CAS 73030-71-4

Atractilenolídeo III

Descrição:

Atractilenolídeo III é um composto bioativo derivado principalmente das raízes da erva medicinal chinesa tradicional Atractylodes macrocephala. Pertence à classe dos sesquiterpenos e é caracterizado por sua estrutura química única, que contribui para suas várias propriedades farmacológicas. Este composto é conhecido por seus potenciais efeitos anti-inflamatórios, anticancerígenos e imunomoduladores, tornando-o de interesse tanto na medicina tradicional quanto na pesquisa farmacológica moderna. Atractilenolídeo III exibe uma gama de atividades biológicas, incluindo a capacidade de inibir certas enzimas e modular vias de sinalização, o que pode contribuir para seus efeitos terapêuticos. Além disso, foi estudado por seus efeitos protetores contra o estresse oxidativo e seu papel em melhorar as respostas imunológicas. O composto é tipicamente extraído e purificado para fins de pesquisa, e seu perfil de segurança é geralmente considerado favorável, embora mais estudos sejam necessários para entender completamente seus mecanismos de ação e aplicações potenciais em ambientes clínicos.

Fórmula: C₁₅H₂₀O₃

InChI: InChI=1/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1

Chave InChI: InChIKey=FBMORZZOJSDNRQ-GLQYFDAESA-N

SMILES: O[C@@]12C(C[C@@]3([C@@](C)(C1)CCCC3=C)[H])=C(C)C(=O)O2

Sinónimos:

• (4aS,8aR,9aS)-4a,5,6,7,8,8a,9,9a-Octahydro-9a-hydroxy-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
• (4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one
• 8β-Hydroxyasterolide
• Atractylenolide III
• Atractylenolide β
• Codonolactone
• Naphtho(2,3-b)furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, (4aS,8aR,9aS)-
• Naphtho[2,3-b]furan-2(4H)-one, 4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-, [4aS-(4aα,8aβ,9aβ)]-
• Atractylenolide III, BR
• (4aS,8aR,9aS)-9a-Hydroxy-3,8a-dimethyl-5-methylidene-4,4a,6,7,8,9-hexahydrobenzo[f][1]benzoxol-2-one
• Atractylenolide beta
• 8-HYDROXYASTEROLIDE
• ICodonolactone
• Atracylenolide III
• ATRACTYLENOLIDE
• (4aS)-4a,5,6,7,8,8a,9,9a-Octahydro-9aβ-hydroxy-3,8aβ-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
• Atractylenolide III (ICodonolactone
• Atractylenolide III USP/EP/BP

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III

Fórmula: C₁₅H₂₀O₃

Pureza: ≥98%

Peso molecular: 248.32

Ref: 54-BUP10043

Atractylenolide III

CAS: 73030-71-4

Fórmula: C₁₅H₂₀O₃

Peso molecular: 248.32

Ref: 7W-GL2829

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III is the major bioactive component of Atractylodes lancea, it inhibits histamine release, suppresses activation of p38 mitogen-activated protein kinase, C-Jun-N-terminal protein kinase, and nuclear factor-κB in stimulated HMC-1 cells, and suppresses the activation of caspase-1 and the expression of receptor interacting protein-2, suggests that atractylenolide III may control immunological reactions by regulating the cellular functions of IL-6 in mast cells.

Fórmula: C₁₅H₂₀O₃

Pureza: 95%~99%

Cor e Forma: White cryst.

Peso molecular: 248.322

Ref: BP-BP0216

Atractylenolide III

CAS: 73030-71-4

Fórmula: C₁₅H₂₀O₃

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 248.32

Ref: 3B-A3609

Atractylenolide III

CAS: 73030-71-4

(4aS,8aR,9aS)-9a-Hydroxy-3,8a-dimethyl-5-methylene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one

Fórmula: C₁₅H₂₀O₃

Pureza: 98%

Peso molecular: 248.32

Ref: IN-DG34761

Atractylenolide III

CAS: 73030-71-4

Atractylenolide III could treat cognitive issues and lung cancer by modulating apoptosis factors.

Fórmula: C₁₅H₂₀O₃

Pureza: 99.53% - 99.98%

Cor e Forma: Solid

Peso molecular: 248.32

Ref: TM-T3902

Atractylenolide III

CAS: 73030-71-4

Lactone

Fórmula: C₁₅H₂₀O₃

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 248.32

Ref: 5G-80359

ATRACTYLENOLIDE III

CAS: 73030-71-4

Pureza: 98%

Peso molecular: 248.3220062

Ref: 10-F809712

AtractylenolideIII

CAS: 73030-71-4

Atractylenolide III is a sesquiterpene lactone, which is derived from the rhizomes of Atractylodes macrocephala, a plant commonly used in traditional Chinese medicine. With its origin in botanical sources, the compound is notable for its diverse biological activities and mechanisms of action. Atractylenolide III exerts its effects primarily through the modulation of various signaling pathways, including anti-inflammatory, anti-cancer, and immunomodulatory pathways. It inhibits the production of pro-inflammatory cytokines and regulates the expression of key signaling proteins, thus impacting cellular processes such as proliferation, apoptosis, and differentiation. The compound shows promise in the treatment of conditions like cancer, inflammation, and immune disorders. Researchers continue to explore its potential benefits, seeking to elucidate the molecular mechanisms underlying its therapeutic effects and to optimize its application in various biomedical fields.

Pureza: Min. 95%

Ref: 3D-FA73865

Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a,9,9a-octahydro-9a-hydroxy-3,8a-dimethyl-5-methylene-,(4aS,8aR,9aS)-

CAS: 73030-71-4

Fórmula: C₁₅H₂₀O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 248.3175

Ref: IN-DA00ICC9