CAS 3030279-55-8

Fórmula: C39H46F6N8O5S

InChI: InChI=1S/C39H46F6N8O5S/c1-38(56)12-2-13-53(22-38)35-27(39(43,44)45)19-46-37(49-35)47-31-6-4-25(18-28(31)40)59(57,58)50-32-11-14-51(21-30(32)42)20-23-9-15-52(16-10-23)33-7-3-24(17-29(33)41)26-5-8-34(54)48-36(26)55/h3-4,6-7,17-19,23,26,30,32,50,56H,2,5,8-16,20-22H2,1H3,(H,46,47,49)(H,48,54,55)/t26?,30-,32+,38-/m0/s1

Chave InChI: MQWDHROLFNTJMK-PONYFJNFSA-N

SMILES: C[C@@]1(CCCN(C1)C2=NC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)S(=O)(=O)N[C@@H]4CCN(C[C@@H]4F)CC5CCN(CC5)C6=C(C=C(C=C6)C7CCC(=O)NC7=O)F)F)O

CDK2 degrader 7

CAS: 3030279-55-8

CDK2 degrader7 is an orally active CDK2 degrader with DC₅₀ values of 13 nM in MKN1 cells and 17 nM in TOV21G cells. It induces G1 phase arrest in MKN1 cells and achieves tumor suppression in the HCC1569 (CCNE1 amplified) xenograft model. CDK2 degrader7 is utilized in research on CCNE1 amplification-type cancers.

Fórmula: C₃₉H₄₆F₆N₈O₅S

Peso molecular: 852.9

Ref: TM-T212958