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CAS 71827-03-7

:

Ivermectina B1a

Descrição:
Ivermectina B1a, com o número CAS 71827-03-7, é uma lactona macrocíclica derivada da fermentação da bactéria do solo Streptomyces avermitilis. É um potente agente antiparasitário utilizado principalmente na medicina veterinária e tem aplicações na medicina humana para tratar várias infecções parasitárias. Ivermectina B1a exibe um amplo espectro de atividade contra nematoides e ectoparasitas, incluindo piolhos e sarna. O composto funciona ligando-se aos canais de cloro ativados por glutamato, levando a um aumento da permeabilidade da membrana celular aos íons de cloro, resultando em paralisia e morte dos parasitas. A ivermectina é geralmente bem tolerada, com um perfil de segurança favorável, embora possa causar efeitos colaterais em alguns indivíduos, particularmente em doses mais altas. A substância é tipicamente administrada por via oral ou tópica, dependendo do tipo de infecção que está sendo tratada. Sua eficácia e segurança a tornaram um componente crítico nas iniciativas de saúde global, particularmente no combate a doenças tropicais negligenciadas.
Fórmula:C48H74O14
InChI:InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
Chave InChI:InChIKey=AZSNMRSAGSSBNP-XPNPUAGNSA-N
SMILES:O[C@]/12[C@@]3(OC\C1=C/C=C/[C@H](C)[C@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(\C)=C\C[C@@]6(C[C@](OC(=O)[C@@]2(C=C(C)[C@H]3O)[H])(C[C@]7(O6)O[C@]([C@H](CC)C)([C@@H](C)CC7)[H])[H])[H])[H]
Sinónimos:
  • (2aE,4E,5'S,6S,6'R,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl (4xi)-2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-threo-hexopyranoside
  • 22,23-Dihydro-5-O-demethylavermectin A1a
  • 22,23-Dihydroavermectin B(1)a
  • 22,23-Dihydroavermectin B1a
  • 22,23-Dihydroavermectin B<sub>1a</sub>
  • 5-O-Demethyl-22,23-dihydroavermectin A<sub>1a</sub>
  • Avermectin A1a, 22,23-dihydro-5-O-demethyl-
  • Avermectin A<sub>1a</sub>, 5-O-demethyl-22,23-dihydro-
  • Brn 4643153
  • Dihydroavermectin B1a
  • Ver mais sinónimos
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Foram encontrados 12 produtos.
  • Ivermectin B1a

    CAS:
    Ivermectin B1a
    Fórmula:C48H74O14
    Pureza:≥95%
    Peso molecular:875.09

    Ref: 54-BUP00618

    1mg
    73,00€
    5mg
    181,00€
    10mg
    263,00€
    25mg
    509,00€
    50mg
    746,00€
  • Ref: IN-DA00FBJ9

    1mg
    64,00€
    5mg
    142,00€
    10mg
    172,00€
    25mg
    293,00€
    50mg
    657,00€
    100mg
    742,00€
  • Ivermectin B1a-d2

    CAS:
    Fórmula:C48H72D2O14
    Cor e Forma:White To Off-White Solid
    Peso molecular:877.12

    Ref: 4Z-I-077008

    5mg
    A consultar
    100mg
    A consultar
    10mg
    1.429,00€
    25mg
    2.620,00€
    50mg
    4.108,00€
  • Ivermectin B1a

    CAS:
    Fórmula:C48H74O14
    Cor e Forma:White To Off-White Solid
    Peso molecular:875.11

    Ref: 4Z-I-077016

    5mg
    A consultar
    100mg
    A consultar
    10mg
    436,00€
    25mg
    623,00€
    50mg
    810,00€
  • Ivermectine B1a

    CAS:
    Cor e Forma:Neat

    Ref: 04-CA14488005

    10mg
    416,00€
  • Ivermectin B1a

    CAS:
    Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.
    Fórmula:C48H74O14
    Pureza:96.18% - ≥98%
    Cor e Forma:White Solid
    Peso molecular:875.09

    Ref: TM-T21727

    1mg
    50,00€
    5mg
    114,00€
    10mg
    177,00€
    1mL*10mM (DMSO)
    215,00€
    25mg
    356,00€
    50mg
    522,00€
  • Ivermectin B1a-D2

    Produto Controlado
    CAS:

    Applications Ivermectin B1a-D2 is a deuterium labelled analogue of Ivermectin B1a (I940815), which is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
    References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

    Fórmula:C48H72D2O14
    Cor e Forma:Neat
    Peso molecular:877.11

    Ref: TR-I940817

    1mg
    223,00€
    5mg
    807,00€
    10mg
    1.601,00€
  • Ivermectin B1a (>85%)

    Produto Controlado
    CAS:

    Applications Ivermectin B1a is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.
    Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
    References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178

    Fórmula:C48H74O14
    Pureza:>85%
    Cor e Forma:Neat
    Peso molecular:875.09

    Ref: TR-I940815

    5mg
    135,00€
    10mg
    352,00€
    25mg
    609,00€
  • Ref: BE-RMCI144015

    1mg
    254,00€
  • Ivermectin B1a-D2

    CAS:
    Ivermectin is a broad-spectrum antiparasitic agent that is used to treat onchocerciasis and other infectious diseases. It binds selectively to gamma-aminobutyric acid (GABA) receptors in the central nervous system and inhibits the release of neurotransmitters, thereby inhibiting the inflammatory response. Ivermectin has been shown to be safe for use in humans and has a long half-life that allows for once-weekly administration. This drug also has pharmacokinetic properties that are similar among different species and clinical studies have shown no significant differences between human and animal models. Ivermectin is applied topically as an ointment or cream or orally as tablets or capsules, depending on the condition being treated.
    Fórmula:C48H72D2O14
    Pureza:Min. 95%
    Peso molecular:877.11 g/mol

    Ref: 3D-WCA82703

    10mg
    879,00€
    25mg
    1.459,00€
  • Ivermectin 2-epimer

    CAS:
    Fórmula:C48H74O14
    Peso molecular:875.11

    Ref: ST-EA-CP-I18017

    10mg
    A consultar
    25mg
    A consultar
    50mg
    A consultar
    100mg
    A consultar