CAS 42553-65-1

Crocin

Descrição:

Crocin é um pigmento carotenoide derivado principalmente da planta de açafrão, Crocus sativus. É conhecido por sua vibrante cor amarelo-alaranjada e é responsável pela tonalidade característica do açafrão. Quimicamente, Crocin é um derivado glicosilado da crocetina, consistindo em uma estrutura de ácido dicarboxílico com múltiplos grupos de açúcar anexados, o que melhora sua solubilidade em água. Crocin exibe várias atividades biológicas, incluindo efeitos antioxidantes, anti-inflamatórios e potenciais efeitos neuroprotetores, tornando-o de interesse tanto nas indústrias alimentícia quanto farmacêutica. É frequentemente estudado por suas potenciais aplicações terapêuticas, particularmente no contexto de doenças neurodegenerativas e distúrbios de humor. Além disso, Crocin é reconhecido por seu papel como corante natural em produtos alimentícios, proporcionando uma alternativa segura aos corantes sintéticos. Sua estabilidade e biodisponibilidade são fatores importantes em sua aplicação, e a pesquisa em andamento continua a explorar sua gama completa de benefícios e usos para a saúde.

Fórmula: C₄₄H₆₄O₂₄

InChI: InChI=1S/C44H64O24/c1-19(11-7-13-21(3)39(59)67-43-37(57)33(53)29(49)25(65-43)17-61-41-35(55)31(51)27(47)23(15-45)63-41)9-5-6-10-20(2)12-8-14-22(4)40(60)68-44-38(58)34(54)30(50)26(66-44)18-62-42-36(56)32(52)28(48)24(16-46)64-42/h5-14,23-38,41-58H,15-18H2,1-4H3/b6-5+,11-7+,12-8+,19-9+,20-10+,21-13+,22-14+/t23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33+,34+,35-,36-,37-,38-,41-,42-,43+,44+/m1/s1

Chave InChI: InChIKey=SEBIKDIMAPSUBY-RTJKDTQDSA-N

SMILES: C(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2O[C@@H](OC(/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)\C)\C)/C)/C)=O)[C@H](O)[C@@H](O)[C@@H]2O

Sinónimos:

• 6-O-β-D-glucopyranosyl-1-O-[(2E,4E,6E,8E,10Z,12E,14Z)-16-{[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]methyl}-2,6,11,15-tetramethylheptadeca-2,4,6,8,10,12,14,16-octaenoyl]-β-D-glucopyranose
• 8,8′-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-β-<smallcap>D</span>-glucopyranosyl) ester
• Crocetin bis(gentiobiosyl) ester
• Crocetin di(β-<span class="text-smallcaps">D</span>-gentiobiosyl) ester
• Crocetin di-β-gentiobiosyl ester
• Crocetin digentiobioside
• Crocin
• Crocin (gardenia fruit
• Crocin 1
• Crocin 4
• Crocin A
• Kiriyasu Oil Yellow GY
• Saffron
• Saffron (Natural)
• Trans-crocin-1
• all-trans-Crocetin di-β-<span class="text-smallcaps">D</span>-gentiobiosyl ester
• bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate (non-preferred name)
• trans-Crocetin di(β-<span class="text-smallcaps">D</span>-gentiobiosyl) ester
• α-Crocin
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranose, 6-O-β-<smallcap>D</span>-glucopyranosyl-, 1,1′-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]
• 8,8′-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester

Crocin (Gardenia Fruits Extract)

CAS: 42553-65-1

Fórmula: C₄₄H₆₄O₂₄

Pureza: multi component mixture(HPLC)

Cor e Forma: Light yellow to Brown powder to crystal

Peso molecular: 976.97

Ref: 3B-C1527

Crocin

CAS: 42553-65-1

Crocin

Fórmula: C₄₄H₆₄O₂₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 976.97

Ref: 54-OR1026433

Crocin

CAS: 42553-65-1

Crocin: a water-soluble carotenoid in saffron, used for flavoring, coloring, and in Chinese medicine; inhibits TNF-alpha-induced apoptosis in cells.

