CAS 778274-97-8

Fórmula: C20H17F3N4O3

InChI: InChI=1S/C20H17F3N4O3/c21-20(22,23)30-16-7-5-15(6-8-16)27-18-11-17(25-12-26-18)13-1-3-14(4-2-13)19(29)24-9-10-28/h1-8,11-12,28H,9-10H2,(H,24,29)(H,25,26,27)

Chave InChI: DEGDCVFNFAOIPU-UHFFFAOYSA-N

SMILES: C1=CC(=CC=C1C2=CC(=NC=N2)NC3=CC=C(C=C3)OC(F)(F)F)C(=O)NCCO

Multi-kinase inhibitor 1

CAS: 778274-97-8

Multi-kinase inhibitor 1

Fórmula: C₂₀H₁₇F₃N₄O₃

Pureza: 99.5%

Peso molecular: 418.37

Ref: 54-BUP04993

N-(2-Hydroxyethyl)-4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide

CAS: 778274-97-8

Fórmula: C₂₀H₁₇F₃N₄O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 418.3692

Ref: IN-DA00GA5O

Multi-kinase inhibitor 1

CAS: 778274-97-8

Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.

Fórmula: C₂₀H₁₇F₃N₄O₃

Pureza: 99.87%

Cor e Forma: Solid

Peso molecular: 418.3692

Ref: TM-T4191

MDK74978

CAS: 778274-97-8

MDK74978 is a small molecule that binds to the ATP-binding site of the HIF-1α kinase and inhibits its activity. It has been shown to inhibit the activity of other multi-kinase enzymes, such as PKCθ, Akt, and ERK1/2. MDK74978 has shown efficacy in animal models for treatment of iron overload disorders, such as hereditary hemochromatosis (HFE) and thalassemia major (HBA). In these models, MDK74978 improved iron homeostasis by increasing hepcidin synthesis in hepatocytes. This drug also showed efficacy in a mouse model with chronic kidney disease (CKD), which may be due to its ability to regulate erythropoietin production and enhance erythropoiesis.

Fórmula: C₂₀H₁₇F₃N₄O₃

Pureza: Min. 95%

Peso molecular: 418.38 g/mol

Ref: 3D-DGB27497