CAS 55-03-8

Levotiroxina sódica

Descrição:

Levotiroxina sódica, com o número CAS 55-03-8, é uma forma sintética do hormônio tireoidiano tiroxina (T4) usada principalmente no tratamento do hipotireoidismo. É um pó cristalino branco a off-white que é solúvel em água e tem uma fórmula molecular de C15H11I4NNaO4. A substância atua aumentando a taxa metabólica dos tecidos, influenciando a síntese de proteínas e regulando o metabolismo de carboidratos e gorduras. Levotiroxina sódica é tipicamente administrado por via oral e é caracterizado por sua alta biodisponibilidade e longa meia-vida, permitindo a dosagem uma vez ao dia na maioria dos casos. É essencial para manter o crescimento e desenvolvimento normais, particularmente em crianças, e desempenha um papel crítico no metabolismo energético. A potência do medicamento pode ser afetada por vários fatores, incluindo a presença de alimentos, outros medicamentos e características individuais do paciente. Assim como com qualquer medicamento, o monitoramento dos níveis de hormônios tireoidianos é crucial para garantir a eficácia terapêutica e evitar possíveis efeitos colaterais associados ao tratamento excessivo ou insuficiente.

Fórmula: C₁₅H₁₁I₄NO₄·Na

InChI: InChI=1S/C15H11I4NO4.Na/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;/h1-2,4-5,12,21H,3,20H2,(H,22,23);/t12-;/m0./s1

Chave InChI: InChIKey=BRLSOHUOWVCKNI-YDALLXLXSA-N

SMILES: O(C1=CC(I)=C(O)C(I)=C1)C2=C(I)C=C(C[C@@H](C(O)=O)N)C=C2I.[Na]

Sinónimos:

• <span class="text-smallcaps">L</span>-Thyroxin Henning
• <span class="text-smallcaps">L</span>-Thyroxine monosodium salt
• <span class="text-smallcaps">L</span>-Thyroxine sodium
• <span class="text-smallcaps">L</span>-Thyroxine sodium salt
• <span class="text-smallcaps">L</span>-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt
• <span class="text-smallcaps">L</span>-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)
• Berlthyrox
• Dathroid
• Droxine
• Eferox
• Elthyrone
• Elthyroxine
• Eltroxin
• Euthyrox
• Eutirox
• L-Thyroxine sodium
• L-Thyroxine sodium salt
• Laevoxin
• Letrox
• Letter
• Levaxin
• Leventa
• Levo-T
• Levolet
• Levoroxine
• Levothroid
• Levothyrox
• Levotirox
• Levotiroxina
• Levoxyl
• Monosodium thyroxine
• NSC 259940
• Novothyrox
• Oroxine
• Puran T 4
• Sodium 2-Amino-3-[4-(4-Hydroxy-3,5-Diiodophenoxy)-3,5-Diiodophenyl]Propanoate
• Sodium 4-O-(4-Hydroxy-3,5-Diiodophenyl)-3,5-Diiodo-L-Tyrosine
• Sodium <span class="text-smallcaps">L</span>-thyroxine
• Sodium levothyroxine
• Sodium thyroxin
• Sodium thyroxinate
• Sodium thyroxine
• Synthroid
• Synthroid sodium
• Synthrox
• T 4Kp
• T4 Montpellier 100
• Thevier
• Throxinique
• Thyradin
• Thyradin S
• Thyrax Duotab
• Thyrex
• Thyro 4
• Thyrosit
• Thyroxevan
• Thyroxine sodium
• Thyroxine sodium salt
• Thyroxine, monosodium salt, <span class="text-smallcaps">L</span>-
• Tiroidine
• Tirosint
• Unithroid
• tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)
• L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodium salt
• L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1)

L-Thyroxine Sodium Salt Pentahydrate

CAS: 51-48-9, 55-03-8, 6106-07-6

Fórmula: C₁₅H₁₀I₄NNaO₄·5H₂O

Pureza: >98.0%(T)

Cor e Forma: White to Yellow to Orange powder to crystal

Peso molecular: 888.94

Ref: 3B-T0245

Levothyroxine sodium impurity standard

CAS: 55-03-8

Levothyroxine sodium impurity standard

Cor e Forma: White To Off-White

Ref: 47-1284

L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, monosodiumsalt

CAS: 55-03-8

Fórmula: C₁₅H₁₀I₄NNaO₄

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 798.8518

Ref: IN-DA00I9TF

L-Thyroxine sodium

CAS: 55-03-8

L-Thyroxine sodium

Pureza: ≥98%

Peso molecular: 798.85g/mol

Ref: 54-BUP18449

L-Thyroxine sodium

CAS: 55-03-8

L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.

Fórmula: C₁₅H₁₀I₄NO₄·Na

Pureza: 98.74%

Cor e Forma: Yellowish To Buff-Colored Amorphous Powder Solid

Peso molecular: 798.85

Ref: TM-T22355

Thyroxine Sodium Salt

Produto Controlado

CAS: 55-03-8

Stability Hygroscopic
Applications One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976), Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988), Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996), Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997),

Fórmula: C₁₅H₁₀I₄NO₄·Na

Cor e Forma: Neat

Peso molecular: 798.85

Ref: TR-T425601

Levothyroxine sodium

CAS: 55-03-8

Levothyroxine sodium is a thyroid hormone that is used to treat hypothyroidism. It is also used to treat goiter and other thyroid problems. Levothyroxine sodium comes in three different forms: tablets, oral solution, and levothyroxine sodium for injection. The tablet form of levothyroxine sodium is taken by mouth once daily with or without food. Oral solution is taken by mouth twice daily (morning and evening) with or without food. Injection should be given as directed by a physician or healthcare provider. Levothyroxine sodium can interact with many drugs, especially ones that affect the heart or blood sugar levels, such as potassium supplements, diuretics, beta blockers, calcium channel blockers, erythromycin, clarithromycin and ketoconazole. Levothyroxine sodium can also interact with certain foods such as soybean flour and grapefruit juice. Levothyroxine sodium has been shown to have a linear calibration curve in vivo

Fórmula: C₁₅H₁₀I₄NNaO₄

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 798.85 g/mol

Ref: 3D-FL32108