CAS 71827-03-7

Ivermectina B1a

Descrição:

Ivermectina B1a, com o número CAS 71827-03-7, é uma lactona macrocíclica derivada da fermentação da bactéria do solo Streptomyces avermitilis. É um potente agente antiparasitário utilizado principalmente na medicina veterinária e tem aplicações na medicina humana para tratar várias infecções parasitárias. Ivermectina B1a exibe um amplo espectro de atividade contra nematoides e ectoparasitas, incluindo piolhos e sarna. O composto funciona ligando-se aos canais de cloro ativados por glutamato, levando a um aumento da permeabilidade da membrana celular aos íons de cloro, resultando em paralisia e morte dos parasitas. A ivermectina é geralmente bem tolerada, com um perfil de segurança favorável, embora possa causar efeitos colaterais em alguns indivíduos, particularmente em doses mais altas. A substância é tipicamente administrada por via oral ou tópica, dependendo do tipo de infecção que está sendo tratada. Sua eficácia e segurança a tornaram um componente crítico nas iniciativas de saúde global, particularmente no combate a doenças tropicais negligenciadas.

Fórmula: C₄₈H₇₄O₁₄

InChI: InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1

Chave InChI: InChIKey=AZSNMRSAGSSBNP-XPNPUAGNSA-N

SMILES: O[C@]/12[C@@]3(OC\C1=C/C=C/[C@H](C)[C@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(\C)=C\C[C@@]6(C[C@](OC(=O)[C@@]2(C=C(C)[C@H]3O)[H])(C[C@]7(O6)O[C@]([C@H](CC)C)([C@@H](C)CC7)[H])[H])[H])[H]

Sinónimos:

• (2aE,4E,5'S,6S,6'R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl (4xi)-2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-threo-hexopyranoside
• 22,23-Dihydro-5-O-demethylavermectin A1a
• 22,23-Dihydroavermectin B(1)a
• 22,23-Dihydroavermectin B1a
• 22,23-Dihydroavermectin B_1a
• 5-O-Demethyl-22,23-dihydroavermectin A_1a
• Avermectin A1a, 22,23-dihydro-5-O-demethyl-
• Avermectin A_1a, 5-O-demethyl-22,23-dihydro-
• Brn 4643153
• Dihydroavermectin B1a
• Dihydroavermectin B_1a
• Ivermectin B1a
• Ivermectin B_1a
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], avermectin A_1a deriv.
• Unii-91Y2202Ouw
• Avermectin A1a, 5-O-demethyl-22,23-dihydro-
• 5-O-Demethyl-22,23-dihydroavermectin A1a

Ivermectin B1a-d2

CAS: 71827-03-7

Fórmula: C₄₈H₇₂D₂O₁₄

Cor e Forma: White To Off-White Solid

Peso molecular: 877.12

Ref: 4Z-I-077008

Ivermectin B1a

CAS: 71827-03-7

Ivermectin B1a

Pureza: ≥98%

Peso molecular: 875.09g/mol

Ref: 54-BUP00618

Ivermectin B1a

CAS: 71827-03-7

Fórmula: C₄₈H₇₄O₁₄

Cor e Forma: White To Off-White Solid

Peso molecular: 875.11

Ref: 4Z-I-077016

Ivermectine B1a

CAS: 71827-03-7

Cor e Forma: Neat

Ref: 04-CA14488005

Ivermectin B1a

CAS: 71827-03-7

Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.

Fórmula: C₄₈H₇₄O₁₄

Pureza: ≥98%

Cor e Forma: Solid

Peso molecular: 875.09

Ref: TM-T21727

Ivermectin B1a-D2

Produto Controlado

CAS: 71827-03-7

Applications Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

Fórmula: C₄₈H₇₂D₂O₁₄

Cor e Forma: Neat

Peso molecular: 877.11

Ref: TR-I940817

Ivermectin B1a (>85%)

Produto Controlado

CAS: 71827-03-7

Applications Ivermectin B1a is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

Fórmula: C₄₈H₇₄O₁₄

Pureza: >85%

Cor e Forma: Neat

Peso molecular: 875.09

Ref: TR-I940815

Ivermectin B1a-D2

CAS: 71827-03-7

Ivermectin is a broad-spectrum antiparasitic agent that is used to treat onchocerciasis and other infectious diseases. It binds selectively to gamma-aminobutyric acid (GABA) receptors in the central nervous system and inhibits the release of neurotransmitters, thereby inhibiting the inflammatory response. Ivermectin has been shown to be safe for use in humans and has a long half-life that allows for once-weekly administration. This drug also has pharmacokinetic properties that are similar among different species and clinical studies have shown no significant differences between human and animal models. Ivermectin is applied topically as an ointment or cream or orally as tablets or capsules, depending on the condition being treated.

Fórmula: C₄₈H₇₂D₂O₁₄

Pureza: Min. 95%

Peso molecular: 877.11 g/mol

Ref: 3D-WCA82703

Ivermectin 2-epimer

CAS: 71827-03-7

Fórmula: C₄₈H₇₄O₁₄

Peso molecular: 875.11

Ref: ST-EA-CP-I18017