CAS 957135-43-2

Fórmula: C62H84N14O6

InChI: InChI=1S/C62H84N14O6/c1-41(63-3)57(77)65-49-27-13-11-25-47-33-35-53(75(47)61(49)81)59(79)67-55(45-21-7-5-8-22-45)51-39-73(71-69-51)37-17-15-19-43-29-31-44(32-30-43)20-16-18-38-74-40-52(70-72-74)56(46-23-9-6-10-24-46)68-60(80)54-36-34-48-26-12-14-28-50(62(82)76(48)54)66-58(78)42(2)64-4/h5-10,21-24,29-32,39-42,47-50,53-56,63-64H,11-20,25-28,33-38H2,1-4H3,(H,65,77)(H,66,78)(H,67,79)(H,68,80)/t41-,42-,47-,48-,49-,50-,53-,54-,55-,56-/m0/s1

Chave InChI: LGYDZXNSSLRFJS-IOQQVAQYSA-N

SMILES: C[C@@H](C(=O)N[C@H]1CCCC[C@H]2CC[C@H](N2C1=O)C(=O)N[C@@H](C3=CC=CC=C3)C4=CN(N=N4)CCCCC5=CC=C(C=C5)CCCCN6C=C(N=N6)[C@H](C7=CC=CC=C7)NC(=O)[C@@H]8CC[C@H]9N8C(=O)[C@H](CCCC9)NC(=O)[C@H](C)NC)NC

SM-164

CAS: 957135-43-2

SM-164

Fórmula: C₆₂H₈₄N₁₄O₆

Pureza: 98.5%

Peso molecular: 1121.42

Ref: 54-BUP02016

(3S,3'S,6S,6'S,10aS,10a'S)-N,N'-((1S,1'S)-((1,4-Phenylenebis(butane-4,1-diyl))bis(1H-1,2,3-triazole-1,4-diyl))bis(phenylmethylene))bis(6-((S)-2-(methylamino)propanamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide)

CAS: 957135-43-2

Fórmula: C₆₂H₈₄N₁₄O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1121.4206

Ref: IN-DA01EEG7

SM-164

CAS: 957135-43-2

SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.

Fórmula: C₆₂H₈₄N₁₄O₆

Pureza: 96.8% - 99.92%

Cor e Forma: Solid

Peso molecular: 1121.4207

Ref: TM-T12932L

SM-164

CAS: 957135-43-2

(3S,3'S,6S,6'S,10aS,10a'S)-N,N'-((1S,1'S)-((1,4-Phenylenebis(butane-4,1-diyl))bis(1H-1,2,3-triazole-1,4-diyl))bis(phenylmethylene))bis(6-((S)-2-(methylamino)propanamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide)

Fórmula: C₆₂H₈₄N₁₄O₆

Pureza: 98%

Peso molecular: 1121.42

Ref: IN-DG631068

SM-164

CAS: 957135-43-2

SM-164 is a monoclonal antibody that targets the protein TNF-related apoptosis-inducing ligand (TRAIL), which is involved in the death of cancer cells. TRAIL induces apoptosis by binding to the TRAIL receptor 1 (TRAILR1) and activating caspase-8, -9, and -10. SM-164 has minimal toxicity and enhances the radiosensitizing effect of adriamycin. It also inhibits caspase activity by antagonizing TRAIL signaling. Structural analysis revealed that SM-164 binds to TRAIL with an affinity of 0.7 nM, resulting in inhibition of proteolytic cleavage and preventing activation of caspases. This inhibited proteolysis prevents degradation of cellular proteins, leading to cell death by apoptosis.

Fórmula: C₆₂H₈₄N₁₄O₆

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,121.42 g/mol

Ref: 3D-FS137718