CAS 78832-65-2

N-(3-(2-furil)acrilol)-L-leucil-glicil-L-prolil-L-alanina

Descrição:

N-(3-(2-furil)acrilol)-L-leucil-glicil-L-prolil-L-alanina, com o número CAS 78832-65-2, é um derivado de peptídeo sintético que incorpora tanto sequências de aminoácidos quanto um moiety baseado em furanos. Este composto apresenta uma estrutura única que combina as propriedades de um peptídeo com as de um acrilamida, o que pode conferir reatividade específica e atividade biológica. A presença do anel de furanos sugere potencial para interações com sistemas biológicos, possivelmente influenciando suas propriedades farmacológicas. Os componentes de aminoácidos—L-leucina, glicina, L-prolina e L-alanina—contribuem para a estabilidade e solubilidade do composto, ao mesmo tempo que afetam suas características conformacionais. Esses peptídeos podem exibir várias atividades biológicas, incluindo efeitos antimicrobianos, anticancerígenos ou inibitórios de enzimas, dependendo de sua estrutura e das interações específicas em que se envolvem. No geral, este composto representa uma interseção fascinante da química orgânica e da bioquímica, com aplicações potenciais no desenvolvimento de medicamentos e na pesquisa terapêutica.

Fórmula: C₂₃H₃₂N₄O₇

InChI: InChI=1/C23H32N4O7/c1-14(2)12-17(26-19(28)9-8-16-6-5-11-34-16)21(30)24-13-20(29)27-10-4-7-18(27)22(31)25-15(3)23(32)33/h5-6,8-9,11,14-15,17-18H,4,7,10,12-13H2,1-3H3,(H,24,30)(H,25,31)(H,26,28)(H,32,33)/b9-8+/t15-,17-,18-/m0/s1

Chave InChI: ZLFQNOJSYZSINX-PVJKAEHXSA-N

SMILES: C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)/C=C/C2=CC=CO2

Sinónimos:

• N-(3-(2-furyl)acryloyl)-leu-gly-pro-ala
• FA-Leu-Gly-Pro-Ala-OH
• Falgpa
• N-[(2E)-3-furan-2-ylprop-2-enoyl]-L-leucylglycyl-L-prolyl-L-alanine
• COLLAGENASE CELL PREPARATION GRADE
• COLLAGENASE GRADE II
• COLLAGENASE GRADE I
• clostridiopeptidase
• CollagenaseⅡ
• N-[3-(2-FURYL)ACRYLOYL]-L-LEUCYL-GLYCYL-L-PROLYL-L-ALANINE
• (2S)-3-{2-[(1E)-2-{[(1S)-1-({2-[(2S)-2-{[(1S)-1-carboxyethyl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl}carbamoyl)-3-methylbutyl]carbamoyl}eth-1-en-1-yl]-1λ3-furan-1-yl}-2-{[(2S)-1-{2-[(2S)-2-[(2E)-3-(furan-2-yl)prop-2-enamido]-4-methylpentanamido]acetyl}pyrro
• N-[3-(2-furyl)acryloyl]-leucine-glycine-proline-alanine
• N-(3-(2-FURYL)ACRYLOYL)-L-LEUCYL-GLYCYL&
• N-{3-(2-Furyl)acryloyl}-L-leucine-glycyl-L-propyl-L-alanine
• FALGPA, N-[3-(2-Furyl)acryloyl]-L-leucyl-glycyl-L-prolyl-L-alanine
• COLLAGENASE SUBSTRATE II
• COLLAGENASE HIGHLY PURIFIED
• CollagenaseⅠ
• CollagenaseⅤ
• CollagenaseⅣ
• 2-furanacryloyl-leucyl-glycyl-prolyl-alanine
• COLLAGENASE (CLOSTRIDIOPEPTIDASE A)

FA-Leu-Gly-Pro-Ala-OH

CAS: 78832-65-2

Substrate for a versatile, convenient, continuously recording spectrophotometric assay of collagenase.

Fórmula: C₂₃H₃₂N₄O₇

Pureza: 97.7%

Cor e Forma: Beige

Peso molecular: 476.53

Ref: 01-4006713

FALGPA

CAS: 78832-65-2

FALGPA

Fórmula: C₂₃H₃₂N₄O₇

Pureza: By hplc: >98% by area (Typical Value in Batch COA)

Cor e Forma: White Solid-Powder

Peso molecular: 476.52277

Ref: 54-BIF0744

FA-Leu-Gly-Pro-Ala-O

CAS: 78832-65-2

FA-Leu-Gly-Pro-Ala-OH is a synthetic peptide and a specific collagenase substrate, widely used in biochemical experiments and drug synthesis research.

Fórmula: C₂₃H₃₂N₄O₇

Pureza: 99.90%

Cor e Forma: Solid

Peso molecular: 476.52

Ref: TM-T205939

(3-(Furan-2-yl)acryloyl)-L-leucylglycyl-L-prolyl-L-alanine

CAS: 78832-65-2

Fórmula: C₂₃H₃₂N₄O₇

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 476.5228

Ref: IN-DA005DFG

FA-Leu-Gly-Pro-Ala-OH

CAS: 78832-65-2

(3-(Furan-2-yl)acryloyl)-L-leucylglycyl-L-prolyl-L-alanine

Fórmula: C₂₃H₃₂N₄O₇

Pureza: 98%

Peso molecular: 476.52

Ref: IN-DG129969

FA-Leu-Gly-Pro-Ala-OH

CAS: 78832-65-2

FA-Leu-Gly-Pro-Ala-OH is a gelatinase inhibitor that inhibits the action of collagenase, an enzyme that breaks down collagen. It has been shown to inhibit the growth of cancer cells in vitro and may be useful as a therapeutic agent against skin cancer. FA-Leu-Gly-Pro-Ala-OH binds to the active site of the enzyme and blocks its catalytic activity by preventing proton transfer during the hydrolysis of peptide bonds. This inhibitor also has proteolytic properties, which are due to its ability to cleave proteins with basic amino acids such as arginine and lysine. The inhibitory effects of FA-Leu-Gly-Pro-Ala-OH on histological analysis were also tested on fibroblast cells with collagenase activity, which showed a significant reduction in enzyme activity after incubation with this inhibitor.

Fórmula: C₂₃H₃₂N₄O₇

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 476.52 g/mol

Ref: 3D-FF110857