2=CC(=CC(=C21)C3=NC=C4C(=C3F)N=C(N=C4N5CC6CCC(C5)(N6)C(F)F)OC[C@@]78CCCN7C[C@@H](C8)F)O)F

KRASG12D-IN-5

CAS: 2933935-13-6

KRASG12D-IN-5 (Compound 241) is an orally active KRAS(G12D) inhibitor with an IC50 of 11 nM. It demonstrates potent anticancer activity without significant cytotoxicity to BxPC-3 cells (wild-type), KRAS-mutant AsPC-1 cells (G12D), and MIAPaCa-2 cells (G12C), with CC50 values of 10.37, 0.76, and 0.3 μM, respectively. KRASG12D-IN-5 is applicable in cancer studies, including lung, pancreatic, and colorectal cancers.

Fórmula: C₃₄H₃₁F₅N₆O₂

Cor e Forma: Solid

Peso molecular: 650.64

Ref: TM-T211223