CAS 65473-14-5
:Cloridrato de naftifina
Descrição:
Cloridrato de naftifina é um agente antifúngico usado principalmente no tratamento de infecções por dermatófitos, como pé de atleta e micose. Pertence à classe das aliilaminas e funciona inibindo a enzima esqualeno epoxidase, que é crucial na biossíntese de ergosterol, um componente essencial das membranas celulares fúngicas. Essa interrupção leva ao acúmulo de esqualeno tóxico e, em última análise, resulta na morte celular fúngica. Cloridrato de naftifina é tipicamente administrado topicamente, permitindo um tratamento localizado com mínima absorção sistêmica. O composto é caracterizado por sua forma de pó cristalino branco a off-white, com solubilidade relativamente baixa em água, mas melhor solubilidade em solventes orgânicos. Sua farmacocinética indica uma duração de ação prolongada, tornando-o eficaz com aplicações uma vez ao dia. Os perfis de segurança indicam que geralmente é bem tolerado, com poucos efeitos colaterais, embora a irritação local possa ocorrer em alguns pacientes. No geral, Cloridrato de naftifina é uma opção valiosa na terapia antifúngica, particularmente para infecções superficiais da pele.
Fórmula:C21H21N·ClH
InChI:InChI=1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
Chave InChI:InChIKey=OLUNPKFOFGZHRT-YGCVIUNWSA-N
SMILES:C(N(C/C=C/C1=CC=CC=C1)C)C=2C3=C(C=CC2)C=CC=C3.Cl
Sinónimos:- (E)-N-Cinnamyl-N-methyl(1-naphthylmethyl)amine hydrochloride
- (E)-N-Cirmamyl-N-mcthyl(1一naphthylmethyl)amine hydrochloridc
- 1-Naphthalenemethanamine, N-methyl-N-(3-phenyl-2-propenyl)-, hydrochloride, (E)-
- 1-Naphthalenemethanamine, N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:1)
- 1-Naphthalenemethanamine, N-methyl-N-[(2E)-3-phenyl-2-propenyl]-, hydrochloride
- Aw 105-843
- Exoderil
- Naftifine HCl
- Naftin
- Sn 105-843
- Naftifine hydrochloride
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Foram encontrados 17 produtos.
Naftifine Hydrochloride
CAS:Aromatic monoamines not elsewhere specified or included and their derivatives, salts therofFórmula:C21H21N·HClCor e Forma:White PowderPeso molecular:287.1674Naftifine hydrochloride
CAS:Naftifine HCl: synthetic antifungal; inhibits squalene epoxidase, disrupting fungal cell sterol synthesis.Fórmula:C21H22ClNPureza:98.87% - 99.84%Cor e Forma:SolidPeso molecular:323.86Naftifine hydrochloride
CAS:Naftifine hydrochlorideFórmula:C21H22ClNPureza:99%Cor e Forma:SolidPeso molecular:323.86Naftifine-d3 HCl
CAS:Fórmula:C21H18D3N·HClCor e Forma:White To Off-White SolidPeso molecular:290.42 36.46Naftifine Hydrochloride
CAS:Fórmula:C21H21N·HClPureza:>98.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:323.86Naftifine hydrochloride (Standard)
CAS:Naftifine hydrochloride (Standard) is the standard substance of Naftifine hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2, 3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride (Naftifine HCl) can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved.Fórmula:C21H22ClNCor e Forma:SolidPeso molecular:323.86Naftifine hydrochloride
CAS:Fórmula:C21H21N·HClPureza:99.0 - 101.0 %Cor e Forma:White to off-white powderPeso molecular:323.86Naftifine HCl
CAS:(E)-N-Methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine hydrochlorideFórmula:C21H22ClNPureza:98%Peso molecular:323.86Naftifine Hydrochloride
CAS:Produto ControladoApplications Antimycotic allylamine. An antifungal (topical) agent.
References Georgopoulos, A., et al.: Antimicrob. Ag. Chemother., 19, 386 (1981), Meingassner, J.C., et al.: J. Invest. Dermatol., 77, 444 (1981), Paltauf, F., et al.: Biochim Biophys. Acta, 712, 268 (1982), Aggarwal, D., et al.: J. Pharm. Pharmacol., 56, 1509 (2004),Fórmula:C21H21N·ClHCor e Forma:NeatPeso molecular:323.86(E)-N-Methyl-N-(3-phenyl-2-propen-1-yl)-1-naphthalenemethanamine hydrochloride
CAS:Naphthalene-1,3-diamine is an antifungal drug that belongs to a class of phenylenediamines. It is active against some bacteria and yeasts, including Candida albicans and Aspergillus niger. Naphthalene-1,3-diamine has been shown to have in vitro activity against mycological pathogens, such as Trichophyton mentagrophytes and Microsporum canis. The drug binds to the enzyme epoxidase in the fungal cell membrane. This binding inhibits the conversion of ergosterol to ergosta-4,6-diene which leads to increased membrane permeability and leakage of cytoplasmic contents. Naphthalene-1,3-diamine also inhibits human polymorphonuclear leukocytes (PMNL) chemotaxis by blocking phosphatidylserine externalization on PMNL membranes. In vitro studies showFórmula:C21H22ClNPureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:323.86 g/mol
