CAS 53-86-1
:Indometacina
Descrição:
Indometacina é um medicamento anti-inflamatório não esteroidal (AINE) usado principalmente para aliviar a dor, o inchaço e a inflamação associados a várias condições, como artrite e gota. É classificado como um derivado do ácido indolacético e exibe potentes propriedades anti-inflamatórias e analgésicas. A fórmula química de Indometacina é C19H16ClN e tem um peso molecular de aproximadamente 357,79 g/mol. Indometacina funciona inibindo as enzimas ciclooxigenases (COX), que desempenham um papel crucial na síntese de prostaglandinas, mediadores da inflamação e da dor. A substância é tipicamente administrada por via oral, mas também pode ser administrada retalmente ou intravenosamente. Indometacina é conhecido por seus potenciais efeitos colaterais, que podem incluir problemas gastrointestinais, riscos cardiovasculares e comprometimento renal, exigindo monitoramento cuidadoso durante o uso. Sua solubilidade é moderada em água, mas é mais solúvel em solventes orgânicos, o que influencia sua formulação em preparações farmacêuticas. No geral, Indometacina continua sendo um importante agente terapêutico no manejo de condições inflamatórias.
Fórmula:C19H16ClNO4
InChI:InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
Chave InChI:InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3
Sinónimos:- 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
- 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
- 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
- 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
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- Nsc 77541
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- [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
- {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate
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Indomethacin
CAS:Fórmula:C19H16ClNO4Pureza:>98.0%(T)(HPLC)Cor e Forma:White to Light yellow to Light orange powder to crystalPeso molecular:357.79Indomethacin, 98%
CAS:<p>It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also p</p>Fórmula:C19H16ClNO4Pureza:98%Cor e Forma:White to pale cream, PowderPeso molecular:357.79Indomethacin, 99+%
CAS:<p>Indomethacin, 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID) that inhibits cyclooxygenases and enhances the effects of antineoplastic agents. Learn more.</p>Fórmula:C19H16ClNO4Pureza:99+%Peso molecular:357.8INDOMETACIN IMPURITY MIXTURE CRS
CAS:INDOMETACIN IMPURITY MIXTURE CRSFórmula:C17H19N3Peso molecular:265.3529INDOMETACIN CRS
CAS:INDOMETACIN CRSFórmula:C17H19N3Cor e Forma:Crystalline Powder. White. Yellow. Powder.Peso molecular:265.3529Indomethacin
CAS:Analgesics, antipyretics and non-hormonal anti-inflammatory agentsFórmula:C19H16ClNO4Cor e Forma:White Yellow PowderPeso molecular:357.79Indomethacin
CAS:Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.Fórmula:C19H16ClNO4Pureza:99.27% - 99.76%Cor e Forma:Pale-Yellow To Yellow-Tan Crystalline Powder Physical Description Crystals (Ntp 1992)Peso molecular:357.79Indomethacin
CAS:Fórmula:C19H16ClNO4Pureza:≥ 98.0% (dried basis)Cor e Forma:White to off-white or pale pink powderPeso molecular:357.80Indomethacin, BP grade
CAS:Fórmula:C19H16ClNO4Pureza:(Titration) 98.5 - 100.5 % (dried basis)Cor e Forma:White to yellow powder or crystalsPeso molecular:357.80Indomethacin (Indometacin) EP Impurity D
CAS:Fórmula:C19H16ClNO4Cor e Forma:White To Off-White SolidPeso molecular:357.79Indomethacin
CAS:Produto Controlado<p>Impurity Acemetacin EP Impurity B<br>Applications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)<br></p>Fórmula:C19H16ClNO4Cor e Forma:BeigePeso molecular:357.79Indomethacin
CAS:<p>Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin also has significant cytotoxicity in vitro and produces a dose-dependent reduction in polymorphonuclear leucocytes (PMNs). Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to indomethacin's anti-inflammatory effects.</p>Fórmula:C19H16ClNO4Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:357.79 g/molIndomethacin - Bio-X ™
CAS:<p>Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to Indomethacin's anti-inflammatory effects. Indomethacin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Fórmula:C19H16ClNO4Pureza:(%) Min. 95%Cor e Forma:PowderPeso molecular:357.79 g/mol
