CAS 59865-13-3
:Ciclosporina A
Descrição:
Ciclosporina A é um polipeptídeo cíclico composto por 11 aminoácidos, conhecido principalmente por suas propriedades imunossupressoras. É produzido pelo fungo Tolypocladium inflatum e é amplamente utilizado em ambientes clínicos, particularmente em transplantes de órgãos e doenças autoimunes, para prevenir a rejeição de órgãos e gerenciar condições como artrite reumatoide. A substância funciona inibindo a ativação de linfócitos T, reduzindo assim a resposta imunológica. Ciclosporina A é lipofílico, o que afeta sua absorção e distribuição no corpo; geralmente é administrado por via oral ou intravenosa. Sua farmacocinética pode ser influenciada por vários fatores, incluindo a ingestão de alimentos e medicamentos concomitantes, exigindo monitoramento cuidadoso dos níveis sanguíneos para evitar toxicidade. Efeitos adversos podem incluir nefrotoxicidade, hipertensão e maior suscetibilidade a infecções. Devido às suas interações complexas e efeitos colaterais, Ciclosporina A requer gerenciamento cuidadoso e ajustes de dosagem com base na resposta individual do paciente e no contexto clínico.
Fórmula:C62H111N11O12
InChI:InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
Sinónimos:- Cyclosporina
- Cyclosporine
- Cyclosporin
- Restasis
- cyclosporin A
- Antibiotic S 7481F1
- 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
- (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
- 1: PN: US6686454 SEQID: 1 claimed protein
- 7: PN: WO0002548 PAGE: 30 claimed protein
- Arpimune ME
- Cicloral
- Cicloral (antibiotic)
- Ciclosporin
- Cipol N
- Consupren
- Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
- Debio088
- Equoral
- Gengraf
- Neoplanta
- Neoral
- Nsc 290193
- Ol 27-400
- Papilock Mini
- Ramihyphin A
- Sandimmun
- Sandimmune
- Sandimmune Neoral
- Sang-35
- SangCyA
- Sdz-Oxl 400
- Sigmasporin Microoral
- S-Neoral
- Zinograf ME
- Ver mais sinónimos
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26 produtos.
Cyclosporin A
CAS:Fórmula:C62H111N11O12Pureza:>97.0%(HPLC)(N)Cor e Forma:White to Almost white powder to crystalPeso molecular:1,202.64Cyclosporin A, 99+%
CAS:<p>Cyclosporin A, 59865-13-3, or cyclosporine, is a cyclic polypeptide which acts as a calcineurin inhibitor and immunosuppressive agent. Learn more at Thermo Fisher Scientific.</p>Fórmula:C62H111N11O12Pureza:99+%Cor e Forma:White, Powder or crystals or crystalline powderPeso molecular:1202.61CICLOSPORIN FOR SYSTEM SUITABILITY A CRS
CAS:<p>CICLOSPORIN FOR SYSTEM SUITABILITY A CRS</p>Cor e Forma:AddedCyclosporine
CAS:Lactams, nesoiFórmula:C62H111N11O12Cor e Forma:White PowderPeso molecular:1201.84137Ref: IN-DA00IKI7
1g40,00€5g91,00€1kgA consultar25g237,00€100gA consultar250gA consultar500gA consultar100mg24,00€250mg26,00€Cyclosporin A
CAS:<p>Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.</p>Fórmula:C62H111N11O12Pureza:99.00% - 99.92%Cor e Forma:White PowderPeso molecular:1202.61Cyclosporin A (Cyclosporine)
CAS:Fórmula:C62H111N11O12Cor e Forma:White To Off-White SolidPeso molecular:1202.64Cyclosporine A from Beauveria Nivea
CAS:<p>Cyclosporine A from Beauveria Nivea</p>Pureza:99%Cor e Forma:White SolidPeso molecular:1,202.61g/molCyclosporin A
CAS:Fórmula:C62H111N11O12Pureza:98.5 - 101.5 % (dried basis)Cor e Forma:Colourless crystals, or white to almost white powderPeso molecular:1202.61Ciclosporin
CAS:Produto ControladoFórmula:C62H111N11O12Cor e Forma:White To Off-WhitePeso molecular:1202.61Cyclosporin A from Tolypocladium inflatum
CAS:<p>Cyclosporin A from Tolypocladium inflatum</p>Fórmula:C62H111N11O12Pureza:By hplc: >99% (Typical Value in Batch COA)Cor e Forma: white solidPeso molecular:1,202.61g/molCyclosporin A, USP grade
CAS:Fórmula:C62H111N11O12Pureza:≤ 0.7%Cor e Forma:Colourless crystals, or white to almost white powderPeso molecular:1202.61Cyclosporin A
CAS:<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C62H111N11O12Cor e Forma:NeatPeso molecular:1202.61Cyclosporin A-d4 (Major)
CAS:Produto Controlado<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C62H107D4N11O12Cor e Forma:NeatPeso molecular:1206.66Cyclosporin A-13C2,d4 (Major)
CAS:Produto Controlado<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C2C60D4H107N11O12Cor e Forma:NeatPeso molecular:1208.62Cyclosporin A
CAS:<p>Binds cyclophilin D and inhibits calcineurin; immunosuppressant</p>Fórmula:C62H111N11O12Pureza:Min. 98.5 Area-%Cor e Forma:White PowderPeso molecular:1,202.61 g/molCyclosporin A - Bio-X ™
CAS:<p>Cyclosporin A (CsA) is a cyclic undecapeptide that is extracted from the fungus Tolypocladium inflatum. CsA is used as an immunosuppressive drug to prevent rejection of transplanted organs and to treat autoimmune diseases such as rheumatoid arthritis and psoriasis. CsA works by binding to a protein called cyclophilin D, which is a component of the enzyme calcineurin. Calcineurin is an important enzyme involved in the activation of immune cells, and by binding to cyclophilin D, CsA inhibits its activity. This leads to the inhibition of T-cell activation and the suppression of the immune response. Cyclosporin A has has been rpeorted to exhibit some nephrotoxicity, hypertension and also increases the risk of infections and tumors when used in transplantation</p>Fórmula:C62H111N11O12Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:1,202.61 g/molEverolimus, Cyclosporine and Tacrolimus Mix Standard
CAS:Produto ControladoFórmula:MixtureVisitourWebsiteCor e Forma:MixturePeso molecular:Mixture - Visit our Website
