CAS 3091068-95-7

Fórmula: C19H18N6S

InChI: InChI=1S/C19H18N6S/c1-25-7-5-14-16(10-25)26-19-17(14)18(21-11-22-19)24-23-9-12-2-3-15-13(8-12)4-6-20-15/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,21,22,24)/b23-9+

Chave InChI: RIKFCCLHMJMGRI-NUGSKGIGSA-N

SMILES: CN1CCC2=C(C1)SC3=NC=NC(=C23)N/N=C/C4=CC5=C(C=C4)NC=C5

Arf1-GEFs-IN-1

CAS: 3091068-95-7

Arf1-GEFs-IN-1 is a potent and orally active inhibitor of ADP-ribosylation factor 1-guanine nucleotide exchange factors (Arf1-GEFs), exhibiting an IC₅₀ value of 40 μM in CT26 cells. Primarily, Arf1-GEFs-IN-1 induces tumor regression by triggering anti-tumor immune responses rather than direct cytotoxicity. It effectively enhances CCL5 expression and demonstrates excellent in vivo efficacy. Arf1-GEFs-IN-1 is applicable in colon cancer research.

Fórmula: C₁₉H₁₈N₆S

Peso molecular: 362.45

Ref: TM-T212402