CAS 853909-77-0

Fórmula: C25H16ClN5

InChI: InChI=1S/C25H15N5.ClH/c26-12-11-18-5-8-21(9-6-18)30-17-29-24-16-28-23-10-7-19(14-22(23)25(24)30)3-4-20-2-1-13-27-15-20;/h1-2,5-10,13-17H,11H2;1H

Chave InChI: RUXNLVOZJZTQAS-UHFFFAOYSA-N

SMILES: C1=CC(=CN=C1)C#CC2=CC3=C4C(=CN=C3C=C2)N=CN4C5=CC=C(C=C5)CC#N.Cl

4-[8-[2-(3-Pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]benzeneacetonitrile

CAS: 853909-77-0

4-[8-[2-(3-Pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]benzeneacetonitrile (LSQA) is a sesquiterpene lactone that was originally isolated from the roots of Ligusticum scoticum. LSQA has been shown to have anticancer activity in vitro and in vivo against colorectal adenocarcinoma by inducing apoptosis through the mitochondrial membrane potential and by inhibiting the synthesis of DNA. The molecular docking analysis revealed hydrogen bonding interactions between LSQA and DNA polymerase β, which may be responsible for its inhibition of this enzyme.

Fórmula: C₂₅H₁₆ClN₅

Pureza: Min. 95%

Peso molecular: 421.9 g/mol

Ref: 3D-DJB90977

PDK1-IN-3

CAS: 853909-77-0

PDK1-IN-3 (Compound C) is a PDK1 inhibitor with an IC50 value of 34 nM.

Fórmula: C₂₅H₁₅N₅

Peso molecular: 385.42

Ref: TM-T201162