CAS 3075162-42-1

Fórmula: C24H23N5O4S2

InChI: InChI=1S/C24H23N5O4S2/c30-34(31,22-5-1-3-17-4-2-12-25-23(17)22)27-19-8-6-18(7-9-19)24-26-13-14-29(24)20-15-28(16-20)35(32,33)21-10-11-21/h1-9,12-14,20-21,27H,10-11,15-16H2

Chave InChI: NMBABIRNQFJWIE-UHFFFAOYSA-N

SMILES: C1CC1S(=O)(=O)N2CC(C2)N3C=CN=C3C4=CC=C(C=C4)NS(=O)(=O)C5=CC=CC6=C5N=CC=C6

PKM2 agonist-1

CAS: 3075162-42-1

PKM2 agonist-1 (Compound D16) is a potent allosteric activator of PKM2, with an AC50 value of 77 nM. It inhibits angiotensin II-induced smooth muscle cell phenotypic transformation, effectively preventing aortic dissection and reducing mortality.

Fórmula: C₂₄H₂₃N₅O₄S₂

Peso molecular: 509.6

Ref: TM-T214850