CAS 61825-94-3

Oxitiplatina

Descrição:

Oxitiplatina é um medicamento de quimioterapia à base de platina usado principalmente no tratamento do câncer colorretal. É classificado como um composto de platina de terceira geração e é conhecido por sua capacidade de formar ligações cruzadas de DNA, que inibem a replicação e transcrição do DNA, levando, em última instância, à morte das células cancerosas. Quimicamente, Oxitiplatina é um complexo de platina de diaminociclohexano, que aumenta sua eficácia e reduz a probabilidade de resistência em comparação com medicamentos de platina anteriores, como cisplatina e carboplatina. Geralmente é administrado por via intravenosa e muitas vezes é usado em combinação com outros agentes quimioterápicos. Oxitiplatina é caracterizado por sua solubilidade moderada em água e sua estabilidade em condições fisiológicas, embora possa sofrer hidrólise na presença de água, levando à formação de espécies reativas. Os efeitos colaterais comuns incluem neuropatia periférica, náuseas e mielossupressão. Seu mecanismo de ação único e perfil de efeitos colaterais o tornam uma opção valiosa no arsenal terapêutico oncológico, particularmente para pacientes com câncer colorretal avançado ou metastático.

Fórmula: C₈H₁₄N₂O₄Pt

InChI: InChI=1/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1/rC8H14N2O4Pt/c11-7-8(12)14-15(13-7)9-5-3-1-2-4-6(5)10-15/h5-6H,1-4,9-10H2/t5-,6-/m1/s1

Chave InChI: InChIKey=ZROHGHOFXNOHSO-BNTLRKBRSA-L

SMILES: O=C1[O-][Pt+2]2([NH2][C@]3([C@]([NH2]2)(CCCC3)[H])[H])[O-]C1=O

Sinónimos:

• Oxalato(trans-(-)-1,2-cyclohexanediamine)platinum(II)
• Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-
• platinum(2+) ethanedioate (1R,2R)-cyclohexane-1,2-diamine (1:1)
• NSC-266046
• [SP-4-2-(IR-trans)]-(1,2-cyclohexanediamine-n,n')[ethanedioato(2-)-O,O']-platinum
• (1R,2R)-cyclohexane-1,2-diamine: oxalic acid: platinum(+2) cation
• xalatoplatinum
• (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]platinum
• Platinum, [(1R,2R)-1,2-cyclohexanediamine-κN,κN′][ethanedioato(2-)-κO1,κO2]-, (SP-4-2)-
• latin
• cyclohexane-1,2-diamine: oxalic acid: platinum
• RP-54780
• (sp-4-2)-((1r,2r)-1,2-cyclohexanediamine-n,n')(ethanedioato(2-)-O,O']platinum
• Platinum, (1,2-cyclohexanediamine-N,N′)[ethanedioato(2-)-O,O′]-, [SP-4-2-(1R-trans)]-
• platinum(4+) cyclohexane-1,2-diyldiazanide ethanedioate (1:1:1)
• Elocatin
• Oxalipatin
• trans-L-Diaminocyclohexane oxalatoplatinum
• 1,2-Cyclohexanediamine, platinum complex, (1R-trans)-
• ι-OHP
• [SP-4-2-(1R-trans)]-(1，2-Cyclohexanediamine-N，N，)[ethanedioato(2-)-O，O’Jplatinum
• OXALIPLATIN
• OXALIPIATIN
• Lipoxal
• SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N)[ETHANEDIOATO(2-)-O,OPT
• Oxaliplatin(Eloxatin)
• NSC-266046：Elocatin
• Eloxatin
• Cis-[(1R,2R)-1,2-cyclothexanediammine-N,N`][oxalato(2-)-O,O`]platinum
• Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
• P-54780
• oxalatoplatinum
• [SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM
• oxaliplatino
• Oxaliplatin (125 mg)
• platinuM(2+) ion (1R,2R)-cyclohexane-1,2-diaMine oxalate
• oxalatoplatin
• Oxaliplatin EP/BP
• (1R-trans)-1,2-Cyclohexanediamine, platinum complex
• [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N
• 1-ohp
• (1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr
• OxaliplatinEp5
• Dacplat
• Elplat
• OXALIPLATIN (oxaliplatin)
• oxalato(1r,2r-cyclohexanediammine)platinum(ii)
• [SP-4-2-（1R-trans）]-(1,2-Cyclohexanediamine-N,Nˊ)[ethanedioato(2-)-O,Oˊ]platinum
• (trans-1,2-Cyclohexanediamine)oxalatoplatinum(II)
• Oxaliplatin99%
• Oxaliplatin API

