CAS 59865-13-3

Ciclosporina A

Descrição:

Ciclosporina A é um polipeptídeo cíclico composto por 11 aminoácidos, conhecido principalmente por suas propriedades imunossupressoras. É produzido pelo fungo Tolypocladium inflatum e é amplamente utilizado em ambientes clínicos, particularmente em transplantes de órgãos e doenças autoimunes, para prevenir a rejeição de órgãos e gerenciar condições como artrite reumatoide. A substância funciona inibindo a ativação de linfócitos T, reduzindo assim a resposta imunológica. Ciclosporina A é lipofílico, o que afeta sua absorção e distribuição no corpo; geralmente é administrado por via oral ou intravenosa. Sua farmacocinética pode ser influenciada por vários fatores, incluindo a ingestão de alimentos e medicamentos concomitantes, exigindo monitoramento cuidadoso dos níveis sanguíneos para evitar toxicidade. Efeitos adversos podem incluir nefrotoxicidade, hipertensão e maior suscetibilidade a infecções. Devido às suas interações complexas e efeitos colaterais, Ciclosporina A requer gerenciamento cuidadoso e ajustes de dosagem com base na resposta individual do paciente e no contexto clínico.

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

Sinónimos:

• Cyclosporina
• Cyclosporine
• Cyclosporin
• Restasis
• cyclosporin A
• Antibiotic S 7481F1
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 1: PN: US6686454 SEQID: 1 claimed protein
• 7: PN: WO0002548 PAGE: 30 claimed protein
• Arpimune ME
• Cicloral
• Cicloral (antibiotic)
• Ciclosporin
• Cipol N
• Consupren
• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• Debio088
• Equoral
• Gengraf
• Neoplanta
• Neoral
• Nsc 290193
• Ol 27-400
• Papilock Mini
• Ramihyphin A
• Sandimmun
• Sandimmune
• Sandimmune Neoral
• Sang-35
• SangCyA
• Sdz-Oxl 400
• Sigmasporin Microoral
• S-Neoral
• Zinograf ME

Cyclosporin A

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Cor e Forma: Neat

Peso molecular: 1202.61

Ref: TR-C988900

Cyclosporin A-d4 (Major)

Produto Controlado

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₆₂H₁₀₇D₄N₁₁O₁₂

Cor e Forma: Neat

Peso molecular: 1206.66

Ref: TR-C988902

Cyclosporin A-13C2,d4 (Major)

Produto Controlado

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Fórmula: C₂C₆₀D₄H₁₀₇N₁₁O₁₂

Cor e Forma: Neat

Peso molecular: 1208.62

Ref: TR-C988901

Cyclosporin A

CAS: 59865-13-3

Binds cyclophilin D and inhibits calcineurin; immunosuppressant

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: Min. 98.5 Area-%

Cor e Forma: White Powder

Peso molecular: 1,202.61 g/mol

Ref: 3D-FC20749

Cyclosporin A - Bio-X ™

CAS: 59865-13-3

Cyclosporin A (CsA) is a cyclic undecapeptide that is extracted from the fungus Tolypocladium inflatum. CsA is used as an immunosuppressive drug to prevent rejection of transplanted organs and to treat autoimmune diseases such as rheumatoid arthritis and psoriasis. CsA works by binding to a protein called cyclophilin D, which is a component of the enzyme calcineurin. Calcineurin is an important enzyme involved in the activation of immune cells, and by binding to cyclophilin D, CsA inhibits its activity. This leads to the inhibition of T-cell activation and the suppression of the immune response. Cyclosporin A has has been rpeorted to exhibit some nephrotoxicity, hypertension and also increases the risk of infections and tumors when used in transplantation

Fórmula: C₆₂H₁₁₁N₁₁O₁₂

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 1,202.61 g/mol

Ref: 3D-BC164336

Everolimus, Cyclosporine and Tacrolimus Mix Standard

Produto Controlado

CAS: 104987-11-3, 159351-69-6, 59865-13-3

Fórmula: MixtureVisitourWebsite

Cor e Forma: Mixture

Peso molecular: Mixture - Visit our Website

Ref: TR-E608165