CAS 495-85-2

(+)-Methysticin

Descrição:

(+)-Methysticin é um composto que ocorre naturalmente classificado como um flavonoide, especificamente um derivado da metisticina, encontrado principalmente na espécie de planta *Piper methysticum*, comumente conhecida como kava. Este composto é conhecido por suas propriedades psicoativas e tem sido tradicionalmente utilizado em várias culturas por seus efeitos calmantes e ansiolíticos. Quimicamente, apresenta uma estrutura complexa que inclui uma espinha dorsal de cromona, contribuindo para sua atividade biológica. (+)-Methysticin exibe propriedades antioxidantes e tem sido estudado por seus potenciais efeitos terapêuticos, incluindo atividades anti-inflamatórias e neuroprotetoras. O composto é tipicamente caracterizado por sua solubilidade em solventes orgânicos e solubilidade limitada em água. Seu perfil farmacológico sugere que pode interagir com sistemas de neurotransmissores, embora mais pesquisas sejam necessárias para elucidar completamente seus mecanismos de ação e potenciais benefícios à saúde. Assim como muitos produtos naturais, a segurança e eficácia de (+)-Methysticin em aplicações terapêuticas requerem consideração cuidadosa e investigação adicional.

Fórmula: C₁₅H₁₄O₅

InChI: InChI=1S/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+/t11-/m0/s1

Chave InChI: InChIKey=GTEXBOVBADJOQH-FWEMWIAWSA-N

SMILES: C(=C/[C@H]1CC(OC)=CC(=O)O1)\C=2C=C3C(=CC2)OCO3

Sinónimos:

• (+)-Methysticin
• (6R)-6-[(1E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one
• (6R)-6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
• (6R)-6-[(E)-2-(1,3-benzodioxol-5-yl)vinyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
• 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[3,4-(methylenedioxy)styryl]-, (R)-
• 2H-Pyran-2-one, 6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6R)-
• 2H-Pyran-2-one, 6-[2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, [R-(E)]-
• 2H-pyran-2-one, 6-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6R)-
• 4-Methoxy-6-[b-(3',4'-methylenedioxyphenyl)vinyl]-5,6-dihydro-a-pyrone
• 5-Hydroxy-3-methoxy-7-[3,4-(methylenedioxy)phenyl]-2,6-heptadienoic Acid d-Lactone
• 6-(3',4'-Methylenedioxystyryl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
• Kavahin
• Kavatin
• Methylsticin
• NSC 112158
• [R-(E)]-6-[2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one

Methylsticin

CAS: 495-85-2

Methylsticin

Fórmula: C₁₅H₁₄O₅

Pureza: ≥98%

Peso molecular: 274.272

Ref: 54-BUP03119

Methysticin

CAS: 495-85-2

Fórmula: C₁₅H₁₄O₅

Peso molecular: 274.27

Ref: 7W-GY0145

Methylsticin

CAS: 495-85-2

Fórmula: C₁₅H₁₄O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 274.2687

Ref: IN-DA00DA4R

Methysticin

CAS: 495-85-2

Fórmula: C₁₅H₁₄O₅

Pureza: 95%~99%

Peso molecular: 274.272

Ref: BP-BP0945

Methylsticin (Standard)

CAS: 495-85-2

Methylsticin (Standard) is a reference standard for research and analysis in studies involving Methylsticin. Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neurons and astroglia, decreases peak amplitude of voltage-gated Na+ channels in hippocampal neurons, and suppresses growth of Fusarium, Trichoderma, and Colletotrichum.

Fórmula: C₁₅H₁₄O₅

Peso molecular: 274.2687

Ref: TM-TMSM-2511

Kavatin

Produto Controlado

CAS: 495-85-2

Applications A lactone isolated from the Kava plant (Piper methysticum). The active constituents of Kava are a group of approx. 18 compounds collectively referred to as kavalactones or kava pyrones. One of the active components of the intoxicating beverage Kava from the Pacific Islands.
References Keledjian, J., et al.: J. Pharm. Sci., 77, 1003 (1988), Clouatre, D., et al.: Toxicol. Lett., 150, 85 (2004), Mathews, J., et al.: Drug Metab. Dispos., 33, 1555 (2005), Clayton, N., et al.: Exp. Toxicol. Pathol., 58, 223 (2007),

Fórmula: C₁₅H₁₄O₅

Cor e Forma: Neat

Peso molecular: 274.27

Ref: TR-K145500

Methylsticin

CAS: 495-85-2

Methysticin, a kavalactone from kava roots, inhibits osteoclasts, NF-χB, stimulates Nrf2, reduces Na+ channel peaks, and hinders fungal growth.

Fórmula: C₁₅H₁₄O₅

Pureza: 99.27% - 99.37%

Cor e Forma: White Powder

Peso molecular: 274.2687

Ref: TM-TN2347

Methysticin

CAS: 495-85-2

Fórmula: C₁₅H₁₄O₅

Peso molecular: 274.27

Ref: 4Z-M-236002

Methysticin

CAS: 495-85-2

Lactone

Fórmula: C₁₅H₁₄O₅

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 274.27

Ref: 5G-89250

Methysticin

CAS: 495-85-2

Methysticin is one of the major kavalactones found in the roots of the kava plant, which is scientifically known as *Piper methysticum*. This compound is derived from the rhizomes of the South Pacific plant, where it exists alongside other kavalactones that collectively contribute to the plant’s bioactive profile. Methysticin's primary mode of action is believed to involve modulation of neurotransmitter systems, particularly through interactions with GABAergic pathways, leading to its anxiolytic and sedative effects.

Fórmula: C₁₅H₁₄O₅

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 274.27 g/mol

Ref: 3D-FM69761

Methysticin

CAS: 495-85-2

Fórmula: C₁₅H₁₄O₅

Peso molecular: 274.27

Ref: BE-RMT12512