CAS 31618-90-3

dietil (tosiloxi)metilfosfonato

Descrição:

dietil (tosiloxi)metilfosfonato, com o número CAS 31618-90-3, é um composto organofosforado caracterizado por sua estrutura de fosfonato, que inclui um átomo de fósforo ligado a um átomo de oxigênio e um grupo alquilo. Este composto apresenta dois grupos etila e um grupo tosila, que aumenta sua reatividade e solubilidade em solventes orgânicos. Normalmente é um líquido incolor a amarelo pálido e é conhecido por suas aplicações na síntese orgânica, particularmente como um reagente na preparação de vários fosfonatos e fosfonamidatos. A presença do grupo tosila contribui para sua natureza eletrofílica, tornando-o útil em reações de substituição nucleofílica. Além disso, dietil (tosiloxi)metilfosfonato pode apresentar toxicidade moderada, comum entre compostos organofosforados, exigindo manuseio cuidadoso e medidas de segurança adequadas durante o uso. Suas propriedades químicas, incluindo estabilidade e reatividade, fazem dele um intermediário valioso na síntese de produtos farmacêuticos e agroquímicos.

Fórmula: C₁₂H₁₉O₆PS

InChI: InChI=1/C12H19O6PS/c1-4-16-19(13,17-5-2)10-18-20(14,15)12-8-6-11(3)7-9-12/h6-9H,4-5,10H2,1-3H3

Chave InChI: InChIKey=UOEFFQWLRUBDME-UHFFFAOYSA-N

SMILES: S(OCP(OCC)(OCC)=O)(=O)(=O)C1=CC=C(C)C=C1

Sinónimos:

• (Diethoxyphosphoryl)Methyl 4-Methylbenzenesulfonate
• 4-Methylbenzenesulfonic acid (diethoxyphosphoryl)methyl ester
• Desmp
• Detp
• Diethoxyphosphorylmethyl tosylate
• Diethyl P-Toluenesulfonyl Oxymethyl Phosphonate
• Diethyl P-Tosyloxymethylphosphonate
• Diethyl P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]phosphonate
• Diethyl [[(P-Toluenesulfonyl)Oxy]Methyl]Phosphonate
• Diethyl [[[(4-Tolyl)Sulfonyl]Oxy]Methyl]Phosphonate
• Diethyl p-toluene sulfonyl oxymethyl phosphonate
• Diethyl p-toluene sulfonyloxy methyl phosphonate
• Diethyl  p-toluenesulfonyloxymethylphosphonate
• PMPA monohydrate
• Phosphonic acid, (hydroxymethyl)-, diethyl ester, p-toluenesulfonate
• Phosphonic acid, P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester
• Phosphonic acid, [[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester
• Tosyloxymethyl Diethyl Phosphonate
• [[[(4-Tolyl)Sulfonyl]Oxy]Methyl]Phosphonic Acid Diethyl Ester
• Diethyl(tosyloxy)methylphosphonate
• Diethyl p-toluene sulfonyloxy methyl phosphonate(DESMP)
• PHOSPHONIC ACID, [[[(4-METHYLPHENYL)SULFONYL]OXY]METHYL]-, DIETHYL ESTER (9CI)
• Diethylp-toluenesulfonyloxymenthylphosphonate
• p-toluenesulfonyloxy methylphosphonate
• DIETHYL 4-TOLUENESULFONYLOXYMETHYLPHOSPHONATE
• DETHYL (TOSYLOXY) METHYLPHOSPHONATE
• TOLUENE-4-SULFONIC ACID DIETHOXY-PHOSPHORYLMETHYL ESTER
• DIETHYL(TOSYLOXYMETHYL)PHOSPHONATE
• Diethyl(Tosyloxy)methylphosphonte
• 4-METHYLPHENYL]SULFONYL]OXY]METHYLPHOSPHONICACIDDIETHYLESTER

Diethyl (p-Toluenesulfonyloxymethyl)phosphonate

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Pureza: >97.0%(GC)

Cor e Forma: Colorless to Light yellow clear liquid

Peso molecular: 322.31

Ref: 3B-D4968

(Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Pureza: 98%

Cor e Forma: Liquid

Peso molecular: 322.3144

Ref: IN-DA0034QG

Diethyl(tosyloxy)methylphosphonate

CAS: 31618-90-3

Diethyl(tosyloxy)methylphosphonate

Fórmula: C₁₂H₁₉O₆PS

Pureza: 98%

Cor e Forma: Solid-Low Melt

Peso molecular: 322.31442

Ref: 54-OR53035

Tenofovir Impurity 36

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Peso molecular: 322.31

Ref: 4Z-T-0280

Tenofovir Impurity 66

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Peso molecular: 322.31

Ref: ST-EA-CP-T5013

Diethyl p-tosyloxymethylphosphonate

CAS: 31618-90-3

Diethyl p-tosyloxymethylphosphonate is an organic compound that is used in the synthesis of tenofovir. It is a salt of diethyl phosphate and p-toluenesulfonyl chloride, which reacts with magnesium chloride to form diethyl p-tosyloxymethylphosphonate. Diethyl p-tosyloxymethylphosphonate is also used as a reagent for the acylation reaction of phosphites and chlorides. This reaction has been shown to be useful in the synthesis of many organic compounds, including drugs such as methyldopa and acetazolamide. Diethyl p-tosyloxymethylphosphonate has also been shown to have anti-cancer properties. The mechanism of this effect is not well understood, but it may be due to inhibition of DNA replication or the induction of apoptosis by reactive oxygen species (ROS).

Fórmula: C₁₂H₁₉O₆PS

Pureza: Min. 95%

Cor e Forma: Colorless Clear Liquid

Peso molecular: 322.32 g/mol

Ref: 3D-FD10108

(Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Pureza: 97%

Cor e Forma: White powder

Peso molecular: 322.31

Ref: 10-F213393

Diethyl p-Toluenesulfonyloxymethylphosphonate

Produto Controlado

CAS: 31618-90-3

Applications Diethyl p-Toluenesulfonyloxymethylphosphonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

Fórmula: C₁₂H₁₉O₆PS

Cor e Forma: Neat

Peso molecular: 322.31

Ref: TR-D445260