CAS 3002417-64-0

Fórmula: C57H71N15O6

InChI: InChI=1S/C57H71N15O6/c1-7-23-70-55(77)45-35-60-56(63-51(45)72(70)49-13-11-12-48(62-49)57(5,6)78)61-40-16-20-41(21-17-40)69-31-29-66(30-32-69)24-10-9-22-59-50(75)37-68-27-25-67(26-28-68)36-39-14-18-42(19-15-39)71-52(64-65-53(71)54(76)58-8-2)44-33-43(38(3)4)46(73)34-47(44)74/h7,11-21,33-35,38,73-74,78H,1,8-10,22-32,36-37H2,2-6H3,(H,58,76)(H,59,75)(H,60,61,63)

Chave InChI: VWKHGQQDVPXYOQ-UHFFFAOYSA-N

SMILES: CCNC(=O)C1=NN=C(N1C2=CC=C(C=C2)CN3CCN(CC3)CC(=O)NCCCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC=C7C(=N6)N(N(C7=O)CC=C)C8=CC=CC(=N8)C(C)(C)O)C9=CC(=C(C=C9O)O)C(C)C

HEMTAC WEE1 degrader-1

CAS: 3002417-64-0

HEMTACWEE1degrader-1 is a WEE1-targeting heterobifunctional chimeric degrader (HEMTAC) facilitated by HSP90, exhibiting an HSP90 enzyme inhibitory activity with an IC₅₀ of 16.76 nM. It enhances the ubiquitination and subsequent degradation of WEE1, effectively blocking the G2/M cell cycle transition. This compound shows anticancer properties in patient-derived xenograft (PDX) models of acute myeloid leukemia (AML). HEMTACWEE1degrader-1 is utilized in AML research.

Fórmula: C₅₇H₇₁N₁₅O₆

Cor e Forma: Solid

Peso molecular: 1062.27

Ref: TM-T207012