CAS 3094-09-5

Doxifluridina

Descrição:

Doxifluridina, com o número CAS 3094-09-5, é um análogo de pirimidina fluorada usado principalmente na terapia do câncer. Está estruturalmente relacionado com o nucleosídeo timidina e funciona como um antimetabolito, inibindo a síntese de DNA ao interferir com a ação da timidilato sintase. Este mecanismo o torna particularmente eficaz contra células cancerosas que se dividem rapidamente. Doxifluridina é tipicamente administrado em sua forma de pró-fármaco, que é convertida em seu metabolito ativo dentro do corpo. O composto apresenta um perfil de toxicidade relativamente baixo em comparação com outros agentes quimioterapêuticos, tornando-se uma opção valiosa em terapias combinadas para várias malignidades. Em termos de propriedades físicas, Doxifluridina é um pó cristalino branco a off-white, solúvel em água, e tem um peso molecular moderado. Sua farmacocinética envolve processos de absorção, distribuição, metabolismo e excreção que são cruciais para sua eficácia terapêutica. No geral, Doxifluridina representa uma ferramenta importante no arsenal da farmacoterapia oncológica, particularmente para cânceres gastrointestinais.

Fórmula: C₉H₁₁FN₂O₅

InChI: InChI=1/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6?,8?/m1/s1

Chave InChI: InChIKey=ZWAOHEXOSAUJHY-ZIYNGMLESA-N

SMILES: O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)NC(=O)C(F)=C2

Sinónimos:

• (2Xi)-5'-Deoxy-5-Fluorouridine
• 5'-Deoxy-5-fluorouridine
• 5'-Dfur
• 5-Fluoro-5'-deoxyuridine
• 5-Fluorodesoxyuridine
• 5′-dFUrd
• Flutron
• Fulturon
• Furtulon
• Ro 21-9738
• Uridine, 5′-deoxy-5-fluoro-
• Doxifluridine
• 5Urd, 5-Fluoro-5deoxyuridine
• Doxifluridine (furtulon)
• 5'-Deoxy-fluorouridine(DFUR)/Doxifluridine
• (+)-5-FLUORO-5'-DEOXYURIDINE 97%
• 5'-DEOXYFLUOROURIDINE
• 5-FLURO-5’-DEOXYURIDINE
• DOXIFLUIRDINE
• 5Deoxy-5-fluorouridine, 5DFUR, 5dFUrd, Ro-21-9738
• Doxifluidine
• DOXIFLURIDINE(SUBJECTTOPATENTFREE)

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Pureza: >98.0%(HPLC)(T)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 246.19

Ref: 3B-D3579

CAPECITABINE IMPURITY B CRS

CAS: 3094-09-5

CAPECITABINE IMPURITY B CRS

Fórmula: C₁₅H₂₂FN₃O₆

Peso molecular: 359.3501

Ref: 41-Y0001644

Capecitabine Related Compound B

CAS: 3094-09-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₉H₁₁FN₂O₅

Cor e Forma: White Powder

Peso molecular: 246.0652

Ref: 45-1090728

Doxifluridine

CAS: 3094-09-5

Doxifluridine

Fórmula: C₉H₁₁FN₂O₅

Pureza: ≥98%

Peso molecular: 246.19

Ref: 54-BUP19641

(+)-5-Fluoro-5'-deoxyuridine

CAS: 3094-09-5

(+)-5-Fluoro-5'-deoxyuridine

Fórmula: C₉H₁₁FN₂O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 246.19244

Ref: 54-PC5775

Doxifluridine

CAS: 3094-09-5

Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.

Fórmula: C₉H₁₁FN₂O₅

Pureza: 99.47% - 99.86%

Cor e Forma: Solid

Peso molecular: 246.1924

Ref: TM-T1600

Capecitabine EP Impurity B-13C5 (Capecitabine USP Related Compound B-13C5, 5'-DFUR-13C5, Doxifluridine-13C5)

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Peso molecular: 251.22

Ref: 4Z-C-355

Capecitabine EP Impurity B (Capecitabine USP Related Compound B, 5'-DFUR, Doxifluridine)

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Cor e Forma: White To Off-White Solid

Peso molecular: 246.19

Ref: 4Z-C-354

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 246.1924

Ref: IN-DA0031Q7

1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione (5'-Deoxy-5-fluorouridine)

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Cor e Forma: Neat

Peso molecular: 246.19

Ref: 86-MM0992.06

5’-Deoxyfluorouridine-13C,15N2

Produto Controlado

CAS: 3094-09-5

Applications 5’-Deoxyfluorouridine-13C,15N2 is a compound useful in organic synthesis.

Fórmula: C₈CH₁₁FN₂O₅

Cor e Forma: Neat

Peso molecular: 249.17

Ref: TR-D235727

Doxifluridine

Produto Controlado

CAS: 3094-09-5

Impurity USP Capecitabine Related Compound B / Capecitabine EP Impurity B
Applications A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity.
References De Cesare, M., et al.: Cancer Res., 49, 5969 (1994), Di Bartolomeo, M., et al.: Tumori, 81, 147 (1995)

Fórmula: C₉H₁₁FN₂O₅

Cor e Forma: Neat

Peso molecular: 246.19

Ref: TR-D556750

5’-Deoxy-5-fluorouridine

Produto Controlado

CAS: 3094-09-5

Impurity USP Capecitabine Related Compound B
Applications 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
References Ingle, J., et al.: Cancer, 67, 886 (1991); Harvey, J., et al.: J. Clin. Oncol., 17, 1474 (1999); Asai-Sato, M., et al.: Int. J. Cancer, 115, 539 (2005); Rastelli, F., et al.: Tumori, 94, 370 (2008);

Fórmula: C₉H₁₁FN₂O₅

Cor e Forma: Neat

Peso molecular: 246.19

Ref: TR-D235725

5-Fluoro-5''-deoxyuridine

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Peso molecular: 246.19

Ref: 7W-GP7931

Doxifluridine

CAS: 3094-09-5

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione

Fórmula: C₉H₁₁FN₂O₅

Pureza: 98%

Peso molecular: 246.19

Ref: IN-DG104048

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

5'-Deoxy-5-fluorouridine (5FU) is a nucleoside that is used in the treatment of cancer. It is an antimetabolite that inhibits the synthesis of DNA, RNA, and proteins by reversibly inhibiting ribonucleotide reductase. 5FU also inhibits epidermal growth factor receptor (EGFR), which leads to apoptosis in cancerous cells. The concentration–time curve for 5FU has been determined using tissue culture and hl-60 cells as biological samples. This drug has been shown to be effective against metastatic colorectal cancer when administered with other chemotherapeutic drugs.

Fórmula: C₉H₁₁FN₂O₅

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 246.2 g/mol

Ref: 3D-ND02968

Capecitabine EP Impurity B

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Peso molecular: 246.19

Ref: ST-EA-CP-C52002

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

Fórmula: C₉H₁₁FN₂O₅

Peso molecular: 246.19

Ref: BE-MU-8158

Doxifluridine

CAS: 3094-09-5

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 246.19

Ref: 10-F787567

Doxifluridine (Standard)

CAS: 3094-09-5

Doxifluridine (Standard) is a reference standard for research and analysis in studies involving Doxifluridine. Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.

Fórmula: C₉H₁₁FN₂O₅

Peso molecular: 246.1924

Ref: TM-TMSM-3642