CAS 992-21-2

Limeciclina

Descrição:

Limeciclina é um antibiótico semissintético pertencente à classe das tetraciclinas, utilizado principalmente para tratar várias infecções bacterianas. Apresenta uma atividade antibacteriana de amplo espectro contra bactérias Gram-positivas e Gram-negativas, inibindo a síntese de proteínas por meio da ligação à subunidade ribossômica 30S. Essa ação impede o crescimento e a reprodução das bactérias. Limeciclina é caracterizado por sua estabilidade em ambientes ácidos, o que aumenta sua biodisponibilidade quando administrado por via oral. É frequentemente prescrito para condições como acne, infecções do trato respiratório e certas infecções cutâneas. O composto é geralmente bem tolerado, embora possa causar efeitos colaterais como distúrbios gastrointestinais, fotossensibilidade e efeitos potenciais no desenvolvimento de ossos e dentes em crianças. Assim como outras tetraciclinas, é contraindicado em mulheres grávidas e crianças pequenas devido ao risco de descoloração dos dentes e efeitos esqueléticos.

Fórmula:C₂₉H₃₈N₄O₁₀

InChI:InChI=1/C29H38N4O10/c1-28(42)13-7-6-9-17(34)18(13)22(35)19-14(28)11-15-21(33(2)3)23(36)20(25(38)29(15,43)24(19)37)26(39)32-12-31-16(27(40)41)8-4-5-10-30/h6-7,9,14-16,21,31-32,34-35,39,42-43H,4-5,8,10-12,30H2,1-3H3,(H,40,41)/b26-20+/t14?,15-,16?,21-,28+,29-/m0/s1

Chave InChI:InChIKey=AHEVKYYGXVEWNO-UEPZRUIBSA-N

SMILES:O[C@@]12[C@@](C[C@]3(C(=C1O)C(=O)C=4C([C@@]3(C)O)=CC=CC4O)[H])([C@H](N(C)C)C(O)=C(C(NCNCCCC[C@@H](C(O)=O)N)=O)C2=O)[H]

Sinónimos:

(+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, lysinemethylene deriv.
L-Lysine, N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-
L-Lysine, N6-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-, [4S-(4α,4aα,5aα,6β,12aα)]-
Armyl
Ciclisin
Ciclolysal
Ciclolysine
Infaciclina
L-Lysine, N6-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-, [4S-(4α,4aα,5aα,6β,12aα)]-
Limeciclina
Lisinbiotic
Lisinciclina
Lymecyclin
Lymecycline
Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-
Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-, L-
Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-
Lysine, N6-[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]-, L-
Mucomycin
N-Lysinomethyltetracycline
N2-[[(+)-5-Amino-5-carboxypentylamino]methyl]tetracycline
N6-[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]lysine
N6-[[[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-oxtahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
N2-[[(+)-5-Amino-5-carboxypentylamino]methyl]tetracycline
N6-[[4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido]methyl]lysine
N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
Tertamyl
Tetracycline-L-methylenelysine
Tetracycline-L-methylenelysine
Tetracyclinemethylenelysine
Tetralisal
Tetralysal
Tetramyl
Vebicyclysal
L-Lysine, N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-
N~2~-({[(Z)-[(4aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracen-2(1H)-ylidene](hydroxy)methyl]amino}methyl)lysine
(2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
N~2~-({[(E)-[(4S,4aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-3,4,4a,5,5a,6,12,12a-octahydrotetracen-2(1H)-ylidene](hydroxy)methyl]amino}methyl)lysine
N-(N2-lysinomethyl)tetracycline
N6-[[[[(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-L-lysine
lymecycline USP/EP/BP
Lymecycline (85%)
N6-[[(4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,6α,10,12,12aβ-pentahydroxy-6-methyl-1,11-dioxonaphthacen-2-yl]carbonylaminomethyl]-L-lysine
Tetracyclinemethylene lysine
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Foram encontrados 10 produtos.

