CAS 63968-64-9

Artemisinina

Descrição:

Artemisinina é uma lactona sesquiterpênica com a fórmula química C15H22O5, derivada principalmente da planta de absinto doce, Artemisia annua. É conhecida por suas potentes propriedades antimaláricas e é um componente chave nas terapias combinadas baseadas em Artemisinina (ACT) usadas para tratar a malária. O composto apresenta uma ponte endoperóxido única, que é crucial para sua atividade biológica. Artemisinina exibe solubilidade moderada em solventes orgânicos como etanol e clorofórmio, mas tem solubilidade limitada em água. Seu mecanismo de ação envolve a geração de espécies reativas de oxigênio após ativação pelo heme, levando à destruição dos parasitas da malária. Artemisinina é geralmente bem tolerado, embora possa causar efeitos colaterais como náuseas e tontura em alguns pacientes. Devido à sua origem natural e eficácia, a pesquisa continua na otimização de seus derivados e na melhoria de suas propriedades farmacológicas. Além disso, estudos em andamento estão explorando suas potenciais aplicações além da malária, incluindo seus efeitos em vários tipos de câncer e outras doenças.

Fórmula: C₁₅H₂₂O₅

InChI: InChI=1/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14+,15-/m1/s1

Chave InChI: InChIKey=BLUAFEHZUWYNDE-NNWCWBAJSA-N

SMILES: C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(OC1=O)[H])[H]

Sinónimos:

• (+)-Arteannuin
• (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• (3S,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• (5aS,6R,8aS,9R,12S)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,12S,12aR)-
• 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, [3R-(3α,5aβ,6β,8aβ,9α,12β,12aR*)]-
• 3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
• ARTIVeda
• Artemef
• Artemisine
• Artemisinine
• Hc 101A
• Huanghuahaosu
• NSC 369397
• PulmoHeal
• Qing Hau Sau
• Qing Hau Su
• Qinghaosu
• Qinghosu
• [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one
• Artemisinin
• Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one
• ARTEANUIN
• (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12ar*)-(+)-methyl
• Artemisinin Qinghaosu/ [3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one
• ARTEMISININ (QINGHAOSU)
• SWEET WORMWOOD
• artemisiaannual.,extract
• ARTEMETHER
• 3,12-epoxy-12h-pyranol(4,3-j)-1,2-benzodioxepin-10(3h)-one,octahydro-3,6,9-tri
• ArteMisinin, 98%, froM ArteMisia annua L.
• qinghausau
• ARTEMISININ 99%
• 3,13-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)one,(ctahydro-3,6,9-trimethyl-,[3R-(3α,5αβ,6β,8αβ,9α,12β,12αR*)]-
• Arteannuin99%
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epox12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• Artemisinine,98%
• QHS
• Astemisinin
• Arteannuin, Qinghaosu
• ARTEMISIA P E
• QINGHAOSA
• octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10(
• ALPHA BETA ARTEMISININ
• Quinghaosu
• qinghausu
• ArteMisinin, froM ArteMisia annua
• 3,12-Epoxy-12H-pyranol(4,3-j)-1,2-benzodioxepin-10(3H)-one, octahydro-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR*)-(+)
• (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3 ,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• ARTEMISIA ANNUA
• Artemisine，Artemisinin，Arteannuin
• Artemisia annual L Ext.

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Pureza: >97.0%(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 282.34

Ref: 3B-A2118

Artemisinin, 98%

CAS: 63968-64-9

Artemisinin inhibits angiogenesis by down-regulating HIF-1 and VEGF expression in mouse embryonic stem cells. Artemisinin crosses the blood-brain barrier and is an inhibitor of human NOS2 (iNOS). This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio.

Fórmula: C₁₅H₂₂O₅

Pureza: 98%

Cor e Forma: Crystals or crystalline powder, White

Peso molecular: 282.34

Ref: 02-J65406

ARTEMISININ RS

CAS: 63968-64-9

ARTEMISININ RS

Fórmula: C₁₅H₂₂O₅

Cor e Forma: Powder

Peso molecular: 282.3322

Ref: 41-ICRS43857

Artemisinin

CAS: 63968-64-9

Heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Fórmula: C₁₅H₂₂O₅

Cor e Forma: White Off-White Solid

Peso molecular: 282.14672

Ref: 45-1042747

(1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-one

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 282.3322

Ref: IN-DA00IBB0

Artemisinin

CAS: 63968-64-9

Artemisinin (Qinghaosu) is a natural sesquiterpene lactone. Artemisinin has anti-malarial, neuroprotective and anti-tumor effects. Cost-effective and quality-assured.

Fórmula: C₁₅H₂₂O₅

Pureza: 99.77% - 99.87%

Cor e Forma: Crystalline Solid

Peso molecular: 282.33

Ref: TM-T0392

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White to off-white crystalline powder

Peso molecular: 282.33

Ref: 7W-GP0718

Artemisinin

CAS: 63968-64-9

Artemisinin

Pureza: ≥95%

Peso molecular: 282.33g/mol

Ref: 54-BUP16845

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Peso molecular: 282.34

Ref: 4Z-A-309

Artemisinin

CAS: 63968-64-9

Cor e Forma: Neat

Ref: 86-MM0803.00

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Pureza: 95%~99%

Peso molecular: 282.336

Ref: BP-BP0197

Artemisinin

CAS: 63968-64-9

Artemisinin

Fórmula: C₁₅H₂₂O₅

Pureza: 97%

Cor e Forma: white crystalline needles

Peso molecular: 282.33g/mol

Ref: 54-BIA4320

Artemisinin

CAS: 63968-64-9

Lactone

Fórmula: C₁₅H₂₂O₅

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 282.34

Ref: 5G-89484

Artemisinin

CAS: 63968-64-9

Artemisinin is a sesquiterpene lactone, which is derived from the plant Artemisia annua, commonly known as sweet wormwood. This compound is isolated through a series of extraction and purification processes from the plant's leaves and flowers. Artemisinin exerts its pharmacological effect through a novel mode of action that involves endoperoxide bridges, which interact with intracellular iron to generate free radicals. These reactive species subsequently damage vital biomolecules within Plasmodium parasites, effectively inhibiting their ability to thrive and reproduce.

Fórmula: C₁₅H₂₂O₅

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 282.33 g/mol

Ref: 3D-FA09640

Artemisinin-d4

Produto Controlado

CAS: 63968-64-9

Fórmula: C₁₅D₄H₁₈O₅

Cor e Forma: Neat

Peso molecular: 286.357

Ref: TR-A777503

Artemisinin-13C-D3

Produto Controlado

CAS: 63968-64-9

Fórmula: CC₁₄D₃H₁₉O₅

Cor e Forma: Neat

Peso molecular: 286.343

Ref: TR-A777504

Artesunate IP Impurity B

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Peso molecular: 282.34

Ref: ST-EA-CP-A93012

Artemisinin

CAS: 63968-64-9

Fórmula: C₁₅H₂₂O₅

Cor e Forma: White to Off-White Solid

Peso molecular: 282.33

Ref: TR-A777500