CAS 465-21-4

Bufalina

Descrição:

Bufalina é um potente glicosídeo cardíaco derivado da pele de sapos, particularmente da espécie Bufo. É classificado na categoria mais ampla de bufadienolídeos, que são conhecidos por sua capacidade de inibir a enzima Na+/K+ ATPase, levando ao aumento dos níveis de cálcio intracelular e à maior contratilidade cardíaca. Bufalina exibe uma variedade de atividades biológicas, incluindo propriedades anti-tumorais, anti-inflamatórias e antivirais, tornando-se um assunto de interesse na pesquisa farmacológica. O composto é tipicamente caracterizado por sua estrutura semelhante a esteroides, apresentando um anel de lactona e múltiplos grupos hidroxila, que contribuem para sua atividade biológica. Bufalina é lipofílico, permitindo que atravesse facilmente as membranas celulares, e tem sido estudado por suas potenciais aplicações terapêuticas, particularmente no tratamento de certos cânceres e condições cardíacas. No entanto, seu uso é limitado por sua toxicidade e potenciais efeitos colaterais, exigindo consideração cuidadosa em ambientes clínicos. No geral, Bufalina representa um exemplo fascinante de um produto natural com potencial farmacológico significativo.

Fórmula: C₂₄H₃₄O₄

InChI: InChI=1/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19?,20?,22+,23-,24+/m1/s1

Chave InChI: InChIKey=QEEBRPGZBVVINN-BMPKRDENSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C=3C=CC(=O)OC3)CC[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O)C5)[H])[H])[H]

Sinónimos:

• (3Beta,5Beta,8Xi,9Xi)-3,14-Dihydroxybufa-20,22-Dienolide
• (3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
• 3,14-Dihydroxybufa-20,22-Dienolide
• 5β-Bufa-20,22-dienolide, 3β,14-dihydroxy-
• B 0261
• Bufa-20,22-dienolide, 3,14-dihydroxy-, (3β,5β)-
• NSC 89595
• Bufalin
• Bufalin, >=98%
• 5BETA,20[22]-BUFADIENOLIDE-3BETA,14-DIOL
• 22-dienolide,3-beta,14-dihydroxy-5-beta-bufa-2
• 5-(3,14-Dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pyran-2-one
• Bufalin std.
• BUFALIN: BUFA-20,22-DIENOLIDE, 3,14-DIHYDROXY-, (3B,5B)-,
• Bufalin,3β,14-Dihydroxy-5β,20(22)-bufadienolide, 5β,20(22)-Bufadienolide-3β,14-diol
• 5-(3,14-Dihydroxy-13-methyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pyran-2-one
• 3β,14-Dihydroxy-5β,20(22)-bufadienolide
• 22-dienolide,3,14-dihydroxy-,(3-beta,5-beta)-bufa-2
• 5β,20(22)-Bufadienolide-3β,14-diol
• BUFALIN90%,99%
• (3β,5β)-3,14-Dihydroxy-bufa-20,22-dienolide
• Bufa-20,22-dienolide, 3,14-dihydroxy-, (3-beta,5-beta)-
• 3β,14-Dihydroxy-5β,20(22)-bufadienolide, 5β,20(22)-Bufadienolide-3β,14-diol
• 3BETA,14-DIHYDROXY-5BETA,20[22]-BUFADIENOLIDE
• 3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide
• 3-BETA-14-DIHYDROXY-5-BETA-BUFA-20,22-DIENOLIDE

(3β,5β)-3,14-Dihydroxybufa-20,22-dienolide

CAS: 465-21-4

Fórmula: C₂₄H₃₄O₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 386.5244

Ref: IN-DA00I8KR

Bufalin

CAS: 465-21-4

Bufalin

Pureza: ≥98%

Peso molecular: 386.52g/mol

Ref: 54-BUP13200

Bufalin

CAS: 465-21-4

Bufalin a major digoxin-like immunoreactive component of the Chinese medicine Chan Su; has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators steroid receptor coactivator (SRC)-3 and SRC-1, it also as a potentially broad-spectrum small-molecule inhibitor for cancer. Bufalin can partly reverse the MDR of K562/VCR cells, with a possible mechanism of down-regulating MRP1 expression and activating apoptosis pathway by altering Bcl-xL/Bax ratio.

Fórmula: C₂₄H₃₄O₄

Pureza: 95%~99%

Peso molecular: 386.532

Ref: BP-BP0288

Bufalin

CAS: 465-21-4

Bufalin: a cardiotonic, antineoplastic glycoside in ChanSu; from toad venom; inhibits Na+/K+-ATPase, triggers apoptosis via MAPK pathway.

Fórmula: C₂₄H₃₄O₄

Pureza: 98% - 99.8%

Cor e Forma: White Solid

Peso molecular: 386.52

Ref: TM-T1719

Bufalin

CAS: 465-21-4

Fórmula: C₂₄H₃₄O₄

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 386.52

Ref: 7W-GL7257

Bufalin

CAS: 465-21-4

Lactone

Fórmula: C₂₄H₃₄O₄

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 386.53

Ref: 5G-89587

Bufalin

CAS: 465-21-4

Pureza: 99.86%

Peso molecular: 386.532

Ref: 10-F048876

Bufalin

CAS: 465-21-4

Applications A bufadienolide derivative, cardiac steroid, a component of bufadienolides present in the traditional Chinese medicine Chan'su, used therapeutically for the treatment of heart disease, also has been reported as a protective factor in many tumors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, B., et al.: Biol. Pharm. Bull., 34, 967 (2011), Song, C., et al.: Xiandai Zhongliu Yixue, 18, 1863, 2010.

Fórmula: C₂₄H₃₄O₄

Cor e Forma: Neat

Peso molecular: 386.52

Ref: TR-B689510

Bufalin

CAS: 465-21-4

Bufalin is a bufadienolide compound, which is a type of steroid derived primarily from toad venom, specifically from the skin and parotid venom glands of the toad species Bufo gargarizans. Its mode of action involves the inhibition of Na+/K+-ATPase, an enzyme critical for maintaining the electrochemical gradient across cell membranes. By disrupting this gradient, Bufalin affects cellular ion homeostasis and induces apoptosis in various cancer cell lines.

Fórmula: C₂₄H₃₄O₄

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 386.52 g/mol

Ref: 3D-FB19349

Bufalin-2,2,3,4,4-d5

Produto Controlado

CAS: 465-21-4

Applications Isotope labelled Bufalin (B689510) is a Bufadienolide derivative, cardiac steroid, a component of bufadienolides present in the traditional Chinese medicine Chan'su, used therapeutically for the treatment of heart disease, also has been reported as a protective factor in many tumors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, B., et al.: Biol. Pharm. Bull., 34, 967 (2011), Song, C., et al.: Xiandai Zhongliu Yixue, 18, 1863, 2010.

Fórmula: C₂₄H₂₉D₅O₄

Cor e Forma: Neat

Peso molecular: 391.56

Ref: TR-B689512