Oxaliplatin

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 397.29

Ref: 3B-O0372

OXALIPLATIN CRS

CAS: 61825-94-3

OXALIPLATIN CRS

Fórmula: C₈H₁₂N₂O₄Pt

Peso molecular: 395.2759

Ref: 41-Y0000271

Oxaliplatin

CAS: 61825-94-3

Inorganic or organic compounds of precious metals, whether or not chemically defined, or amalgams of precious metals, nesoi

Fórmula: C₈H₁₄N₂O₄Pt

Cor e Forma: White Off-White Powder

Peso molecular: 397.06015

Ref: 45-1481204

Trans-L-Diaminocyclohexane Oxalatoplatinum

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 397.2858

Ref: IN-DA0035Q1

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis.

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: 97% - 99.93%

Cor e Forma: White Solid

Peso molecular: 397.29

Ref: TM-T0164

Oxaliplatin

CAS: 61825-94-3

Oxalato(trans-l-1,2-cyclohexanediamine)platinum(II)

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: 98%

Peso molecular: 397.29

Ref: IN-DG146411

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: ≥95%

Peso molecular: 397.29

Ref: 54-BUP16056

Oxaliplatin

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Cor e Forma: White To Off-White Solid

Peso molecular: 397.29

Ref: 4Z-O-242

Oxaliplatin

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: 98.0 - 102.0 % (dried basis)

Cor e Forma: White to almost white crystalline powder

Peso molecular: 397.29

Ref: 7W-GP0792

Oxaliplatin, EP grade

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Peso molecular: 397.29

Ref: 7W-GP9874

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 397.28575

Ref: 54-BISN0119

Oxaliplatin

Produto Controlado

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Cor e Forma: Neat

Peso molecular: 397.29

Ref: 86-MM0921.00

Oxaliplatin

CAS: 61825-94-3

Fórmula: C₈H₁₄N₂O₄Pt

Peso molecular: 397.29

Ref: ST-EA-CP-O12000

Oxaliplatin

Produto Controlado

CAS: 61825-94-3

Applications Third generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
References Kidani, Y., et al.: J. Med. Chem., 21, 1315 (1978), Kizu, R., et al.: Cancer Chemother. Pharmacol., 31, 475 (1993), Levi, F., et al.: Eur. J. Cancer, 29A, 1280 (1993), Simpson, D., et al.: Drugs, 63, 2127 (2003),

Fórmula: C₈H₁₄N₂O₄Pt

Cor e Forma: Neat

Peso molecular: 397.29

Ref: TR-O845075

Oxaliplatin

CAS: 61825-94-3

Oxaliplatin is a platinum-based DNA-cross-linking agent. It is a chemotherapeutic drug, often used in combination with leucovorin, fluorouracil, and capecitabine. Oxaliplatin works by cross-linking DNA thus inhibiting the synthesis of RNA and proteins, which leads to cell death and inhibition of cancer cells growth. It is more effective than cisplatin or irinotecan in treating metastatic cancer. Oxaliplatin also has effects on Toll-like receptor 4 (TLR4) expression levels in vitro and in vivo models. In addition, oxaliplatin's effect on ATP binding cassette transporter proteins may be responsible for its antitumour activity against solid tumours.

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: Min. 98 Area-%

Cor e Forma: White Off-White Powder

Peso molecular: 397.29 g/mol

Ref: 3D-FD26607

Oxaliplatin - Bio-X ™

CAS: 61825-94-3

Oxaliplatin is a platinum-based DNA-cross-linking agent. It is a chemotherapeutic drug, often used in combination with leucovorin, fluorouracil, and capecitabine. Oxaliplatin works by cross-linking DNA thus inhibiting the synthesis of RNA and proteins, which leads to cell death and inhibition of cancer cells growth. It is more effective than cisplatin or irinotecan in treating metastatic cancer. Oxaliplatin also has effects on Toll-like receptor 4 (TLR4) expression levels in vitro and in vivo models. In addition, oxaliplatin's effect on ATP binding cassette transporter proteins may be responsible for its antitumour activity against solid tumours.
Oxaliplatin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₈H₁₄N₂O₄Pt

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 397.29 g/mol

Ref: 3D-BO164182

Oxaliplatin

CAS: 61825-94-3

Pureza: 98%

Peso molecular: 397.06

Ref: 10-F556520

Oxaliplatin RS

CAS: 61825-94-3

Cor e Forma: White Solid Crystalline Powder

Ref: 2K-1032100021