CAS 47931-85-1

Calcitonina (salmão)

Descrição:

Calcitonina (salmão) é um hormônio peptídico que desempenha um papel crucial na homeostase do cálcio e no metabolismo ósseo. É derivado da espécie de salmão, que possui uma forma mais potente em comparação com a calcitonina humana. Esta substância é composta por 32 aminoácidos e é conhecida por sua capacidade de reduzir os níveis de cálcio no sangue ao inibir a atividade dos osteoclastos, o que reduz a reabsorção óssea. A calcitonina também promove a excreção renal de cálcio e fosfato, contribuindo ainda mais para seus efeitos hipocalcêmicos. É comumente utilizada em ambientes clínicos para o tratamento de condições como a osteoporose e a doença de Paget. O número CAS 47931-85-1 identifica de forma única esta formulação específica de calcitonina. Em termos de propriedades físicas, Calcitonina (salmão) é tipicamente administrado por injeção devido à sua natureza peptídica, que limita sua biodisponibilidade quando tomado por via oral. Seus efeitos terapêuticos são geralmente rápidos, tornando-o uma opção valiosa no manejo da hipercalcemia e distúrbios relacionados.

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

InChI: InChI=1/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)

SMILES: CC(C)CC(C(=NCC(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CO)C(=NC(CCC(=N)O)C(=NC(CCC(=O)O)C(=NC(CC(C)C)C(=NC(Cc1cnc[nH]1)C(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(C(C)O)C(=NC(Cc1ccc(cc1)O)C(=O)N1CCCC1C(=NC(CCCNC(=N)N)C(=NC(C(C)O)C(=NC(CC(=N)O)C(=NC(C(C)O)C(=NCC(=NC(CO)C(=NCC(=NC(C(C)O)C(=O)N1CCCC1C(=N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(C(C)C)N=C(C1CSSCC(C(=NC(CO)C(=NC(CC(=N)O)C(=NC(CC(C)C)C(=NC(CO)C(=NC(C(C)O)C(=N1)O)O)O)O)O)O)N)O)O

Sinónimos:

• Calcitonin (salmon I)
• Thyrocalcitonin Salmon
• H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 (Disulfide bond)
• Thyrocalcitonin
• Salmon calcitonin
• Salcitonin
• Salmon Calcitonin acetate
• Salmon
• Calcitonin salmon Acetate
• Calciben
• Calcimar
• Calcitonin (Lachs)
• Calcitonin (salmon reduced) cyclic (1→7)-disulfide
• Calcitonina (Salmon)
• Calcitonine (Saumon)
• Calsyn
• Calsynar
• Catonin
• Karil
• L-Prolinamide, L-cysteinyl-L-seryl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-, cyclic (1→7)-disulfide
• Miacalcic
• Miacalcin
• Miadenil
• Prontocalcin
• Rulicalcin
• Salcatonin
• Salmon calcitonin I
• Salmon calcitonin-(1-32)
• Salmon Thyrocalcitonin
• Salmotonin
• Stalcin
• Tonocalcin
• Calcitonin(Salmone) Acetate

Calcitonin (salmon I)

CAS: 47931-85-1

Calcitonin inhibits osteoclast activity, lowers the blood calcium level, and positively influences bone mass density. Salmon calcitonin (sCT) is more potent than the human analog. sCT may act as an amylin agonist (Wielinga et al.). In animal studies, administration of sCT was shown to reduce food intake.

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Pureza: 99.3%

Cor e Forma: White Lyophilisate

Peso molecular: 3431.9

Ref: 01-4033011

CALCITONIN-GLY CRS

CAS: 115472-96-3, 47931-85-1

CALCITONIN-GLY CRS

Ref: 41-Y0000632

CALCITONIN (SALMON) CRS

CAS: 47931-85-1

CALCITONIN (SALMON) CRS

Fórmula: C₈H₆BrN

Peso molecular: 196.0439

Ref: 41-C0200000

Calcitonin Salmon

CAS: 47931-85-1

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Cor e Forma: White Off-White Powder

Peso molecular: 3429.71331

Ref: 45-1086200

Calcitonin (Salmon)

CAS: 47931-85-1

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Peso molecular: 3431.90

Ref: 4Z-PC-322001

Calcitonin Salmon

CAS: 47931-85-1

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Pureza: >95.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 3,431.90

Ref: 3B-C3597

Calcitonin (salmon)

CAS: 47931-85-1

Calcitonin (salmon), a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Pureza: 99.41% - 99.80%

Cor e Forma: Powder

Peso molecular: 3431.85

Ref: TM-TP1040

Calcitonin Acetate(Salmon)

CAS: 47931-85-1

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Pureza: 95%~99%

Cor e Forma: White to Off-white Powder

Peso molecular: 3431.85

Ref: BP-BPPG013

Calcitonin Salmon RS

CAS: 47931-85-1, 5989-81-1

Cor e Forma: White Solid

Ref: 2K-1039500021

Calcitonin, Salmon

CAS: 47931-85-1

Applications Calcitonin, Salmon is a calcium regulating hormone which exhibits hypocalcaemic and hypophosphatemic properties.

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Cor e Forma: Neat

Peso molecular: 3431.85

Ref: TR-C144558

N-Acetyl-cys(1)-calcitonin Salmon Trifluoroacetic Acid Salt

Produto Controlado

CAS: 47931-85-1

Applications N-Acetyl-cys(1)-calcitonin Salmon is a derivative of Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
References Boron, WF., et al.: Med. Physi., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Fórmula: C₁₄₇H₂₄₃N₄₄O₄₉S₂·x(C₂HF₃O₂)

Cor e Forma: Neat

Peso molecular: 3475.5911402

Ref: TR-A168465

Calcitonin (salmon) xAcetate

Produto Controlado

CAS: 47931-85-1

Applications Calcitonin (salmon), is a 32-amino acid linear polypeptide hormone that is produced in thyroid in humans. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
References Boron, WF. et al.: Med. Phys., A Cellular and Molecular Approach (2004); Andreotti, G. et al.: J. Bio. Chem., 281, 24193 (2006);

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂·x(CH₃CO₂H)

Cor e Forma: Neat

Peso molecular: 3431.856005

Ref: TR-C144555

Calcitonin

CAS: 47931-85-1

Calcitonin is a peptide hormone that inhibits the release of calcium from bone, and decreases the blood level of calcium. Calcitonin is not active in the absence of parathyroid hormone (PTH) or vitamin D. It has been shown to inhibit the development of experimental myocardial infarcts in rats by inhibiting the release of calcium from bone, and has also been shown to have a protective effect on brain function. The calcitonin receptor is activated by binding with calcitonin, which then activates adenylyl cyclase and increases intracellular cAMP levels. This leads to increased activity at ATP-sensitive potassium channels, which causes hyperpolarisation of neurons. Caudate putamen neurons are particularly sensitive to calcitonin activity because they are rich in voltage-gated K+ channels that are sensitive to ATP-sensitive potassium channel activation. Calcitonin also plays a role in regulating serum Ca2+ concentration by inhib

Fórmula: C₁₄₅H₂₄₀N₄₄O₄₈S₂

Pureza: Min. 95%

Peso molecular: 3,431.86 g/mol

Ref: 3D-FC36651

Calcitonin (salmon)

CAS: 47931-85-1

Calcitonin (salmon)

Cor e Forma: White Powder

Ref: 47-355