CAS 31282-04-9

Higromicina B

Descrição:

Higromicina B é um antibiótico aminoglicosídeo produzido pela bactéria *Micromonospora hygroscopicus*. É conhecido principalmente por sua capacidade de inibir a síntese de proteínas em bactérias e algumas células eucarióticas, tornando-se uma ferramenta valiosa na biologia molecular para selecionar organismos geneticamente modificados. Higromicina B é eficaz contra um amplo espectro de microrganismos, incluindo certas bactérias Gram-positivas e Gram-negativas, bem como fungos. Seu mecanismo de ação envolve a ligação ao RNA ribossômico, interrompendo o processo de tradução. O composto é tipicamente utilizado em ambientes de laboratório para a seleção de células que foram transformadas com genes de resistência à higromicina. Higromicina B é solúvel em água e apresenta estabilidade sob várias condições de pH, embora seja sensível à luz e deva ser armazenado em um ambiente escuro. Precauções de segurança são necessárias ao manusear este composto, pois pode ser tóxico para humanos e outros organismos em altas concentrações. No geral, Higromicina B é um reagente crucial na engenharia genética e na pesquisa em biologia celular.

Fórmula: C₂₀H₃₇N₃O₁₃

InChI: InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20?/m1/s1

Chave InChI: InChIKey=GRRNUXAQVGOGFE-HUCHGKBZSA-N

SMILES: O[C@H]1C2(O[C@]3([C@@](O2)([C@@H](O)[C@@H](CO)O[C@H]3O[C@H]4[C@H](O)[C@@H](NC)C[C@@H](N)[C@@H]4O)[H])[H])O[C@]([C@H](CO)N)([C@H](O)[C@@H]1O)[H]

Sinónimos:

• (3'R,3aS,4S,4'R,5'R,6R,6'R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)octahydro-4H-spiro[1,3-dioxolo[4,5-c]pyran-2,2'-pyran]-3',4',5',7-tetrol (non-preferred name)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-<smallcap>L</smallcap>-glycero-<smallcap>D</smallcap>-galacto-heptopyranosylidene-(1→2-3)-O-β-<smallcap>D</span>-talopyranosyl-(1→5)-2-deoxy-N³-methyl-
• Antihelmycin
• Hygromix 2.4
• Hygromix-8
• Hygromycin B
• Hygromycin B - Solution
• Hygromycin B Streptomyces hygroscopicus
• Hygromycin B solution Streptomyces hygroscopicus
• Hygrovetin
• Hygrovetine
• O-6-Amino-6-deoxy-<span class="text-smallcaps">L</smallcap>-glycero-<smallcap>D</smallcap>-galacto-heptopyranosylidene-(1→2-3)-O-β-<smallcap>D</smallcap>-talopyranosyl-(1→5)-2-deoxy-N³-methyl-<smallcap>D</span>-streptamine
• hygromycin B aqueous solution
• hygromycin B from streptomyces*hygroscopicus
• hygromycin B plant cell culture tested
• D-Streptamine, O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1→2-3)-O-β-D-talopyranosyl-(1→5)-2-deoxy-N3-methyl-

Hygromycin B

CAS: 31282-04-9

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: >90.0%(HPLC)(qNMR)

Cor e Forma: White to Light yellow to Light orange powder to crystal

Peso molecular: 527.52

Ref: 3B-H1509

Hygromycin B

CAS: 31282-04-9

Hygromycin B, 31282-04-9, is an aminoglycoside antibiotic which exhibits activity against eukaryotic and prokaryotic cells through inhibition of protein synthesis. Learn more.

Fórmula: C₂₀H₃₇N₃O₁₃

Cor e Forma: Cream to plale brown, Powder

Peso molecular: 527.52

Ref: 02-J60681

Hygromycin B, 50 mg/ml in distilled water, sterile-filtered

CAS: 31282-04-9

Hygromycin B, 50mg/mL in distilled water, sterile-filtered

Fórmula: C₂₀H₃₇N₃O₁₃

Cor e Forma: Liquid, Pale yellow to brown

Peso molecular: 527.52

Ref: 02-J67371

Hygromycin B, PBS solution, 1 pack = 20ml

CAS: 31282-04-9

Hygromycin B, PBS solution, 1 pack = 20ml

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: ≥95%

Cor e Forma: Liquid

Peso molecular: 527.52008

Ref: 54-BIH0125

Hygromycin B, powder

CAS: 31282-04-9

Hygromycin B, powder

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: By hplc: 99.4% (Typical Value in Batch COA)

Cor e Forma: Beige Solid-Powder

Peso molecular: 527.52008

Ref: 54-BIH4302

Hygromycin B

CAS: 31282-04-9

Hygromycin B disrupts protein synthesis in 70S ribosomes, used as an anthelmintic in swine.