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Lymecycline
CAS:
- 992-21-2
Lymecycline
Fórmula:C₂₂H₂₃ClN₂O₈
Cor e Forma:Dark Yellow
Peso molecular:478.8796
Ref: 47-218
100mg
211,00€
IVA não incluído
+ Info
(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid
CAS:
- 992-21-2
(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid
Fórmula:C₂₉H₃₈N₄O₁₀
Pureza:95%
Peso molecular:602.63
Ref: 54-OR1120108
5mg
402,00€
IVA não incluído
10mg
586,00€
IVA não incluído
25mg
801,00€
IVA não incluído
50mg
1.141,00€
IVA não incluído
+ Info
(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid
CAS:
- 992-21-2
Fórmula:C₂₉H₃₈N₄O₁₀
Pureza:95%
Cor e Forma:Solid
Peso molecular:602.6328
Ref: IN-DA01CC6C
25mg
592,00€
IVA não incluído
50mg
949,00€
IVA não incluído
+ Info
Lymecycline
CAS:
- 992-21-2
Lymecycline (Mucomycin) is a tetracycline-class antibacterial agent that inhibits bacterial 30S ribosomal protein synthesis, exhibits pH-dependent release in an α-Fe₂O₃ nanocarrier drug delivery system, and can also serve as a template and signal conjugate for molecularly imprinted assays.
Fórmula:C₂₉H₃₈N₄O₁₀
Cor e Forma:Solid
Peso molecular:602.64
Ref: TM-T20164
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Lymecycline-d8 (>80%)
Produto ControladoTenha em atenção que se trata de um produto controlado em alguns países e que tem de ser tratado em conformidade com os regulamentos relevantes. Esteja ciente de que isto pode implicar despesas e documentação adicionais.
CAS:
- 992-21-2
Stability Light Sensitive, Temperature Sensitive
Applications Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),
Fórmula:C₂₉H₃₀D₈N₄O₁₀
Pureza:>80%
Cor e Forma:Neat
Peso molecular:610.68
Ref: TR-L487802
1mg
645,00€
IVA não incluído
+ Info
Lymecycline
CAS:
- 992-21-2
Fórmula:C₂₉H₃₈N₄O₁₀
Peso molecular:602.64
Ref: 4Z-L-237001
5mg
A consultar
10mg
A consultar
25mg
A consultar
50mg
A consultar
100mg
A consultar
+ Info
Lymecycline
CAS:
- 992-21-2
Lymecycline is a tetracycline antibiotic that has been shown to be effective in the treatment of inflammatory bowel disease, chronic arthritis, and experimental models of inflammatory reactions. Lymecycline inhibits epidermal growth factor (EGF) and its receptor EGF-R. This inhibition leads to reduced inflammation in the bowel. Lymecycline also has an anti-inflammatory effect on the skin, inhibiting reactive oxygen species (ROS) production from neutrophils and macrophages. It also reduces the symptoms of toxic epidermal necrolysis by preventing ROS production and reducing cytokines such as TNF-α and IL-1β. Lymecycline binds to magnesium ions, which are necessary for bacterial growth and replication. This binding leads to bacteriostatic activity against bacteria that are sensitive to lymecycline, including Mycobacterium tuberculosis and other infectious diseases. The histological
Fórmula:C₂₉H₃₈N₄O₁₀
Pureza:Min. 85 Area-%
Cor e Forma:Powder
Peso molecular:602.63 g/mol
Ref: 3D-FL164019
5mg
267,00€
IVA não incluído
10mg
376,00€
IVA não incluído
25mg
557,00€
IVA não incluído
+ Info
Lymecycline
CAS:
- 992-21-2
Fórmula:C₂₉H₃₈N₄O₁₀
Peso molecular:602.6
Ref: BE-RMCT114019
25mg
2.181,00€
IVA não incluído
+ Info
Lymecycline (85%)
CAS:
- 992-21-2
Stability Temperature sensitive
Applications A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial.
References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),
Fórmula:C₂₉H₃₈N₄O₁₀
Pureza:85%
Cor e Forma:Neat
Peso molecular:602.63
Ref: TR-L487800
5mg
209,00€
IVA não incluído
10mg
306,00€
IVA não incluído
100mg
823,00€
IVA não incluído
+ Info
Lymecycline
CAS:
- 992-21-2
Fórmula:C₂₉H₃₈N₄O₁₀
Peso molecular:602.64
Ref: ST-EA-CP-L64000
10mg
A consultar
25mg
A consultar
50mg
A consultar
100mg
A consultar

CAS 992-21-2

Limeciclina

Lymecycline

Ref: 47-218

(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid

Ref: 54-OR1120108

(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid

Ref: IN-DA01CC6C

Lymecycline

Ref: TM-T20164

Lymecycline-d8 (>80%)

Ref: TR-L487802

Lymecycline

Ref: 4Z-L-237001

Lymecycline

Ref: 3D-FL164019

Lymecycline

Ref: BE-RMCT114019

Lymecycline (85%)

Ref: TR-L487800

Lymecycline

Ref: ST-EA-CP-L64000