CAS 863031-21-4

Azilsartan medoxomil

Descrição:

Azilsartan medoxomil é um antagonista do receptor de angiotensina II usado principalmente no tratamento da hipertensão. É um pró-fármaco que é convertido no corpo em sua forma ativa, azilsartana, que bloqueia seletivamente o receptor tipo 1 da angiotensina II, levando à vasodilatação e à redução da pressão arterial. A fórmula química de Azilsartan medoxomil reflete sua estrutura complexa, que inclui um grupo bifenila e um grupo ácido carboxílico. Este composto é caracterizado por sua alta potência e longa duração de ação, tornando-o eficaz para dosagem uma vez ao dia. Azilsartan medoxomil é tipicamente administrado por via oral e é bem absorvido, com sua farmacocinética influenciada por fatores como a ingestão de alimentos. Efeitos colaterais comuns podem incluir tontura, fadiga e distúrbios gastrointestinais. Assim como outros agentes antihipertensivos, é importante monitorar a função renal e os níveis de eletrólitos durante o tratamento. No geral, Azilsartan medoxomil representa um avanço significativo no manejo da hipertensão, proporcionando uma opção eficaz para pacientes que necessitam de terapia antihipertensiva.

Fórmula: C₃₀H₂₄N₄O₈

InChI: InChI=1S/C30H24N4O8/c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)

Chave InChI: InChIKey=QJFSABGVXDWMIW-UHFFFAOYSA-N

SMILES: C(N1C=2C(N=C1OCC)=CC=CC2C(OCC=3OC(=O)OC3C)=O)C4=CC=C(C=C4)C5=C(C=CC=C5)C=6NC(=O)ON6

Sinónimos:

• (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-[[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate
• (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-(5-oxo-2H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
• 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
• Edarbi
• Ipreziv
• Tak 491
• Azilsartan medoxomil

(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate

CAS: 863031-21-4

(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 2-ethoxy-1-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate

Pureza: 95%

Peso molecular: 568.5419922

Ref: 10-F858802

(5-Methyl-2-Oxo-1,3-Dioxol-4-Yl)Methyl 2-Ethoxy-1-((2'-(5-Oxo-4,5-Dihydro-1,2,4-Oxadiazol-3-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-1H-Benzo[D]Imidazole-7-Carboxylate

CAS: 863031-21-4

(5-Methyl-2-Oxo-1,3-Dioxol-4-Yl)Methyl 2-Ethoxy-1-((2'-(5-Oxo-4,5-Dihydro-1,2,4-Oxadiazol-3-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-1H-Benzo[D]Imidazole-7-Carboxylate

Pureza: 98%

Peso molecular: 568.53g/mol

Ref: 54-OR1029032

Azilsartan Medoxomil

CAS: 863031-21-4

Fórmula: C₃₀H₂₄N₄O₈

Cor e Forma: White To Off-White Solid

Peso molecular: 568.54

Ref: 4Z-A-8455

Azilsartan Medoxomil

CAS: 863031-21-4

Azilsartan Medoxomil

Fórmula: C₃₀H₂₄N₄O₈

Pureza: 99.5%

Peso molecular: 568.53

Ref: 54-BUP12563

Azilsartan medoxomil

CAS: 863031-21-4

Fórmula: C₃₀H₂₄N₄O₈

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 568.53

Ref: 7W-GX5951

Azilsartan Medoxomil

Produto Controlado

CAS: 863031-21-4

Applications Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).
References Baker, W. & White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)

Fórmula: C₃₀H₂₄N₄O₈

Cor e Forma: Neat

Peso molecular: 568.53

Ref: TR-A926910

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

CAS: 863031-21-4

(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

Fórmula: C₃₀H₂₄N₄O₈

Pureza: 95%

Peso molecular: 568.53

Ref: IN-DG211032

Azilsartan Medoxomil

CAS: 863031-21-4

Azilsartan Medoxomil (TAK-491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults

Fórmula: C₃₀H₂₄N₄O₈

Pureza: 99.83%

Cor e Forma: Solid

Peso molecular: 568.53

Ref: TM-T6219

Azilsartan Medoxomil

CAS: 863031-21-4

Fórmula: C₃₀H₂₄N₄O₈

Peso molecular: 568.54

Ref: ST-EA-CP-A36033

Azilsartan Medoxomil

CAS: 863031-21-4

Fórmula: C₃₀H₂₄N₄O₈

Peso molecular: 568.5

Ref: BE-RMCA359059

Azilsartan Medoxomil-D5

Produto Controlado

CAS: 863031-21-4

Fórmula: C₃₀D₅H₁₉N₄O₈

Cor e Forma: Neat

Peso molecular: 573.564

Ref: TR-A926912

Azilsartan medoxomil

CAS: 863031-21-4

Azilsartan medoxomil is an antihypertensive drug, which is a prodrug of the angiotensin II receptor blocker azilsartan. It is synthesized through a chemical process involving the modification of the medoxomil ester, converting it into its active form upon absorption in the gastrointestinal tract. The primary mode of action of azilsartan medoxomil involves selective antagonism of the angiotensin II type 1 (AT1) receptor. By blocking the effects of angiotensin II—a potent vasoconstrictor—azilsartan medoxomil effectively reduces vascular resistance, leading to decreased blood pressure.

Fórmula: C₃₀H₂₄N₄O₈

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 568.53 g/mol

Ref: 3D-FD15814