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: 98% - 99.95%

Cor e Forma: White Solid

Peso molecular: 527.52

Ref: TM-T1022

Hygromycin B

CAS: 31282-04-9

Hygromycin B

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: 99.5%

Cor e Forma: Solid

Peso molecular: 527.52

Ref: 54-BUP17695

Hygromycin B

CAS: 31282-04-9

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: ≥ 90.0%

Cor e Forma: White to beige powder

Peso molecular: 527.53

Ref: 7W-GA7834

Hygromycin B

Produto Controlado

CAS: 31282-04-9

Fórmula: C₂₀H₃₇N₃O₁₃

Cor e Forma: Neat

Peso molecular: 527.52

Ref: 04-C14260000

Hygromycin B (Standard)

CAS: 31282-04-9

Hygromycin B (Standard) is the standard substance of Hygromycin B, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis in both prokaryotic and eukaryotic cells by interfering with translocation and causing mistranslation by the 70S ribosome. It is commonly used for the selection of cells transfected with the hph or hyg resistance gene.

Fórmula: C₂₀H₃₇N₃O₁₃

Cor e Forma: Solid

Peso molecular: 527.52

Ref: TM-TMSM-1343

Hygromycin B

Produto Controlado

CAS: 31282-04-9

Applications Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cha, T.S., et al.: World. J. Microbiol. Biotechnol., 28, 1771 (2012); Herrero, L., et al.: Biochem., 52, 171 (2013);

Fórmula: C₂₀H₃₇N₃O₁₃

Cor e Forma: Neat

Peso molecular: 527.52

Ref: TR-H997600

Hygromycin B Deuterated (d4 major)

Produto Controlado

CAS: 31282-04-9

Fórmula: C₂₀H₃₃D₄N₃O₁₃

Cor e Forma: Neat

Peso molecular: 531.54

Ref: TR-H997604

Hygromycin B

CAS: 31282-04-9

Fórmula: C₂₀H₃₇N₃O₁₃

Peso molecular: 527.52

Ref: 4Z-H-062002

Hygromycin B - min 90%

CAS: 31282-04-9

Inhibitor of protein synthesis; aminoglycoside

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: Min. 90 Area-%

Cor e Forma: Powder

Peso molecular: 527.52 g/mol

Ref: 3D-AH159881

Hygromycin B

CAS: 31282-04-9

Hygromycin B binds near the A site of 16S rRNA and induces errors in the code by inhibition of translocation of peptydil-tRNA, however to a lesser extent compared to other aminoglycosides. Hygromycin B is efficient against bacteria, fungi and other eukaryotic cells, but more often used for the selection of eukaryotic cells including yeasts, such as, P. pastoris and S. cerevisiae, and mammalian cell lines, such as, CHO.

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 527.52 g/mol

Ref: 3D-AH11348

Hygromycin B

CAS: 31282-04-9

Fórmula: C₂₀H₃₇N₃O₁₃

Cor e Forma: Amorphous solid or tan powder. (NTP, 1992)

Peso molecular: 527.5

Ref: BE-RMCH082002

Hygromycin B

CAS: 31282-04-9

Fórmula: C₂₀H₃₇N₃O₁₃

Cor e Forma: Amorphous solid or tan powder. (NTP, 1992)

Peso molecular: 527.5

Ref: BE-BePure-23468

Hygromycin B

CAS: 31282-04-9

(3aS,3'R,4S,4'S,5'R,6R,6'R,7S,7aS)-4-(((1R,2S,3R,5S,6R)-3-Amino-2,6-dihydroxy-5-(methylamino)cyclohexyl)oxy)-6'-((S)-1-amino-2-hydroxyethyl)-6-(hydroxymethyl)octahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-pyran]-3',4',5',7-tetraol

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: ≥950U/mg

Peso molecular: 527.52

Ref: IN-DG134243

Hygromycin B

CAS: 31282-04-9

Fórmula: C₂₀H₃₇N₃O₁₃

Peso molecular: 527.52

Ref: ST-EA-CP-H48000

Hygromycin B (HGR), 90%

CAS: 31282-04-9

Fórmula: C₂₀H₃₇N₃O₁₃

Pureza: min. 90%

Cor e Forma: White to off - white, Powder

Peso molecular: 527.52

Ref: SR-67317