CAS 461432-26-8
:Dapagliflozina
Descrição:
Dapagliflozina é um medicamento utilizado principalmente no manejo do diabetes mellitus tipo 2. Pertence à classe de medicamentos conhecidos como inibidores do cotransportador de sódio-glicose 2 (SGLT2), que atuam prevenindo a reabsorção de glicose nos rins, promovendo assim sua excreção na urina e reduzindo os níveis de glicose no sangue. A fórmula química de Dapagliflozina é C21H25ClO6S, e apresenta um grupo sulfonila, um grupo clorofenila e uma estrutura semelhante à glicose que facilita seu mecanismo de ação. Dapagliflozina é tipicamente administrado por via oral e muitas vezes é prescrito em conjunto com outros agentes antidiabéticos para melhorar o controle glicêmico. Além de seus efeitos redutores de glicose, tem sido associado à perda de peso e à redução da pressão arterial. Efeitos colaterais comuns podem incluir infecções do trato urinário e infecções micóticas genitais devido ao aumento de glicose na urina. No geral, Dapagliflozina representa um avanço significativo no tratamento do diabetes, oferecendo uma abordagem única para o manejo dos níveis de açúcar no sangue.
Fórmula:C21H25ClO6
InChI:InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
Chave InChI:InChIKey=JVHXJTBJCFBINQ-ADAARDCZSA-N
SMILES:O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC3=CC=C(OCC)C=C3)=C(Cl)C=C2
Sinónimos:- (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-<span class="text-smallcaps">D</span>-glucitol
- (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
- (1S)-1,5-anhydro-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol
- <span class="text-smallcaps">D</span>-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-, (1S)-
- Bms-512148
- D-Glucitol, 1,5-Anhydro-1-C-[4-Chloro-3-[(4-Ethoxyphenyl)Methyl]Phenyl]-, (1S)-
- Dapagliflozin
- Dapagliflozin free base
- (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
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Dapagliflozin
CAS:Fórmula:C21H25ClO6Pureza:>95.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:408.88(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol
CAS:Fórmula:C21H25ClO6Pureza:97%Cor e Forma:SolidPeso molecular:408.8726Ref: IN-DA0039GJ
1kgA consultar5gA consultar500gA consultar10mg27,00€50mg28,00€100mg49,00€250mg52,00€1g107,00€10g552,00€250g659,00€Dapagliflozin
CAS:Fórmula:C21H25ClO6Pureza:≥ 98.0% (dried basis)Cor e Forma:White to light-yellow powderPeso molecular:408.87Dapagliflozin (Standard)
CAS:Dapagliflozin (Standard) is the standard for Dapagliflozin (T2389). Dapagliflozin is a competitive sodium-glucose cotransporter 2 (SGLT2) inhibitor that can reduce renal glucose reabsorption and promote urinary glucose excretion. Dapagliflozin can also inhibit renal mesangial cell fibrosis by regulating the HO-1/TGF-β1/Smad2/3 axis, and is related to research on glucose transport, renal cell responses, and fibrosis signaling. Dapagliflozin can also be used in research on SGLT2 pharmacology and mechanisms of renal fibrosis-related pathways.Fórmula:C21H25ClO6Peso molecular:408.87Dapagliflozin
CAS:Stability Hygroscopic
Applications A sodium-glucose transporter 2 inhibitor.
References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)Fórmula:C21H25ClO6Cor e Forma:NeatPeso molecular:408.87Dapagliflozin
CAS:(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triolFórmula:C21H25ClO6Pureza:97%Peso molecular:408.87Dapagliflozin
CAS:Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.Fórmula:C21H25ClO6Pureza:99.5% - 99.97%Cor e Forma:SolidPeso molecular:408.87Dapagliflozin - Bio-X ™
CAS:Dapagliflozin is a sodium-glucose cotransporter subtype 2 (SGLT2) inhibitor that can be used in the treatment of diabetes mellitus type 2. It inhibits glucose reabsorption in the proximal tubule of the nephron and results in glycosuria, which helps to improve glycaemic control. Also, Dapagliflozin is used to lower the risk of sustained eGFR decline, end-stage renal disease, cardiovascular death, and hospitalization for heart failure in patients with chronic kidney disease who are at risk of progression.Fórmula:C21H25ClO6Pureza:Min. 99 Area-%Cor e Forma:PowderPeso molecular:408.87 g/molDapagliflozin
CAS:Dapagliflozin is a sodium-glucose cotransporter subtype 2 (SGLT2) inhibitor that can be used in the treatment of diabetes mellitus type 2. SGLT2 is located in the proximal convoluted tubule and when it is inhibited the reabsorption of glucose into the kidneys is prevented and instead glucose is excreted in the urine. As a result glucose levels are reduced. Dapagliflozin is metabolized into to its inactive metabolite 3-O-glucuronide by the UGT1A9 enzyme present in the liver and the kidneys. In addition, dapagliflozin has been shown to cause weight loss and decrease the risk of cardiovascular events such as congestive heart failure.Fórmula:C21H25ClO6Pureza:Min. 98 Area-%Cor e Forma:White Yellow PowderPeso molecular:408.87 g/mol
![(2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol](https://static.cymitquimica.com/products/IN/thumb/DA0039GJ.jpg)
