CAS 80279-24-9

(11S,11aS)-9-hidroxi-11-(1H-indol-3-il)-1,2,3,10,11,11a-hexahidro-5H-pirrolo[2,1-c][1,4]benzodiazepin-5-ona

Fórmula: C₂₀H₁₉N₃O₂

InChI: InChI=1/C20H19N3O2/c24-17-9-3-6-13-19(17)22-18(16-8-4-10-23(16)20(13)25)14-11-21-15-7-2-1-5-12(14)15/h1-3,5-7,9,11,16,18,21-22,24H,4,8,10H2/t16-,18-/m0/s1

Chave InChI: AJZNARCWDDMOPL-WMZOPIPTSA-N

SMILES: c1ccc2c(c1)c(c[nH]2)[C@H]1[C@@H]2CCCN2C(=O)c2cccc(c2N1)O

Tilivalline

CAS: 80279-24-9

Tilivalline

Fórmula: C₂₀H₁₉N₃O₂

Pureza: ≥97%

Peso molecular: 333.38

Ref: 54-OR1110424

Tilivalline

CAS: 80279-24-9

Applications Tilivalline, is a metabolite from Klebsiella oxytoca. Tilivalline, is shown to be cytotoxin, and the key event causing Antibiotic-Associated Hemorrhagic Colitis.
References Mori, Sh., et al.: Tetrahedron, 47, No.27, 5051 (1991); Nagasaka, T., et al.: Tetrahedron Lett., 14, 1871 (1989);

Fórmula: C₂₀H₁₉N₃O₂

Cor e Forma: Neat

Peso molecular: 333.38

Ref: TR-T440350

Tilivalline

CAS: 80279-24-9

Tilivalline is a compound that belongs to the class of 3-hydroxyanthranilic acid synthase inhibitors. It prevents the synthesis of 3-hydroxyanthranilic acid by binding to the enzyme and inhibiting its activity. The stereoselective inhibitory effect of tilivalline on bacterial cells has been demonstrated using mammalian cells in culture. Tilivalline also inhibits cellular respiration, resulting in inhibition of fatty acid synthesis and production of chloride ions, which can lead to cell death due to hypotonic shock. Tilivalline has shown chemical diversity, with a variety of hydroxy groups including one at the 3-position, which may confer additional activity against microbial pathogens.

Fórmula: C₂₀H₁₉N₃O₂

Pureza: Min. 95%

Peso molecular: 333.4 g/mol

Ref: 3D-FDA27924