CAS 3060730-06-2

MS8790

Sinónimos:

• MS8790

MS-8709

CAS: 3060730-06-2

MS-8709

Fórmula: C₆₄H₉₅F₂N₁₁O₇S

Pureza: ≥98%

Peso molecular: 1200.57

Ref: 54-PC1034002

MS-8709

CAS: 3060730-06-2

MS-8709 is a potent and selective G9a/GLP PROTAC Degrader with a DC50(G9a) of 274 nM and a DC50(GLP) of 260 nM. It induces G9a/GLP protein degradation in a concentration-dependent and time-dependent manner via the ubiquitin-proteasome system, without affecting mRNA expression levels. MS-8709 demonstrates superior cell growth inhibition compared to the parent compound UNC0642 in prostate cancer, leukemia, and lung cancer cell models, and exhibits mouse pharmacokinetic characteristics suitable for in vivo efficacy studies.

Fórmula: C₆₄H₉₅F₂N₁₁O₇S

Pureza: 99.98%

Cor e Forma: White Solid

Peso molecular: 1200.57

Ref: TM-T202458