CAS 7177-50-6

Nafcilina sódica monoidratada

Descrição:

Nafcilina sódica monoidratada é um antibiótico penicilínico semissintético, utilizado principalmente para tratar infecções causadas por estafilococos produtores de penicilinase. É caracterizado por sua capacidade de resistir à degradação por certas beta-lactamases, tornando-o eficaz contra cepas bacterianas específicas. O composto aparece como um pó cristalino branco a off-white e é solúvel em água, o que facilita sua administração por injeção. Sua estrutura molecular inclui um anel beta-lactâmico, um anel de tiazolidina e um íon de sódio, contribuindo para suas propriedades antibacterianas. Nafcilina sódica monoidratada é tipicamente administrado por via intravenosa ou intramuscular, e sua farmacocinética envolve rápida distribuição nos tecidos do corpo, com uma meia-vida relativamente curta. Os efeitos colaterais comuns podem incluir reações alérgicas, distúrbios gastrointestinais e potencial nefrotoxicidade. Assim como outros antibióticos, é essencial usar Nafcilina sódica monoidratada de forma judiciosa para prevenir o desenvolvimento de resistência a antibióticos. No geral, continua sendo uma opção crítica no tratamento de certas infecções bacterianas, particularmente aquelas causadas por cepas resistentes.

Fórmula: C₂₁H₂₃N₂NaO₆S

InChI: InChI=1/C21H22N2O5S.Na.H2O/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23;;/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27);;1H2/q;+1;/p-1/t15-,16+,19-;;/m1../s1

Chave InChI: InChIKey=RKBDQTFFBRQMPN-KMFBOIRUSA-N

SMILES: C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(=O)C=3C4=C(C=CC3OCC)C=CC=C4)C2=O)(SC1(C)C)[H].[Na].O

Sinónimos:

• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2-ethoxy-1-naphthalenyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S-(2alpha,5alpha,6beta))
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, hydrate (1:1:1), (2S,5R,6R)-
• Monosodium (2S,5R,6R)-6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate monohydrate
• Nafcil
• Nafcillin natrium-1-wasser
• Nafcillin sodium salt monohydrate
• Sodium 6-(2-ethoxy-1-naphthamido)penicillanate monohydrate
• Sodium nafcillin monohydrate
• Unii-49G3001Bck
• Wy 3277
• sodium (2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
• Nafcillin monohydrate sodium salt
• NAFCILLINSODIUMSTERILE
• Sodium (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
• nafcillin sodium

Nafcillin Sodium

CAS: 7177-50-6

Penicillins and their derivatives with a penicillanic acid structure and salts thereof, nesoi

Fórmula: C₂₁H₂₁N₂NaO₅S·H₂O

Cor e Forma: White Light Yellow Crystalline Powder

Peso molecular: 454.11745

Ref: 45-1450007

Nafcillin sodium monohydrate

CAS: 7177-50-6

Nafcillin sodium monohydrate (CL 8491) is a semi-synthetic naphthalene, nafcillin inhibits bacterial wall synthesis by a mechanism similar to penicillin.

Fórmula: C₂₁H₂₁N₂O₅SNa·H₂O

Pureza: 96.62%

Cor e Forma: White Powder

Peso molecular: 454.47

Ref: TM-T1312

(2S,5R,6R)-6-[[(2-Ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium hydrate

CAS: 7177-50-6

Fórmula: C₂₁H₂₃N₂NaO₆S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 454.4719

Ref: IN-DA0062G3

Nafcillin sodium monohydrate

CAS: 7177-50-6

Nafcillin sodium monohydrate

Pureza: ≥90%

Peso molecular: 454.47g/mol

Ref: 54-BUP15832

Nafcillin sodium salt monohydrate

CAS: 7177-50-6

Nafcillin sodium salt monohydrate

Pureza: 98%(Contain 2-3% ethyl acetate)

Peso molecular: 454.47g/mol

Ref: 54-OR1028266

Nafcillin sodium monohydrate 100 µg/mL in Acetonitrile

CAS: 7177-50-6

Fórmula: C₂₁H₂₁N₂O₅S·Na·H₂O

Cor e Forma: Single Solution

Peso molecular: 454.47

Ref: 04-A15402500AL-100

Nafcillin sodium salt monohydrate

CAS: 7177-50-6

Fórmula: C₂₁H₂₁N₂O₅SNa·H₂O

Pureza: ≥ 98.5% (anhydrous basis)

Cor e Forma: White to yellow crystalline powder or crystals

Peso molecular: 454.47

Ref: 7W-GA3972

Sodium Nafcillin Monohydrate

CAS: 7177-50-6

Applications Sodium Nafcillin Monohydrate is used as an antibiotic, used in the treatment, used in the treatment of gram-positive bacteria.
References Taboada, P. et al.: Langmuir. 16, 3175 (2000);

Fórmula: C₂₁H₂₁N₂O₅S·Na·H₂O

Cor e Forma: Off-White

Peso molecular: 454.47

Ref: TR-S645800

Nafcilllin sodium monohydrate

CAS: 7177-50-6

Nafcillin sodium monohydrate is a beta-lactam antibiotic, which is derived from the penicillin class of antimicrobials. It is specifically a semi-synthetic penicillin and is commonly sourced through chemical synthesis to enhance its stability and spectrum of activity. Nafcillin primarily exerts its bactericidal effects by inhibiting bacterial cell wall synthesis. It achieves this through its strong affinity for penicillin-binding proteins (PBPs), which are essential for maintaining the bacterial cell wall structure. By disrupting the formation of peptidoglycan cross-links, nafcillin effectively weakens the bacterial cell wall, leading to cell lysis and death, especially in gram-positive bacteria such as Staphylococcus aureus, including methicillin-sensitive strains (MSSA).

Fórmula: C₂₁H₂₁N₂O₅SNa·H₂O

Pureza: Min. 95%

Cor e Forma: White to off-white solid.

Peso molecular: 454.47 g/mol

Ref: 3D-AN61452

Nafcillin Sodium hydrate

CAS: 7177-50-6

Fórmula: C₂₁H₂₂N₂O₅SNaH₂O

Peso molecular: 414.5 : 23.0 : 18.0

Ref: ST-EA-CP-N68001