CAS 874819-74-6

Fosfato de Toceranib

Descrição:

Fosfato de Toceranib é um fármaco de molécula pequena utilizado principalmente na medicina veterinária, particularmente para o tratamento de certos tipos de câncer em cães. É um inibidor da tirosina quinase que visa vias específicas envolvidas no crescimento tumoral e na angiogênese, tornando-o eficaz contra tumores que expressam o receptor do fator de crescimento endotelial vascular (VEGF). O composto é conhecido por sua capacidade de inibir a atividade de várias tirosina quinasas receptoras, que desempenham um papel crucial na sinalização celular relacionada ao crescimento e à proliferação. Fosfato de Toceranib é tipicamente administrado por via oral e é bem absorvido no trato gastrointestinal. Sua farmacocinética indica uma meia-vida moderada, permitindo a dosagem uma vez ao dia em ambientes clínicos. Os efeitos colaterais comuns podem incluir distúrbios gastrointestinais, letargia e alterações nas contagens de células sanguíneas, necessitando de monitoramento durante o tratamento. No geral, o fosfato de toceraib representa um avanço significativo no manejo de tumores caninos, proporcionando uma opção terapêutica direcionada que pode melhorar os resultados para os animais afetados.

Sinónimos:

• 5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide,phosphoric acid
• 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide phosphate

Toceranib phosphate

CAS: 874819-74-6

Fórmula: C₂₂H₂₈FN₄O₆P

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 494.4531

Ref: IN-DA00GU75

Toceranib Phosphate

CAS: 874819-74-6

Toceranib Phosphate

Pureza: ≥98%

Peso molecular: 494.46g/mol

Ref: 54-PC109154

Toceranib Phosphate

CAS: 874819-74-6

Toceranib Phosphate

Pureza: ≥98%

Peso molecular: 494.45g/mol

Ref: 54-BUP11203

Toceranib Phosphate

CAS: 874819-74-6

Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family.

Fórmula: C₂₂H₂₈FN₄O₆P

Pureza: 98.56%

Cor e Forma: Solid

Peso molecular: 494.45

Ref: TM-T7394

Toceranib Phosphate

Produto Controlado

CAS: 874819-74-6

Applications Toceranib Phosphate is a useful compound in the treatment of chemotherapy-induced diarrhea.
References Conte, L. A.: U.S. Pat. Appl. Publ. (2020), US 20200345687 A1

Fórmula: C₂₂H₂₅FN₄O₂·H₃PO₄

Cor e Forma: Neat

Peso molecular: 396.47 + (97.99)

Ref: TR-T525503

Toceranib phosphate - Bio-X ™

Produto Controlado

CAS: 874819-74-6

Toceranib phosphate is a receptor tyrosine kinase inhibitor. Toceranib phosphate has been shown to be effective in the treatment of skin cancer and other types of cancer, including lung cancer and breast cancer. It is approved in the US as a treatment for canine mastocytoma (mast cell tumours).

Fórmula: C₂₂H₂₅FN₄O₂·H₃O₄P

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 494.45 g/mol

Ref: 3D-BT162330

Toceranib phosphate

Produto Controlado

CAS: 874819-74-6

Toceranib phosphate is a tyrosine kinase inhibitor that is used to treat a variety of cancers. It has been shown to be an effective treatment for solid tumours, such as lung cancer and renal cell carcinoma. Toceranib has also been shown to have anti-angiogenic properties, which may contribute to its antitumor response. One study found that the drug is cleared by the liver and eliminated by the kidneys, with a half-life of approximately 15 hours. A phase II clinical trial found that Toceranib was well tolerated in patients with metastatic breast cancer who had previously been treated with anthracyclines and taxanes. The most common adverse effects were diarrhea (in 8% of subjects), hypertension (6%), and nausea (3%).

Fórmula: C₂₂H₂₅FN₄O₂•H₃O₄P

Pureza: 90%

Cor e Forma: Powder

Peso molecular: 494.45 g/mol

Ref: 3D-FT104292