CAS 83651-90-5

peptídeo relacionado ao gene da calcitonina

Descrição:

O peptídeo relacionado ao gene da calcitonina (CGRP) é um neuropeptídeo que desempenha um papel significativo em vários processos fisiológicos, particularmente no sistema nervoso e na regulação cardiovascular. É derivado do gene da calcitonina e é conhecido por seus potentes efeitos vasodilatadores, que contribuem para a regulação do fluxo sanguíneo e da pressão arterial. O CGRP é composto por 37 aminoácidos e é encontrado principalmente nos sistemas nervoso central e periférico. Está envolvido na transmissão da dor e foi implicado na fisiopatologia da enxaqueca, tornando-se um alvo para tratamentos de enxaqueca. Além disso, o CGRP tem papéis na inflamação e em processos neurogênicos. O peptídeo existe em duas isoformas, alfa e beta, que diferem ligeiramente em suas sequências de aminoácidos, mas compartilham funções biológicas semelhantes. Devido aos seus papéis diversos, o CGRP é de grande interesse na farmacologia, particularmente no desenvolvimento de terapias para enxaqueca e outras condições relacionadas à dor. Seu número CAS, 83651-90-5, é usado para identificação em bancos de dados químicos e contextos regulatórios.

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

InChI: InChI=1S/C162H262N50O52S2/c1-71(2)49-95(184-114(225)62-177-129(233)79(17)181-138(242)96(50-72(3)4)191-136(240)91(40-32-46-174-161(169)170)186-141(245)99(54-88-59-173-70-180-88)197-158(262)127(85(23)220)211-155(259)122(77(13)14)205-150(254)108-69-266-265-68-107(201-132(236)89(164)64-213)149(253)195-101(56-111(166)222)146(250)209-124(82(20)217)156(260)183-81(19)131(235)208-125(83(21)218)159(263)202-108)139(243)192-97(51-73(5)6)140(244)200-106(67-216)148(252)187-92(41-33-47-175-162(171)172)137(241)199-104(65-214)133(237)178-60-113(224)176-61-116(227)203-120(75(9)10)154(258)206-121(76(11)12)153(257)189-90(39-30-31-45-163)135(239)196-103(58-118(230)231)143(247)194-100(55-110(165)221)142(246)193-98(53-87-37-28-25-29-38-87)144(248)207-123(78(15)16)160(264)212-48-34-42-109(212)151(255)210-126(84(22)219)157(261)198-102(57-112(167)223)145(249)204-119(74(7)8)152(256)179-63-115(226)185-105(66-215)147(251)188-93(43-44-117(228)229)134(238)182-80(18)130(234)190-94(128(168)232)52-86-35-26-24-27-36-86/h24-29,35-38,59,70-85,89-109,119-127,213-220H,30-34,39-58,60-69,163-164H2,1-23H3,(H2,165,221)(H2,166,222)(H2,167,223)(H2,168,232)(H,173,180)(H,176,224)(H,177,233)(H,178,237)(H,179,256)(H,181,242)(H,182,238)(H,183,260)(H,184,225)(H,185,226)(H,186,245)(H,187,252)(H,188,251)(H,189,257)(H,190,234)(H,191,240)(H,192,243)(H,193,246)(H,194,247)(H,195,253)(H,196,239)(H,197,262)(H,198,261)(H,199,241)(H,200,244)(H,201,236)(H,202,263)(H,203,227)(H,204,249)(H,205,254)(H,206,258)(H,207,248)(H,208,235)(H,209,250)(H,210,255)(H,211,259)(H,228,229)(H,230,231)(H4,169,170,174)(H4,171,172,175)/t79-,80-,81-,82+,83+,84+,85+,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-,124-,125-,126-,127-/m0/s1

Chave InChI: SVAGNGUJZNLSEY-TYNJZYKVSA-N

SMILES: C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)[C@@H](C)O)CC(=O)N)NC(=O)[C@H](CO)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N)[C@@H](C)O

Sinónimos:

• .alpha.-CGRP (rat)
• H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bond)

α-CGRP (mouse, rat)

CAS: 83651-90-5

Induces elevation of cAMP and cGMP in rat aorta.

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Pureza: 96.8%

Cor e Forma: White

Peso molecular: 3806.3

Ref: 01-4025897

α-CGRP, rat

CAS: 83651-90-5

Endogenous neuropeptide, potent vasodilator

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 3806.25

Ref: TM-TP2233

β-Calcitonin Gene Related Peptide II (rat)

CAS: 83651-90-5

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Pureza: 98%

Peso molecular: 3806.2475

Ref: IN-DA01ENG0

CGRP (Rat)

CAS: 83651-90-5

CGRP (Rat) product with the disulfide Bonds: Cys2-Cys7 and available as a 0.1 mg vial. CGRP is the calcitonin gene-related peptide (CGRP), a neuropeptide that plays an important role in the regulation of vascular tone and blood flow, as well as pain perception, inflammation, and neurogenic inflammation. It is a potent vasodilator and has been implicated in a wide range of physiological and pathophysiological processes.
This product has the potential for use in the study of the physiological and pathological roles of CGRP and to investigate the effects of CGRP on blood vessels, neurons, and other tissues. It has also been used to develop models of migraine headaches and other conditions associated with CGRP dysfunction.

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Pureza: Min. 95%

Peso molecular: 3,806.2 g/mol

Ref: 3D-PCG-4163-S

α-CGRP (mouse, rat)

CAS: 83651-90-5

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist which is secreted in both peripheral and central neurons. It is a potent vasodilator and can function in the transmission of nociception as well as acting as an appetite suppressant and contributing to gastric acid secretion.  It also has a function in temperature homeostasis, increases heart rate, and can play a role in the release of the pituitary hormone.

Fórmula: C₁₆₂H₂₆₂N₅₀O₅₂S₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 3,806.25 g/mol

Ref: 3D-CRB1000889

CGRP (Rat)

CAS: 83651-90-5

CGRP (Rat) product with the disulfide Bonds: Cys2-Cys7 and available as a 0.5mg vial. CGRP is the calcitonin gene-related peptide (CGRP), a neuropeptide that plays an important role in the regulation of vascular tone and blood flow, as well as pain perception, inflammation, and neurogenic inflammation. It is a potent vasodilator and has been implicated in a wide range of physiological and pathophysiological processes.
This product has the potential for use in the study of the physiological and pathological roles of CGRP and to investigate the effects of CGRP on blood vessels, neurons, and other tissues. It has also been used to develop models of migraine headaches and other conditions associated with CGRP dysfunction.

Pureza: Min. 95%

Ref: 3D-PCG-4163-V