CAS 3050611-33-8

Fórmula: C23H25F3N2O4

InChI: InChI=1S/C23H25F3N2O4/c1-14-11-16(12-15(2)19(14)32-22(3,4)20(29)30)13-27-9-10-28(21(27)31)18-7-5-17(6-8-18)23(24,25)26/h5-8,11-12H,9-10,13H2,1-4H3,(H,29,30)

Chave InChI: SJFIYCLXFWXYJF-UHFFFAOYSA-N

SMILES: CC1=CC(=CC(=C1OC(C)(C)C(=O)O)C)CN2CCN(C2=O)C3=CC=C(C=C3)C(F)(F)F

PPARα/δ agonist 3

CAS: 3050611-33-8

PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.

Fórmula: C₂₃H₂₅F₃N₂O₄

Cor e Forma: Solid

Peso molecular: 450.451

Ref: TM-T205373