CAS 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC

Descrição:

Suc-Leu-Leu-Val-Tyr-AMC, também conhecido como um substrato peptídico, é um composto sintético que consiste em uma sequência de aminoácidos: leucina succinilada, leucina, valina, tirosina e 7-amido-4-metilcumarina (AMC). Este composto é utilizado principalmente em ensaios bioquímicos para estudar enzimas proteolíticas, particularmente aquelas que quebram ligações peptídicas. O grupo succinilo melhora a solubilidade e estabilidade do peptídeo, enquanto a parte AMC serve como um repórter fluorescente, permitindo a detecção da atividade enzimática por meio de medições de fluorescência. As características desta substância incluem sua capacidade de sofrer hidrólise por proteases específicas, resultando na liberação de AMC, que pode ser medida quantitativamente. Essa propriedade a torna valiosa em aplicações de pesquisa, particularmente nos campos de enzimiologia e descoberta de fármacos. Além disso, a estrutura de Suc-Leu-Leu-Val-Tyr-AMC contribui para sua especificidade para certas enzimas, tornando-a uma ferramenta útil para estudar cinética enzimática e inibição.

Fórmula: C₄₀H₅₃N₅O₁₀

InChI: InChI=1/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)/t29?,30?,31-,36-/m0/s1

Chave InChI: UVFAEQZFLBGVRM-MSMWPWNWSA-N

SMILES: CC(C)CC(C(=NC(CC(C)C)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1ccc(cc1)O)C(=Nc1ccc2c(C)cc(=O)oc2c1)O)O)O)O)N=C(CCC(=O)O)O

Sinónimos:

• N-succinyl-leu-leu-val-tyr 7-amido-4-*methylcouma
• Succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide
• Llvy-mca
• N-Succinyl-leu-leu-val-tyr-7-amido-4-methylcoumarin
• Sllvt-mca
• Suc-leu-leu-val-tyr-7-amino-4-methylcoumarin
• Suc-leu-leu-val-tyr-mca
• Suc-llvy-mca
• L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• N-(3-carboxypropanoyl)leucylleucyl-L-valyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-tyrosinamide

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

The fluorogenic substrate Suc-LLVY-AMC is used for measuring the chymotrypsin-like activity of the 20S proteasome, in combination with e.g. Bz-VGR-AMC (for assaying its trypsin-like activity) and Z-LLE-AMC (for determining its PGPH activity). Suc-LLVY-AMC is also cleaved by a chymotrypsin-like enzyme from sperm extract of the ascidian Halocynthia roretzi, a strong inhibitor of fertilization. The substrate has also been used to analyze the chymotrypsin-like activity of trypsins as well as chymase from rat mast cells. Furthermore, Suc-LLVY-AMC is a substrate for carboxypeptidase Y, proteinase yscE (kexin), ingensin, as well as for porcine calpain isozymes I and II and for papain.

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: > 98%

Cor e Forma: White

Peso molecular: 763.89

Ref: 01-4011369

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: 95% (TFA salt)

Peso molecular: 763.88

Ref: 54-OR1125759

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic tetrapeptide substrate for 20S proteasome and chymotrypsin-like proteases, used in drug screening.

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 763.8763

Ref: TM-TP1308

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 763.8763

Ref: IN-DA01E5Y8

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin

CAS: 94367-21-2

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: ≥ 95.0%

Cor e Forma: White to off-white powder

Peso molecular: 763.89

Ref: 7W-GL1880

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a peptide that is an activator of ion channels. It can be used to study the effects of ion channel activation on various cells and tissues. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to inhibit ligand binding to some receptors, such as the acetylcholine receptor. This peptide can also be used as a research tool for pharmacology, protein interactions, and antibody production.

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: Min. 95%

Peso molecular: 763.88 g/mol

Ref: 3D-MLL-3120-V

Suc-Leu-Leu-Val-Tyr-AMC

CAS: 94367-21-2

Suc-Leu-Leu-Val-Tyr-AMC is a cyclin D2 inhibitor that binds to the proteasome and inhibits its function. It has been shown to be useful for the treatment of cancerous tissues as it inhibits the production of prostaglandin J2, which is involved in the progression of cancer cells. Suc-Leu-Leu-Val-Tyr-AMC has also been shown to have antioxidant properties and can inhibit oxidative injury. This drug may be used to prevent or treat various diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, diabetes mellitus type II, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and septic shock.

Fórmula: C₄₀H₅₃N₅O₁₀

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 763.88 g/mol

Ref: 3D-FS110535