CAS 53-86-1

Indometacina

Descrição:

Indometacina é um medicamento anti-inflamatório não esteroidal (AINE) usado principalmente para aliviar a dor, o inchaço e a inflamação associados a várias condições, como artrite e gota. É classificado como um derivado do ácido indolacético e exibe potentes propriedades anti-inflamatórias e analgésicas. A fórmula química de Indometacina é C19H16ClN e tem um peso molecular de aproximadamente 357,79 g/mol. Indometacina funciona inibindo as enzimas ciclooxigenases (COX), que desempenham um papel crucial na síntese de prostaglandinas, mediadores da inflamação e da dor. A substância é tipicamente administrada por via oral, mas também pode ser administrada retalmente ou intravenosamente. Indometacina é conhecido por seus potenciais efeitos colaterais, que podem incluir problemas gastrointestinais, riscos cardiovasculares e comprometimento renal, exigindo monitoramento cuidadoso durante o uso. Sua solubilidade é moderada em água, mas é mais solúvel em solventes orgânicos, o que influencia sua formulação em preparações farmacêuticas. No geral, Indometacina continua sendo um importante agente terapêutico no manejo de condições inflamatórias.

Fórmula: C₁₉H₁₆ClNO₄

InChI: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

Chave InChI: InChIKey=CGIGDMFJXJATDK-UHFFFAOYSA-N

SMILES: C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3

Sinónimos:

• 1-(4-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
• 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
• 1-(4-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
• 1-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
• 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-acetic acid
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid
• 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• Aconip
• Amuno
• Argun
• Artracin
• Artrinovo
• Artrivia
• Bonidin
• Bonidon Gel
• Catlep
• Chibro-Amuno
• Chrono-Indicid
• Chrono-Indocid 75
• Confortid
• Dolcidium
• Dolcidium PL
• Dolovin
• Durametacin
• Elmetacin
• Endol
• Flam
• Globa
• Idomethine
• Imbrilon
• Inacid
• Indacin
• Indo-Phlogont
• Indo-Rectolmin
• Indo-Tablinen
• IndoRich
• Indocid
• Indocid (pharmaceutical)
• Indocin
• Indocine
• Indocollyre
• Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-
• Indomecol
• Indomed
• Indomee
• Indometacin
• Indometacina
• Indometacine
• Indomethacin Crystalline
• Indomethacin Methanol Solution
• Indomethacin Powder
• Indomethacin Usp
• Indomethacine
• Indomethine
• Indomod
• Indonol
• Indoptic
• Indoptol
• Indorektal
• Indoxen
• Indren
• Inflazon
• Infrocin
• Innamit
• Inteban
• Inteban SP
• Lausit
• Metacen
• Metartril
• Methazine
• Metindol
• Mezolin
• Microcid
• Mikametan
• Mobilan
• N-(p-Chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetic acid
• Nsc 77541
• Reumacide
• Rheumacin LA
• Sadoreum
• Tannex
• Vital Vitacid
• Vonum
• [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
• {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate

Indomethacin

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Pureza: >98.0%(HPLC)(T)

Cor e Forma: White to Light yellow to Light orange powder to crystal

Peso molecular: 357.79

Ref: 3B-I0655

Indomethacin, 99+%

CAS: 53-86-1

Indomethacin, 53-86-1, is an indole-based nonsteroidal anti-inflammatory (NSAID) that inhibits cyclooxygenases and enhances the effects of antineoplastic agents. Learn more.

Fórmula: C₁₉H₁₆ClNO₄

Pureza: 99+%

Peso molecular: 357.8

Ref: 02-J63255

Indomethacin, 98%

CAS: 53-86-1

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also p

Fórmula: C₁₉H₁₆ClNO₄

Pureza: 98%

Cor e Forma: Powder, White to pale cream

Peso molecular: 357.79

Ref: 02-A19910

INDOMETACIN IMPURITY MIXTURE CRS

CAS: 53-86-1

INDOMETACIN IMPURITY MIXTURE CRS

Fórmula: C₁₇H₁₉N₃

Peso molecular: 265.3529

Ref: 41-Y0001640

INDOMETACIN CRS

CAS: 53-86-1

INDOMETACIN CRS

Fórmula: C₁₇H₁₉N₃

Cor e Forma: Crystalline Powder. White. Yellow. Powder.

Peso molecular: 265.3529

Ref: 41-I0200000

Indomethacin

CAS: 53-86-1

Analgesics, antipyretics and non-hormonal anti-inflammatory agents

Fórmula: C₁₉H₁₆ClNO₄

Cor e Forma: White Yellow Powder

Peso molecular: 357.07679

Ref: 45-1341001

Indomethacin

CAS: 53-86-1

Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.

Fórmula: C₁₉H₁₆ClNO₄

Pureza: 99.27% - 99.76%

Cor e Forma: White Solid

Peso molecular: 357.788

Ref: TM-T0458

Indomethacin (Indometacin) EP Impurity D

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Cor e Forma: White To Off-White Solid

Peso molecular: 357.79

Ref: 4Z-I-1212

Indomethacin

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Pureza: ≥ 98.0% (dried basis)

Cor e Forma: White to off-white or pale pink powder

Peso molecular: 357.80

Ref: 7W-GA3090

Indomethacin

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Cor e Forma: White To Off-White Solid

Peso molecular: 357.79

Ref: 4Z-I-121

Indomethacin

CAS: 53-86-1

Indomethacin

Fórmula: C₁₉H₁₆ClNO₄

Pureza: ≥98%

Peso molecular: 357.79

Ref: 54-BUP19211

Indomethacin, BP grade

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Pureza: (Titration) 98.5 - 100.5 % (dried basis)

Cor e Forma: White to yellow powder or crystals

Peso molecular: 357.80

Ref: 7W-GP6163

Indomethacin-d4(chlorobenzoyl-d4)

CAS: 53-86-1, 87377-08-0

Pureza: 98 atom % D

Cor e Forma: White Solid

Peso molecular: 361.82

Ref: 3U-D6352

Indometacin

CAS: 53-86-1

Cor e Forma: Neat

Ref: 61-FOR0584.00

Indometacin 1.0 mg/ml in Acetonitrile

CAS: 53-86-1

Cor e Forma: Single Solution

Ref: 61-AMP0584.00-11

2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Pureza: 98.0%

Cor e Forma: Solid

Peso molecular: 357.79

Ref: 10-F358171

Indometacin

Produto Controlado

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Cor e Forma: Neat

Peso molecular: 357.79

Ref: 86-MM0584.00

Indomethacine

Produto Controlado

CAS: 53-86-1

Fórmula: C₁₉H₁₆ClNO₄

Cor e Forma: Neat

Peso molecular: 357.79

Ref: 04-C14325000

Indomethacin

Produto Controlado

CAS: 53-86-1

Impurity Acemetacin EP Impurity B
Applications Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Salari, H., et al.: Prostagland. Leukotrienes Med., 13, 53 (1984), Lehmann, J.M., et al.: J. Biol. Chem., 272, 3406 (1997)

Fórmula: C₁₉H₁₆ClNO₄

Cor e Forma: Neat

Peso molecular: 357.79

Ref: TR-I641000

Indometacin RS

CAS: 53-86-1

Cor e Forma: White To Pale Reddish Yellow Solid Crystals To Powder

Ref: 2K-101900002