CAS 3101950-55-1

Fórmula: C31H34Cl2N6O4

InChI: InChI=1S/C31H34Cl2N6O4/c1-34-29(41)25(12-18-16-35-23-7-3-2-6-21(18)23)38-30(42)27-8-4-5-11-39(27)31(43)26(37-28(40)15-32)13-19-17-36-24-14-20(33)9-10-22(19)24/h2-3,6-7,9-10,14,16-17,25-27,35-36H,4-5,8,11-13,15H2,1H3,(H,34,41)(H,37,40)(H,38,42)/t25-,26-,27-/m0/s1

Chave InChI: QGCVYMAIWRYCCM-QKDODKLFSA-N

SMILES: CNC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H]3CCCCN3C(=O)[C@H](CC4=CNC5=C4C=CC(=C5)Cl)NC(=O)CCl

PIN1 degrader-3

CAS: 3101950-55-1

PIN1degrader-3 is a degrader of Pin1 (peptidyl-prolyl isomerase protein) with an IC50 of 4.65 nM. It covalently binds to Pin1 and destabilizes it in vitro, leading to its degradation within cells. PIN1degrader-3 can be utilized in pancreatic cancer research.

Fórmula: C₃₁H₃₄Cl₂N₆O₄

Peso molecular: 625.55

Ref: TM-T214076