CAS 2933935-13-6

KRASG12D-IN-5

CAS: 2933935-13-6

KRASG12D-IN-5 (Compound 241) is an orally active KRAS(G12D) inhibitor with an IC50 of 11 nM. It demonstrates potent anticancer activity without significant cytotoxicity to BxPC-3 cells (wild-type), KRAS-mutant AsPC-1 cells (G12D), and MIAPaCa-2 cells (G12C), with CC50 values of 10.37, 0.76, and 0.3 μM, respectively. KRASG12D-IN-5 is applicable in cancer studies, including lung, pancreatic, and colorectal cancers.

Fórmula: C₃₄H₃₁F₅N₆O₂

Cor e Forma: Solid

Peso molecular: 650.64

Ref: TM-T211223