CAS 82586-52-5

Cloridrato de moexipril

Descrição:

Cloridrato de moexipril é um inibidor da enzima conversora de angiotensina (ECA) usado principalmente no tratamento da hipertensão. É um pró-fármaco que é convertido no corpo em sua forma ativa, moexiprilato, que exerce seus efeitos farmacológicos inibindo a conversão de angiotensina I em angiotensina II, levando à vasodilatação e à redução da pressão arterial. A fórmula química de Cloridrato de moexipril inclui uma estrutura complexa com um derivado de prolina, que contribui para sua eficácia e especificidade. Geralmente é administrado por via oral e é conhecido por sua meia-vida relativamente longa, permitindo a dosagem uma vez ao dia. Os efeitos colaterais comuns podem incluir tontura, tosse e níveis elevados de potássio, entre outros. Assim como outros inibidores da ECA, é contraindicado em pacientes com histórico de angioedema relacionado à terapia anterior com inibidores da ECA e deve ser usado com cautela em indivíduos com comprometimento renal. No geral, Cloridrato de moexipril é um agente terapêutico importante no manejo da saúde cardiovascular.

Fórmula: C₂₇H₃₄N₂O₇·ClH

InChI: InChI=1S/C27H34N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32);1H/t17-,21-,22-;/m0./s1

Chave InChI: InChIKey=JXRAXHBVZQZSIC-JKVLGAQCSA-N

SMILES: C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2CC=3C(C[C@H]2C(O)=O)=CC(OC)=C(OC)C3.Cl

Sinónimos:

• (3S)-2-[(2S)-2-{[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisochinolin-3-carbons?urehydrochlorid
• (3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
• (3S)-2-{N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
• (3S)-2-{N-[(2S)-1-Ethoxy-1-oxo-4-phenyl-2-butanyl]-L-alanyl}-6,7-dimethoxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride (1:1)
• (3S)-2-{N-[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride (1:1)
• (3S-(2(R*(R*)),3R*))-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-3-isoquinolinecarboxylic acid monohydrochloride
• 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (3S)-, hydrochloride (1:1)
• 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1), (3S)-
• 3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, monohydrochloride, (3S)-
• 3-Isoquinolinecarboxylic acid, 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, monohydrochloride, [3S-[2[R*(R*)],3R*]]-
• 3-isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (3S)-, monohydrochloride
• Ci 925
• Moexipril HCl
• Primox
• Rs 10085-197
• Spm 925
• Univasc

Moexipril Hydrochloride

CAS: 82586-52-5

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

Fórmula: C₂₇H₃₄N₂O₇·HCl

Cor e Forma: Powder

Peso molecular: 498.2366

Ref: 45-1445426

Moexipril hydrochloride

CAS: 82586-52-5

Fórmula: C₂₇H₃₅N₂O₇Cl

Pureza: ≥ 98.0%

Cor e Forma: Conflicting attributes defined

Peso molecular: 535.03

Ref: 7W-GP1850

Moexipril HCl

CAS: 82586-52-5

Fórmula: C₂₇H₃₄N₂O₇·HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 498.58 36.46

Ref: 4Z-M-311

Moexipril-d5 HCl

CAS: 1356929-49-1, 82586-52-5

Fórmula: C₂₇H₂₉D₅N₂O₇·HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 503.61 36.46

Ref: 4Z-M-312

Moexipril hydrochloride

CAS: 82586-52-5

Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of

Fórmula: C₂₇H₃₄N₂O₇·HCl

Pureza: 97.8%

Cor e Forma: A Fine White To Off-White Powder

Peso molecular: 535.03

Ref: TM-T6595

Moexipril Hydrochloride

Produto Controlado

CAS: 82586-52-5

Applications Angiotensin converting enzyme (ACE) inhibitor; dimethoxy analog of quinapril.
References Edling, O., et al.: J. Pharmacol. Exp. Ther., 275, 854 (1995), White, W.B., et al.: J. Hum. Hypertens., 8, 917 (1994), Stimpel, M., et al.: Cardiology 87, 313 (1996)

Fórmula: C₂₇H₃₄N₂O₇·ClH

Cor e Forma: Neat

Peso molecular: 535.03

Ref: TR-M485350

Moexipril HCl

CAS: 82586-52-5

Inhibitor of angiotensin converting enzyme

Fórmula: C₂₇H₃₅ClN₂O₇

Pureza: Min. 95%

Cor e Forma: Off-White Powder

Peso molecular: 535.03 g/mol

Ref: 3D-FM26040

Moexipril HCl - Bio-X ™

CAS: 82586-52-5

Moexipril is an angiotensin converting enzyme inhibitor that is used for the treatment of hypertension. This drug is a prodrug for moexiprilat and works by relaxing the blood vessels causing them to widen and lowering blood pressure. Moexipril has been shown to be effective in treating metabolic disorders such as congestive heart failure.

Fórmula: C₂₇H₃₄N₂O₇

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 498.57 g/mol

Ref: 3D-BM164604