CAS 968-81-0

Acetohexamida

Descrição:

Acetohexamida é um composto químico classificado como uma sulfonilureia, utilizado principalmente no manejo do diabetes mellitus tipo 2. Funciona como um agente hipoglicemiante oral, estimulando a liberação de insulina do pâncreas e aumentando a sensibilidade à insulina nos tecidos periféricos. A estrutura molecular de Acetohexamida inclui uma cadeia de hexametileno e um grupo acetamida, contribuindo para suas propriedades farmacológicas. É tipicamente administrado em forma de comprimidos e é conhecido por sua eficácia moderada na redução dos níveis de glicose no sangue. Acetohexamida tem uma solubilidade relativamente baixa em água, o que pode afetar sua absorção e biodisponibilidade. Efeitos colaterais comuns podem incluir distúrbios gastrointestinais, hipoglicemia e reações alérgicas. Assim como outras sulfonilureias, seu uso requer monitoramento cuidadoso dos níveis de glicose no sangue para evitar complicações potenciais. O composto é metabolizado no fígado, e sua farmacocinética pode ser influenciada por fatores como idade, função hepática e medicamentos concomitantes. No geral, Acetohexamida desempenha um papel no manejo do diabetes, embora tenha sido em grande parte substituído por agentes mais novos com perfis de segurança e eficácia aprimorados.

Fórmula: C₁₅H₂₀N₂O₄S

InChI: InChI=1/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

Chave InChI: InChIKey=VGZSUPCWNCWDAN-UHFFFAOYSA-N

SMILES: S(NC(NC1CCCCC1)=O)(=O)(=O)C2=CC=C(C(C)=O)C=C2

Sinónimos:

• 1-(4-Acetylbenzenesulfonyl)-3-Cyclohexylurea
• 1-(4-Acetylphenyl)sulfonyl-3-cyclohexylurea
• 1-(p-Acetylbenzenesulfonyl)-3-cyclohexylurea
• 1-[(p-Acetylphenyl)sulfonyl]-3-cyclohexylurea
• 4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide
• 4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide
• Acetohexamid
• Acetohexamida
• Benzenesulfonamide, 4-acetyl-N-[(cyclohexylamino)carbonyl]-
• Dimelin
• Dimelin (antidiabetic)
• Dimelor
• Dymelor
• Gamadiabet
• Hypoglicil
• Metaglucina
• Minoral
• N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea
• Ordimel
• Tsiklamid
• U 14812
• Urea, 1-[(p-acetylphenyl)sulfonyl]-3-cyclohexyl-
• Acetohexamide
• DyMelor-d6
• -d6 DiMelin-d6
• Hypoglicil-d6
• 4-Acetyl-N-[(cyclohexyl-d6-aMino)carbonyl]benzenesulfonaMide
• Acetohexamide (250 mg)
• AcetohexaMide-d6
• Cyclamide
• 1-(4-acetylphenyl)sulfonyl-3-cyclohexyl-urea
• 1-cyclohexyl-3-(4-ethanoylphenyl)sulfonyl-urea
• gamadiaber
• 1-[(p-Acetylphenyl)su
• 1-((p-acetylphenyl)sulfonyl)-3-cyclohexyl-ure
• GaMadiabet-d6
• 4-acetyl-n-[(cyclohexylamino)carbonyl]-benzenesulfonamid
• nci-c03247
• U 14812-d6
• 4-acetyl-n-benzenesulfonamide
• 1-(p-acetylbenzenesulfonyl)-3-cyclohexylure
• 1-(p-Acetylbenzenesulfonyl)
• OrdiMel-d6
• 4-acetyl-n-((cyclohexylamino)carbonyl)-benzenesulfonamid
• ACETOHEXAMIDE, USP GRADE ORAL HYPOGLYCEM IC AGE
• Metaglucina-d6
• u14812
• TsiklaMid-d6
• Minoral-d6

Acetohexamide

CAS: 968-81-0

Acetohexamide

Fórmula: C₁₅H₂₀N₂O₄S

Pureza: ≥98%

Peso molecular: 324.4

Ref: 54-BUP14643

Acetohexamide

CAS: 968-81-0

Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity.

Fórmula: C₁₅H₂₀N₂O₄S

Pureza: 99.01% - 99.19%

Cor e Forma: White Solid

Peso molecular: 324.395

Ref: TM-T0816

Acetohexamide

CAS: 968-81-0

Fórmula: C₁₅H₂₀N₂O₄S

Peso molecular: 324.40

Ref: 7W-GL0522

4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide

CAS: 968-81-0

Fórmula: C₁₅H₂₀N₂O₄S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 324.3953

Ref: IN-DA005SIZ

Acetohexamide (Standard)

CAS: 968-81-0

Acetohexamide (Standard) is the standard substance of Acetohexamide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.

Fórmula: C₁₅H₂₀N₂O₄S

Peso molecular: 324.395

Ref: TM-TMSM-0357

Acetohexamide

CAS: 968-81-0

Fórmula: C₁₅H₂₀N₂O₄S

Cor e Forma: White To Light Red

Peso molecular: 324.4

Ref: 61-FOR1726.00

Acetohexamide

Produto Controlado

CAS: 968-81-0

Applications Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.
References Yu, T-F. et al.: Metab. Clin. Exp., 17, 309 (1968); Harrower, A.D.B. et al.: Clin. Pharmacokin., 31, 111 (1996); Hirota, Y. et al.: Diab. Med., 26, 948 (2009);

Fórmula: C₁₅H₂₀N₂O₄S

Cor e Forma: Neat

Peso molecular: 324.4

Ref: TR-A162650

Acetohexamide

CAS: 968-81-0

Fórmula: C₁₅H₂₀N₂O₄S

Cor e Forma: Solid

Peso molecular: 324.4

Ref: BE-BePure-20056

Acetohexamide

CAS: 968-81-0

Acetohexamide

Fórmula: C₁₅H₂₀N₂O₄S

Pureza: 99%

Peso molecular: 324.4

Ref: IN-DG16071

Acetohexamide

CAS: 968-81-0

Pureza: 98%

Peso molecular: 324.4

Ref: 10-F980328

Acetohexamide

CAS: 968-81-0

Acetohexamide is a hypoglycemic drug that binds to the sulfonylurea receptor on pancreatic beta-cells and stimulates insulin release. It has been shown to have an oral hypoglycemic effect in humans, as well as in rats. Acetohexamide has been shown to inhibit the action of nonsteroidal anti-inflammatory drugs, such as indomethacin, through competitive inhibition. Acetohexamide also inhibits the enzyme activity of estradiol benzoate and acetohexamide hydrolase. This drug is not active against bacteria or fungi, but has been shown to be effective against some viruses. Acetohexamide is absorbed by the gastrointestinal tract and excreted unchanged in urine and feces. The drug does not bind to proteins and does not cross the blood-brain barrier.

Fórmula: C₁₅H₂₀N₂O₄S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 324.4 g/mol

Ref: 3D-FA16951