CAS 3116731-08-6

Fórmula: C18H13Cl2N5O2S

InChI: InChI=1S/C18H13Cl2N5O2S/c19-13-8-14(20)10-15(9-13)22-18-23-17(21)25(24-18)28(26,27)16-6-5-11-3-1-2-4-12(11)7-16/h1-10H,(H3,21,22,23,24)

Chave InChI: ZYZAGBOMZOKYHI-UHFFFAOYSA-N

SMILES: C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)N3C(=NC(=N3)NC4=CC(=CC(=C4)Cl)Cl)N

GSK-3β inhibitor 23

CAS: 3116731-08-6

GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.

Fórmula: C₁₈H₁₃Cl₂N₅O₂S

Cor e Forma: Solid

Peso molecular: 434.299

Ref: TM-T204398