CAS 50773-41-6

Polifilina A

Descrição:

Polifilina A é uma saponina esteroidal natural derivada principalmente da espécie vegetal Paris polyphylla, conhecida por seus usos medicinais tradicionais. Este composto é caracterizado por sua complexa estrutura glicosídica, que inclui uma estrutura esteroide ligada a múltiplos moieties de açúcar. Polifilina A exibe uma variedade de atividades biológicas, incluindo propriedades anti-inflamatórias, anticancerígenas e antimicrobianas, tornando-se um assunto de interesse na pesquisa farmacológica. Seu mecanismo de ação muitas vezes envolve a indução de apoptose em células cancerosas e a modulação de várias vias de sinalização. Além disso, Polifilina A é conhecido por seu potencial de aumentar a biodisponibilidade de outros agentes terapêuticos. No entanto, seu uso é acompanhado de considerações sobre toxicidade e efeitos colaterais, exigindo mais estudos para entender completamente seu perfil de segurança e potencial terapêutico. No geral, Polifilina A representa um composto significativo no campo dos produtos naturais e da química medicinal, destacando a importância das substâncias derivadas de plantas na descoberta de medicamentos.

Fórmula: C₄₄H₇₀O₁₆

InChI: InChI=1S/C44H70O16/c1-19-8-13-44(53-18-19)20(2)30-27(60-44)15-26-24-7-6-22-14-23(9-11-42(22,4)25(24)10-12-43(26,30)5)55-41-38(59-39-35(51)33(49)31(47)21(3)54-39)36(52)37(29(17-46)57-41)58-40-34(50)32(48)28(16-45)56-40/h6,19-21,23-41,45-52H,7-18H2,1-5H3/t19-,20+,21+,23+,24-,25+,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36+,37-,38-,39+,40+,41-,42+,43+,44-/m1/s1

Chave InChI: LRRDDWMXYOSKIC-IPKCVOQPSA-N

SMILES: C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@H]([C@@H](O8)CO)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)C)C)OC1

Sinónimos:

• Paris saponin Pa
• Polyphillin D
• Polyphyllin D
• Polyphyllin I
• Chonglou Saponin I

Polyphyllin D

CAS: 50773-41-6

Fórmula: C₄₄H₇₀O₁₆

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 855.0170

Ref: IN-DA00DA54

Polyphyllin I

CAS: 50773-41-6

Polyphyllin I

Fórmula: C₄₄H₇₀O₁₆

Pureza: ≥98%

Peso molecular: 855.02

Ref: 54-BUP06481

Polyphyllin I

CAS: 50773-41-6

Fórmula: C₄₄H₇₀O₁₆

Peso molecular: 855.03

Ref: 7W-GY0490

Polyphyllin I

CAS: 50773-41-6

Polyphyllin D has anti-angiogenic, and anticancer effects, it induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C and cleaved-caspase-3 levels.Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis.

Fórmula: C₄₄H₇₀O₁₆

Pureza: 95%~99%

Cor e Forma: Powder

Peso molecular: 855.028

Ref: BP-BP3323

Polyphyllin I (Standard)

CAS: 50773-41-6

Polyphyllin I (Standard) is a reference standard for research and analysis in studies involving Polyphyllin I. Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.

Fórmula: C₄₄H₇₀O₁₆

Cor e Forma: Solid

Peso molecular: 855.017

Ref: TM-TMSM-3126

Polyphyllin I

Produto Controlado

CAS: 50773-41-6

Applications Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers.
References Ma, D. et al.: J. Int Med. Res., 37, 631 (2009); Yin, X. et al.: Biomed. Chrom., 27, 343 (2013); Jiang, H. et al.: Mol. Med. Rep., 9, 2265 (2014);

Fórmula: C₂₇H₂₉F₃O₆S

Cor e Forma: Neat

Peso molecular: 538.576

Ref: TR-P689455

Polyphyllin I

CAS: 50773-41-6

Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,

Fórmula: C₄₄H₇₀O₁₆

Pureza: 98% - 99.36%

Cor e Forma: Solid

Peso molecular: 855.017

Ref: TM-T3895

Polyphyllin D

CAS: 50773-41-6

Natural glycoside

Fórmula: C₄₄H₇₀O₁₆

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 855.02

Ref: 5G-80560

Polyphyllin D

CAS: 50773-41-6

Polyphyllin D is a natural compound, which is a steroidal saponin extracted from the rhizome of Paris polyphylla, a traditional Chinese medicinal plant. It exhibits significant biological activities and has garnered interest for its potential therapeutic applications. Polyphyllin D exerts its effects primarily through the disruption of cellular processes, including the induction of apoptosis, modulation of the cell cycle, and inhibition of angiogenesis. It achieves these actions by influencing multiple molecular pathways, such as the mitochondrial apoptotic pathway and autophagy regulation.

Fórmula: C₄₄H₇₀O₁₆

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 855.02 g/mol

Ref: 3D-OP42701

Chonglou saponin I

CAS: 50773-41-6

Fórmula: C₄₄H₇₀O₁₆

Peso molecular: 855.0

Ref: BE-RMT26570

Polyphyllin I

CAS: 50773-41-6

(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-(((2S,3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-4-hydroxy-6-(hydroxymethyl)-2-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol

Fórmula: C₄₄H₇₀O₁₆

Pureza: 99%

Peso molecular: 855.02

Ref: IN-DG298718