CAS 480-11-5

Oroxilina A

Descrição:

Oroxilina A, com o número CAS 480-11-5, é um composto flavonoide encontrado principalmente em várias plantas, particularmente nas raízes da erva medicinal Scutellaria baicalensis. É caracterizado por sua cor amarelada e é conhecido por suas diversas atividades biológicas, incluindo propriedades antioxidantes, anti-inflamatórias e neuroprotetoras. Estruturalmente, Oroxilina A apresenta uma estrutura de flavona, que contribui para sua capacidade de interagir com vários alvos biológicos. Este composto tem despertado interesse na pesquisa farmacológica devido aos seus potenciais efeitos terapêuticos, incluindo seu papel na modulação de vias de sinalização relacionadas à sobrevivência celular e à apoptose. Além disso, Oroxilina A tem sido estudado por seus efeitos na função cognitiva e seu potencial uso no tratamento de doenças neurodegenerativas. Sua solubilidade em solventes orgânicos e a limitada solubilidade em água são características importantes que influenciam sua biodisponibilidade e aplicação em formulações medicinais. No geral, Oroxilina A representa um composto significativo no campo dos produtos naturais e da farmacognosia, com pesquisas em andamento destinadas a elucidar seu completo potencial terapêutico.

Fórmula: C₁₆H₁₂O₅

InChI: InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3

Chave InChI: InChIKey=LKOJGSWUMISDOF-UHFFFAOYSA-N

SMILES: OC1=C2C(OC(=CC2=O)C3=CC=CC=C3)=CC(O)=C1OC

Sinónimos:

• 4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl-
• 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one
• 5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one
• 6-Methoxybaicalein
• Baicalein 6-methyl ether
• Flavone, 5,7-dihydroxy-6-methoxy-
• Oroxylin
• oroxylin A

Oroxylin A

CAS: 480-11-5

Fórmula: C₁₆H₁₂O₅

Pureza: >98.0%(HPLC)(T)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 284.27

Ref: 3B-O0635

Oroxylin A

CAS: 480-11-5

Oroxylin A

Fórmula: C₁₆H₁₂O₅

Pureza: 99.5%

Cor e Forma: Solid

Peso molecular: 284.26

Ref: 54-BUP00041

5,7-Dihydroxy-6-Methoxy-2-Phenyl-4H-Chromen-4-One

CAS: 480-11-5

5,7-Dihydroxy-6-Methoxy-2-Phenyl-4H-Chromen-4-One

Fórmula: C₁₆H₁₂O₅

Pureza: 98%

Peso molecular: 284.26

Ref: 54-OR1027911

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one

CAS: 480-11-5

Fórmula: C₁₆H₁₂O₅

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 284.2635

Ref: IN-DA003THU

Oroxylin A (Standard)

CAS: 480-11-5

Oroxylin A (Standard) is a reference standard for research and analysis in studies involving Oroxylin A. 1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.

Fórmula: C₁₆H₁₂O₅

Peso molecular: 284.2635

Ref: TM-TMSM-2618

Oroxylin A

CAS: 480-11-5

Oroxylin A has anticancer,.anti-inflammation, antithrombotic,antibacterial, anti-pruritic effects, it can inhibit LPS-induced iNOS and COX-2 gene expression by blocking NF-κB activation. Oroxylin A reverses MDR by G2/M arrest and the underlying mechanism attributed to the suppression of P-gp expression via Chk2/P53/NF-κB signaling pathway. Oroxylin A facilitates memory consolidation through brain-derived neurotrophic factor (BDNF)-TrkB signaling.

Fórmula: C₁₆H₁₂O₅

Pureza: 95%~99%

Peso molecular: 284.267

Ref: BP-BP1045

Oroxylin A

CAS: 480-11-5

Fórmula: C₁₆H₁₂O₅

Pureza: ≥ 95.0%

Cor e Forma: Pale yellow to yellow powder

Peso molecular: 284.26

Ref: 7W-GL6913

Oroxylin A

CAS: 480-11-5

Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.

Fórmula: C₁₆H₁₂O₅

Pureza: 98.72% - 99.98%

Cor e Forma: White Solid

Peso molecular: 284.2635

Ref: TM-T6S1315

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one

CAS: 480-11-5

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one

Fórmula: C₁₆H₁₂O₅

Pureza: 98%

Peso molecular: 284.26

Ref: IN-DG146312

Oroxylin A

CAS: 480-11-5

Oxygen-heterocyclic compound

Fórmula: C₁₆H₁₂O₅

Pureza: ≥ 90.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 284.27

Ref: 5G-82615

Oroxylin A

CAS: 480-11-5

Oroxylin A is a natural flavonoid compound, which is derived from the root of Scutellaria baicalensis, commonly known as Baikal skullcap. It is primarily recognized for its bioactive properties, attributed to its modulation of various biochemical pathways. Oroxylin A acts by inhibiting the activity of certain enzymes, such as cyclooxygenase, and influencing signaling pathways like NF-kB, which are integral to inflammatory responses. It also exhibits potent neuroprotective effects by interacting with GABA_A receptors, thereby influencing neurotransmission.

Fórmula: C₁₆H₁₂O₅

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 284.26 g/mol

Ref: 3D-FO63225

Oroxylin A

CAS: 480-11-5

Fórmula: C₁₆H₁₂O₅

Peso molecular: 284.26

Ref: BE-RMT12156

OROXYLIN A

CAS: 480-11-5

Pureza: 97%

Peso molecular: 284.2669983

Ref: 10-F809645