CAS 3064086-31-0

Fórmula: C38H38F2N10O8

InChI: InChI=1S/C38H38F2N10O8/c1-20(2)49-19-43-48-34(49)26-7-4-8-29(44-26)46-35(54)22-17-27(24(40)18-23(22)39)45-31(52)12-11-30(51)42-14-16-58-15-13-41-25-6-3-5-21-33(25)38(57)50(37(21)56)28-9-10-32(53)47-36(28)55/h3-8,17-20,28,41H,9-16H2,1-2H3,(H,42,51)(H,45,52)(H,44,46,54)(H,47,53,55)

Chave InChI: NYIDUKMXSLPHBJ-UHFFFAOYSA-N

SMILES: CC(C)N1C=NN=C1C2=NC(=CC=C2)NC(=O)C3=CC(=C(C=C3F)F)NC(=O)CCC(=O)NCCOCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O

dASK1

CAS: 3064086-31-0

dASK1 is a selective CRBN-based PROTAC degrader targeting apoptosis signal-regulating kinase 1 (ASK1). It forms a stable ternary complex with ASK1, facilitating its rapid and sustained degradation via the ubiquitin-proteasome pathway. dASK1 exhibits strong ASK1 degradation capabilities and is applicable for hepatitis research.

Fórmula: C₃₈H₃₈F₂N₁₀O₈

Cor e Forma: Solid

Peso molecular: 800.77

Ref: TM-T211263