CAS 693222-51-4

Fórmula: C15H13N5O2

InChI: InChI=1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,22H,5-6H2,(H,17,21)(H3,16,19,20)

Chave InChI: RZEPRPGFGRQXDI-UHFFFAOYSA-N

SMILES: C1CNC(=O)C2=NC3=CC=CC=C3C2=C1C4=C(N=C(N4)N)O

Hymenialdisine Analogue #1

Produto Controlado

CAS: 693222-51-4

Applications The indole derivative of Hymenialdisine, a potent inhibitor of a variety of kinases including MEK-1, GSK-3Β, and CKI. It also exhibits inhibition of the G2 cell cycle checkpoint at the micromolar concentrations. This compound exhibits very potent inhibition of Chk2 activity in the low nanomolar range (IC50=8nM). Exhibits an increased selectivity for the checkpoint kinases over natural Hymenialdisine.
References Sharma, V., and Tepe, J.J.: Bioorg. & Medicinal Chem. Letters, 14, 4319 (2004), Sharma, V., et al.: J. Med. Chem., 47, 3700 (2004)

Fórmula: C₁₅H₁₃N₅O₂

Cor e Forma: Neat

Peso molecular: 295.3

Ref: TR-H998025

Hymenialdisine Analogue #1

CAS: 693222-51-4

Hymenialdisine Analogue #1: Indole-derived kinase inhibitor (MEK-1, GSK-3Β, CKI), disrupts G2 cell cycle checkpoint.

Fórmula: C₁₅H₁₃N₅O₂

Cor e Forma: Solid

Peso molecular: 295.3

Ref: TM-T68855