CAS 876755-27-0

(αS,4R)-4-[4-(2-Hidroxietoxi)fenil]-2,5-dioxo-N-[4-(1-oxopropil)-2-tiazolil]-α-[(1S)-1-feniletil]-1-imidazolidinaacetamida

Fórmula: C₂₇H₂₈N₄O₆S

InChI: InChI=1S/C27H28N4O6S/c1-3-21(33)20-15-38-26(28-20)30-24(34)23(16(2)17-7-5-4-6-8-17)31-25(35)22(29-27(31)36)18-9-11-19(12-10-18)37-14-13-32/h4-12,15-16,22-23,32H,3,13-14H2,1-2H3,(H,29,36)(H,28,30,34)/t16-,22+,23-/m0/s1

Chave InChI: InChIKey=RKKBPPTYPGTSEA-FNVCAUGXSA-N

SMILES: [C@H]([C@@H](C)C1=CC=CC=C1)(C(NC2=NC(C(CC)=O)=CS2)=O)N3C(=O)[C@H](NC3=O)C4=CC=C(OCCO)C=C4

Sinónimos:

• RO 4927350
• 1-Imidazolidineacetamide, 4-[4-(2-hydroxyethoxy)phenyl]-2,5-dioxo-N-[4-(1-oxopropyl)-2-thiazolyl]-α-[(1S)-1-phenylethyl]-, (αS,4R)-
• (αS,4R)-4-[4-(2-Hydroxyethoxy)phenyl]-2,5-dioxo-N-[4-(1-oxopropyl)-2-thiazolyl]-α-[(1S)-1-phenylethyl]-1-imidazolidineacetamide
• Ro 4927350
• (2S,3S)-2-[(4R)-4-[4-(2-Hydroxyethoxy)phenyl]-2,5-dioxoimidazolidin-1-yl]-3-phenyl-N-(4-propionylthiazol-2-yl)butanamide

RO4927350

CAS: 876755-27-0

RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.

Fórmula: C₂₇H₂₈N₄O₆S

Cor e Forma: Solid

Peso molecular: 536.6

Ref: TM-T68459

(2S,3S)-2-((R)-4-(4-(2-Hydroxyethoxy)phenyl)-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-N-(4-propionylthiazol-2-yl)butyramide

CAS: 876755-27-0

(2S,3S)-2-((R)-4-(4-(2-Hydroxyethoxy)phenyl)-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-N-(4-propionylthiazol-2-yl)butyramide is an aromatic ketone that has been shown to inhibit mitogen activated protein kinase (MAPK) and mitogen activated protein kinases (MAPKs). It is a potent inhibitor of the MAPK signaling pathway. This drug binds to the ATP binding site on MAPK and blocks the exchange of ATP for MgATP, which prevents the phosphorylation of tyrosine residues on MAPK. The carboxy group in this compound reacts with the primary amino group on MAPK to form a condensation product. This reaction inhibits protein synthesis by blocking the activation of ribosomes by tRNA.

Fórmula: C₂₇H₂₈N₄O₆S

Pureza: Min. 95%

Peso molecular: 536.6 g/mol

Ref: 3D-BKB75527