CAS 92999-29-6

(S)-9-[3-Hidroxi-2-(fosfonometoxi)propil]adenina

Descrição:

(S)-9-[3-Hidroxi-2-(fosfonometoxi)propil]adenina, comumente referido como um análogo de nucleotídeo, é caracterizado por sua semelhança estrutural com a adenina, um componente fundamental dos ácidos nucleicos. Este composto apresenta um grupo fosfonometóxi, que contribui ao seu potencial como agente antiviral, particularmente contra infecções virais como o HIV. A presença do grupo hidroxila aumenta sua solubilidade e reatividade, tornando-o um assunto de interesse na química medicinal. Sua estereoquímica, indicada pela configuração (S), desempenha um papel crucial em sua atividade biológica e interação com enzimas. O mecanismo de ação do composto geralmente envolve a inibição da replicação viral ao interferir na síntese de ácidos nucleicos. Além disso, sua estabilidade e biodisponibilidade são fatores importantes que influenciam sua eficácia terapêutica. No geral, (S)-9-[3-Hidroxi-2-(fosfonometoxi)propil]adenina representa uma área significativa de pesquisa no desenvolvimento de terapias antivirais e destaca a importância das modificações estruturais na melhoria das propriedades farmacológicas dos análogos de nucleosídeos.

Fórmula: C₉H₁₄N₅O₅P

InChI: InChI=1/C9H14N5O5P/c10-8-7-9(12-3-11-8)14(4-13-7)1-6(2-15)19-5-20(16,17)18/h3-4,6,15H,1-2,5H2,(H2,10,11,12)(H2,16,17,18)/t6-/m0/s1

Chave InChI: InChIKey=FRPXSOOHWNMLPH-LURJTMIESA-N

SMILES: C([C@H](OCP(=O)(O)O)CO)N1C=2C(N=C1)=C(N)N=CN2

Sinónimos:

• (S)-(1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yloxy)methylphosphonic acid
• (S)-9-(3-Hydroxy-2-(phosphonomethoxy)propyl]adenine
• (S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine
• ({[(2S)-1-(6-amino-9H-purin-9-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
• 9-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]adenine
• Gs 0577
• Hpmpa
• Hpmpa-(S)
• P-[[(1S)-2-(6-Amino-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• Phosphonic acid, P-[[(1S)-2-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl]-
• Phosphonic acid, [[(1S)-2-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl]-
• Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl]-, (S)-
• 9-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]-9H-purine-6-amine
• (S)-HPMPA
• [[(1S)-1-(Hydroxymethyl)-2-(6-amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid
• [[(S)-2-(6-Amino-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• (S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid

(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid

CAS: 92999-29-6

(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid

Fórmula: C₉H₁₄N₅O₅P

Pureza: 95%

Peso molecular: 303.22

Ref: 54-OR1064089

(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid

CAS: 92999-29-6

Fórmula: C₉H₁₄N₅O₅P

Pureza: %

Peso molecular: 303.2117

Ref: IN-DA00H1LF

(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid

CAS: 92999-29-6

(S)-(((1-(6-Amino-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid

Fórmula: C₉H₁₄N₅O₅P

Pureza: 95+%

Peso molecular: 303.21

Ref: IN-DG305159

(S)-HPMPA

CAS: 92999-29-6

(S)-HPMPA is a nucleotide analogue, which is a chemically synthesized compound designed to mimic nucleotides. It acts as both an antiviral and an antitumor agent, sourced primarily through synthetic chemistry involving the modification of naturally occurring nucleotide structures. The mode of action of (S)-HPMPA involves mimicking natural substrates of various viral polymerases and cellular enzymes, thereby inhibiting viral DNA synthesis and disrupting the replication cycle of DNA viruses. Additionally, it can interfere with certain cellular pathways contributing to its antitumor effects.

Fórmula: C₉H₁₄N₅O₅P

Pureza: Min. 95%

Peso molecular: 303.21 g/mol

Ref: 3D-NH137606