Fórmula: C₄₄H₆₄O₂₄

Pureza: 98.13% - 99.74%

Cor e Forma: Red Solid

Peso molecular: 976.9646

Ref: TM-T2823

Crocin

CAS: 42553-65-1

Crocin

Fórmula: C₄₄H₆₄O₂₄

Pureza: 99.5%

Cor e Forma: Solid

Peso molecular: 976.96

Ref: 54-BUP00203

Crocin I, 98%

CAS: 42553-65-1

Fórmula: C₄₄H₆₄O₂₄

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: Orange to dark red powder

Peso molecular: 976.97

Ref: 7W-GY1779

Crocin (Standard)

CAS: 42553-65-1

Crocin (Standard) is the standard substance of Crocin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer. Crocin suppresses tumor necrosis factor (TNF)alpha-induced apoptosis of pheochromocytoma (PC12) cells by modulating mRNA expressions of Bcl-2 family proteins, which trigger downstream signals culminating in caspase-3 activation followed by cell death. Crocin prevented the activation of nSMase by enhancing the transcription of gamma-glutamylcysteinyl synthase, which contributes to a stable glutathione supply that blocks the activity of nSMase.

Fórmula: C₄₄H₆₄O₂₄

Peso molecular: 976.9646

Ref: TM-TMSM-0823

Crocin

CAS: 42553-65-1

Fórmula: C₄₄H₆₄O₂₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 976.9646

Ref: IN-DA00BXRM

Crocin I

CAS: 42553-65-1

Crocin is a water-soluble carotenoid pigment of saffron (Crocus sativus L.), it has been used as a spice for flavoring and coloring food preparations. Crocin has anti-inflammatory, anti-oxidative, anti-apoptotic, anti-asthma, anti-cancer, and hypolipidemic effects. Crocin improves toxic effects of diazinon via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta; it also protects retinal photoreceptors against light-induced cell death. Crocin can also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.

Fórmula: C₄₄H₆₄O₂₄

Pureza: 95%~99%

Peso molecular: 976.972

Ref: BP-BP0406

Crocin

CAS: 42553-65-1

Stability Light Sensitive
Applications Crocin, is a natural carotenoid derived the flowers crocus and gardenia. Crocin has been shown to be a potent antioxidant. It has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties.
References Zheng, Y. Q., et al.: Brain Res., 1138, 86 (2006); Hosseinzadeh, H., et al.: PTR, 24 (5), 726 (2010); Ochiai, T., et al.: Biochim. Biophys. Acta., 1770(4), 578 (2006);

Fórmula: C₄₄H₆₄O₂₄

Cor e Forma: Neat

Peso molecular: 976.96

Ref: TR-C794945

Crocin

CAS: 42553-65-1

(2E,4E,6E,8E,10E,12E,14E)-Bis((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl) 2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate

Fórmula: C₄₄H₆₄O₂₄

Pureza: 95%

Peso molecular: 976.96

Ref: IN-DG38996

Crocin

CAS: 42553-65-1

Natural glycoside

Fórmula: C₄₄H₆₄O₂₄

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 976.98

Ref: 5G-80391

Crocin I

CAS: 42553-65-1

Fórmula: C₄₄H₆₄O₂₄

Cor e Forma: Solid

Peso molecular: 977.0

Ref: BE-BePure-21470

CrocinⅠ

CAS: 42553-65-1

Fórmula: C₄₄H₆₄O₂₄

Cor e Forma: Solid

Peso molecular: 977.0

Ref: BE-RMT19100

Crocin

CAS: 42553-65-1

Pureza: 95%

Peso molecular: 976.972

Ref: 10-F979316

Crocin I

CAS: 42553-65-1

Crocin is a pharmaceutical product which is an antipyretic and analgesic medication, primarily composed of paracetamol (acetaminophen). It is synthesized through chemical processes originally derived from coal tar, although modern production predominantly utilizes petrochemical sources. The mode of action of Crocin involves the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system. This action leads to a decrease in the synthesis of prostaglandins, which are responsible for pain and fever.

Fórmula: C₄₄H₆₄O₂₄

Pureza: Min. 98.0 Area-%

Cor e Forma: Powder

Peso molecular: 976.96 g/mol

Ref: 3D-OC08286

Crocin - microscopy grade

CAS: 42553-65-1

Crocin is a carotenoid found in the fruit of Crocus sativus. It has been shown to have potential anticancer activity, as well as antioxidant and anti-inflammatory properties. Crocin has demonstrated significant cytotoxicity against cancer cells in vitro. The mechanism of action is not fully understood, but it may be due to its ability to inhibit oxidative injury and receptor activity. Crocin has also been shown to have an effect on eye disorders such as retinitis pigmentosa and macular degeneration, which may be due to its antioxidant properties. The analytical method for crocin is high performance liquid chromatography (HPLC). HPLC separation is achieved using a reversed-phase column with gradient elution using water, acetonitrile and methanol. Preparative HPLC is used for isolation from natural sources.

Fórmula: C₄₄H₆₄O₂₄

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 976.96 g/mol

Ref: 3D-FC158408