CAS 366789-02-8

Rivaroxabana

Descrição:

Rivaroxabana é um medicamento anticoagulante oral utilizado principalmente para a prevenção e tratamento de distúrbios tromboembólicos, como trombose venosa profunda e embolia pulmonar. Funciona como um inibidor direto do fator Xa, que interrompe a cascata de coagulação e reduz a formação de coágulos sanguíneos. Rivaroxabana é caracterizado por sua alta biodisponibilidade e farmacocinética previsível, permitindo dosagem fixa sem a necessidade de monitoramento rotineiro dos parâmetros de coagulação. A substância é tipicamente administrada em forma de comprimido e é absorvida rapidamente, com concentrações plasmáticas máximas ocorrendo dentro de algumas horas após a ingestão. É metabolizada principalmente no fígado através das enzimas do citocromo P450 e é excretada por vias renais e fecais. Efeitos colaterais comuns podem incluir complicações hemorrágicas, o que exige cautela em pacientes com certos fatores de risco. O perfil de eficácia e segurança de Rivaroxabana fez dele uma opção amplamente utilizada na terapia anticoagulante, embora seja contraindicado em pacientes com hemorragia ativa ou comprometimento renal severo.

Fórmula: C₁₉H₁₈ClN₃O₅S

InChI: InChI=1/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1

Chave InChI: InChIKey=KGFYHTZWPPHNLQ-AWEZNQCLSA-N

SMILES: O=C1N(C[C@H](CNC(=O)C=2SC(Cl)=CC2)O1)C3=CC=C(C=C3)N4C(=O)COCC4

Sinónimos:

• (S)-Rivaroxaban
• 2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-
• 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
• 5-Chloro-N-([(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl]-methyl)-2-thiophenecarboxamide
• 5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
• 5-Chloro-N-[[(S)-3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-thiophene-2-carboxamide
• 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl]thiophene-2-carboxamide
• Bay 59-7939
• Rivaroxaban intermediates
• Rivaroxban
• Xarelto
• Rivaroxaban
• (S)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
• Rivaroxaban API
• Rivarobaxan
• Rivaroxaban(Xarelto)
• (S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carboxami
• Rivaroxaba

Rivaroxaban

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 435.88

Ref: 3B-R0269

RIVAROXABAN CRS

CAS: 366789-02-8

RIVAROXABAN CRS

Ref: 41-Y0002187

Rivaroxaban

CAS: 366789-02-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₉H₁₈ClN₃O₅S

Cor e Forma: White Powder

Peso molecular: 435.06557

Ref: 45-1604530

5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 435.8813

Ref: IN-DA0035KL

Rivaroxaban

CAS: 366789-02-8

Rivaroxaban

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: 99.50%

Cor e Forma: Solid

Peso molecular: 435.88

Ref: 54-OR1028886

Rivaroxaban

CAS: 366789-02-8

Rivaroxaban (BAY 59-7939) is an oral, direct factor Xa inhibitor with anticoagulant properties, interfering with thrombin formation.

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: 99.93% - >99.99%

Cor e Forma: White Solid

Peso molecular: 435.88

Ref: TM-T1184

Rivaroxaban

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Cor e Forma: White To Off-White Solid

Peso molecular: 435.88

Ref: 4Z-R-291

Rivaroxaban

CAS: 366789-02-8

Rivaroxaban

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: ≥98%

Peso molecular: 435.88

Ref: 54-BUP12991

Rivaroxaban

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: ≥ 98.0% (dried basis)

Cor e Forma: White to off-white powder

Peso molecular: 435.88

Ref: 7W-GP9456

Rivaroxaban

Produto Controlado

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Cor e Forma: Neat

Peso molecular: 435.88

Ref: 86-MM3629.00

Rivaroxaban (Standard)

CAS: 366789-02-8

Rivaroxaban (Standard) is a reference standard for research and analysis in studies involving Rivaroxaban. Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels.

Fórmula: C₁₉H₁₈ClN₃O₅S

Peso molecular: 435.88

Ref: TM-TMSM-3472

Rivaroxaban

CAS: 366789-02-8

Cor e Forma: Neat

Ref: 04-C16815330

Rivaroxaban

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Peso molecular: 435.88

Ref: ST-EA-CP-R17000

Rivaroxaban

CAS: 366789-02-8

Applications A novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.
References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),

Fórmula: C₁₉H₁₈ClN₃O₅S

Cor e Forma: Neat

Peso molecular: 435.88

Ref: TR-R538000

Rivaroxaban

CAS: 366789-02-8

Rivaroxaban is a natural drug that is a direct factor Xa inhibitor. It has been shown to be an effective therapy for the treatment of atrial fibrillation, deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting the enzyme, thrombin, which is responsible for the formation of blood clots. Rivaroxaban also has an effect on the coagulation system by decreasing the levels of fibrinogen and increases in antithrombin III. This drug does not have any specific antidote, but it can be reversed with heparin. Pharmacodynamics and drug interactions have been studied extensively in preclinical models, demonstrated by the concentration–time curves.

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: Min. 98 Area-%

Cor e Forma: White Off-White Powder

Peso molecular: 435.88 g/mol

Ref: 3D-FR27742

Rivaroxaban - Bio-X ™

CAS: 366789-02-8

Rivaroxaban is a natural drug that is a direct factor Xa inhibitor. It has been shown to be an effective therapy for the treatment of atrial fibrillation, deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting the enzyme, thrombin, which is responsible for the formation of blood clots. Rivaroxaban also has an effect on the coagulation system by decreasing the levels of fibrinogen and increases in antithrombin III. This drug does not have any specific antidote, but it can be reversed with heparin. Pharmacodynamics and drug interactions have been studied extensively in preclinical models, demonstrated by the concentration–time curves.

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 435.88 g/mol

Ref: 3D-BR164355

Rivaroxaban

CAS: 366789-02-8

Ref: BE-RMCR095000

Rivaroxaban

CAS: 366789-02-8

(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: 98%

Peso molecular: 435.88

Ref: IN-DG157897