CAS 99614-01-4

Cloridrato de ondansetrona

Descrição:

Cloridrato de ondansetrona é um antagonista seletivo do receptor de serotonina 5-HT3, utilizado principalmente como antiemético para prevenir náuseas e vômitos causados por quimioterapia, radioterapia e cirurgia. É um pó cristalino branco a off-white que é solúvel em água e possui uma fórmula molecular que reflete sua estrutura complexa. A substância apresenta alta afinidade pelos receptores 5-HT3, bloqueando a ação da serotonina, que é responsável por desencadear náuseas e vômitos. Cloridrato de ondansetrona é tipicamente administrado por via oral ou intravenosa, e sua farmacocinética inclui rápida absorção e uma meia-vida relativamente curta, necessitando de múltiplas doses em alguns regimes de tratamento. O composto é geralmente bem tolerado, com efeitos colaterais comuns que incluem dor de cabeça, constipação e tontura. É importante notar que, embora eficaz, o ondansetron deve ser usado com cautela em pacientes com certas condições médicas, e seu uso durante a gravidez deve ser avaliado cuidadosamente. No geral, Cloridrato de ondansetrona é um medicamento crítico no manejo de náuseas e vômitos induzidos por quimioterapia, contribuindo significativamente para o conforto do paciente e a qualidade de vida durante o tratamento do câncer.

Fórmula: C₁₈H₁₉N₃O·ClH

InChI: InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H

Chave InChI: InChIKey=MKBLHFILKIKSQM-UHFFFAOYSA-N

SMILES: O=C1C=2C=3C(N(C)C2CCC1CN4C(C)=NC=C4)=CC=CC3.Cl

Sinónimos:

• (+-)-2,3-Dihydro-9-Methyl-3-((2-Methylimidazol-1-Yl)Methyl)Carbazol-4(1H)-One Monohydrochloride Dihydrate
• 1,2,3,4-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-9H-carbazol-4-one hydrochloride
• 1,2,3,9-Tetrahydro-9-Methyl-3-[(2-Methyl-1H-Imidazol-1-Yl)Methyl]-4H-Carbazol-4-One Hydrochloride Dihydrate
• 1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride (1:1)
• 4H-Carbazol-4-One, 1,2,3,9-Tetrahydro-9-Methyl-3-((2-Methyl-1H-Imidazol-1-Yl)Methyl)-, Monohydrochloride, (+-)-, Dihydrate
• 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-, monohydrochloride
• 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, hydrochloride (1:1)
• 9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one monohydrochloride
• 9-Methyl-3-[(2-Methylimidazol-1-Yl)Methyl]-2,3-Dihydro-1H-Carbazol-4-One Dihydrate Hydrochloride
• 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride (1:1)
• 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dihydrate
• Carbazol-4-One Dihydrate
• Emeset
• Gr 38032F
• NSC 665799
• Odansetron Hydrochloride Dihydrate
• Ondansetron HCl
• Ondansetron Hcl Dihydrate
• Ondansetron Hydrochloride Hydrate
• Ondansetron hydrochloride
• Osetron
• Sn 307
• Zofran
• Zofran ODT
• Zophren

Ondansetron Hydrochloride Dihydrate

CAS: 103639-04-9, 99614-01-4, 99614-02-5

Fórmula: C₁₈H₁₉N₃O·HCl·2H₂O

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 365.86

Ref: 3B-O0407

Ondansetron hydrochloride

CAS: 99614-01-4

Ondansetron hydrochloride

Fórmula: C₁₈H₁₉N₃O·HCl

Pureza: ≥98%

Peso molecular: 329.82

Ref: 54-BUP11722

Ondansetron HCl

CAS: 99614-01-4

Fórmula: C₁₈H₁₉N₃O·HCl

Cor e Forma: White To Off-White Solid

Peso molecular: 293.37 36.46

Ref: 4Z-O-037

Ondansetron hydrochloride

CAS: 99614-01-4

Ondansetron hydrochloride (Zofran) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation

Fórmula: C₁₈H₁₉N₃O·HCl

Pureza: 99.78%

Cor e Forma: Solid

Peso molecular: 329.82

Ref: TM-T6616

Ondansetron HCl

CAS: 99614-01-4

9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride

Fórmula: C₁₈H₂₀ClN₃O

Pureza: 99%

Peso molecular: 329.82

Ref: IN-DG41117

Ondansetron HCl

CAS: 99614-01-4

Serotonin receptor 5-HT3 antagonist

Fórmula: C₁₈H₂₀N₃OCl

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 329.82 g/mol

Ref: 3D-FO65112

Ondansetron hydrochloride - Bio-X ™

CAS: 99614-01-4

Ondansetron is a serotonin 5-HT3 receptor antagonist that has been shown to inhibit the effects of serotonin in the gastrointestinal tract, thereby preventing nausea and vomiting that is caused by cancer chemotherapy. Chemotherapy and radiotherapy are associated with the release of serotonin (5-HT) from enterochromaffin cells of the small intestine, initiating a vomiting reflex through stimulation of 5-HT3 receptors located on vagal afferents. Ondansetron blocks the initiation of this reflex. The drug binds to receptors on cells in the gastrointestinal tract that are normally activated by serotonin, thereby blocking its effect.

Fórmula: C₁₈H₂₀N₃OCl

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 329.82 g/mol

Ref: 3D-BO164177